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Guidelines for the programmatic management of drug-resistant
Guidelines for the programmatic management of drug-resistant

... The first two editions of the guidelines were published by WHO in 2006 and 2008 through writing committees of international experts. The current 2011 update was undertaken in accordance with the requirements of the Handbook for Guideline Development (2010) of WHO’s Guidelines Review Committee. The p ...
2008 Outcomes Report - Minnesota Gastroenterology
2008 Outcomes Report - Minnesota Gastroenterology

... and an important investment in the future of our patients. Eligible MNGI patients have opportunities to participate in national and international clinical research studies. Our patients are some of the first to receive new therapies and treatments, such as blue light treatment of the stomach for era ...
Clinical guide for primary health care physicians
Clinical guide for primary health care physicians

... and liver function tests. 3. Radiological evaluation: Is not always needed, yet sometimes maybe of prime importance: • Plain X-rays: of the chest (whenever chest infection is suspected) and abdomen (in which pneumoperitonium, gas-fluid levels, fecaliths, gallstones, urinary stones, ascitis and oblit ...
Read the white paper
Read the white paper

... Canadians impacted by rare disorders with no current therapies for their condition. Significant scientific progress has been made in Canada and abroad. Research and development, commercialization and patient access related to DRDs is, however, more challenging than conventional therapies and medicin ...
Leukemia - MD Anderson Cancer Center
Leukemia - MD Anderson Cancer Center

... and targeted agents, it does not target specific tumor cells, which vary dramatically from patient to patient. All patients have T-cells with targetable checkpoints, implying that immunotherapy approaches may work universally. Therefore, it is not surprising that recent in vitro and clinical studies ...
Neuro Update Newsletter v12n3 2015 - MC5520-0715
Neuro Update Newsletter v12n3 2015 - MC5520-0715

... Researchers at Mayo Clinic are making significant advances in understanding the natural history and pathophysiology of MS, laying the groundwork for potential treatments. The goal is to slow or prevent the progressive phase of MS. “The management of progressive MS remains frustrating, and progress i ...
Myozyme : EPAR - Scientific Discussion
Myozyme : EPAR - Scientific Discussion

... features with that of infantile and late-onset Pompe patients; however, if the life span of mice was considered, the model resembled more closely a late in life disease progression. Despite the lack of early clinical symptoms, the applicant considered that GAA knockout mice provide a valuable tool f ...
2010 Newsletter
2010 Newsletter

... of Neurology at UCSF, in collaboration with Jorge Oksenberg, PhD, UCSF professor of neurology and was funded by Bill Perkins of Small Ventures USA Inc., Katie and AJ Brass of the A. J. Brass Foundation. Scientists are reporting what they say is compelling evidence that some powerful non-heritable, e ...
The Diagnosis and Treatment of Chronic Migraine
The Diagnosis and Treatment of Chronic Migraine

... Patients with chronic migraine often find it difficult to know when to take acute treatments. Both patients and physicians may be concerned about the possibility of medication overuse, and in the early stages of management it may be preferable to avoid acute painkillers altogether. Once a stage is r ...
fn_slide_set_12.13.12.pps
fn_slide_set_12.13.12.pps

... B) Among patients with a malignancy and febrile neutropenia: B-4) What clinical characteristics should be used to select patients for outpatient empiric therapy? B-5) Should outpatients with fever and neutropenia at lowrisk for medical complications receive their initial dose(s) of empiric antimicro ...
A Randomized Trial of Empiric Antibiotics and Invasive Diagnostic
A Randomized Trial of Empiric Antibiotics and Invasive Diagnostic

... ventilation for more than two days and were placed on vasopressor agents to support their blood pressure. • Patients divided according to whether or not they received enteral nutrition within 48 hours of mechanical ventilation onset. • 707 patients (60%) who did were labeled as the “early enteral nu ...
Calcium Channel Blocker Toxicity in a Cirrhotic Patient
Calcium Channel Blocker Toxicity in a Cirrhotic Patient

... his symptoms and verapamil administration [29]. Points were given for previous conclusive reports of this reaction, temporal relationship between drug administration and adverse event, improvement upon drug discontinuation and administration of an antagonist, worsening upon dose increase, and confir ...
Amyotrophic Lateral Sclerosis (ALS) Symptom Guidelines Hospice Palliative Care Program
Amyotrophic Lateral Sclerosis (ALS) Symptom Guidelines Hospice Palliative Care Program

... of control may lead to anxiety, anger, depression and controlling behaviour. Emotional lability and bouts of crying are common. Up to 50% of ALS patients have pseudobulbar effect, pathological uncontrolled bouts of laughing or crying not concordant with their mood.(1, 4, 8, 9) Families, friends and ...
P 2005 IDSA/ATS HOSPITAL-ACQUIRED PNEUMONIA GUIDELINES: NEW PRINCIPLES FOR IMPROVING MANAGEMENT ROCEEDINGS
P 2005 IDSA/ATS HOSPITAL-ACQUIRED PNEUMONIA GUIDELINES: NEW PRINCIPLES FOR IMPROVING MANAGEMENT ROCEEDINGS

Predictive Factors of Mortality From Nonvariceal Upper
Predictive Factors of Mortality From Nonvariceal Upper

... RESULTS: One thousand and twenty patients were included. A total of 46 patients died for an overall 4.5% mortality rate. In all, 85% of deaths were associated with one or more major comorbidity. Sixteen of 46 patients (35%) died within the first 24 h of the onset of bleeding. Of these, eight had bee ...
Avastin - Scottish Medicines Consortium
Avastin - Scottish Medicines Consortium

... compares to Cancer Registry data from patients in Scotland in 2004 where 73% and 59% of patients diagnosed with colorectal cancer were aged at least 65 years and at least 70 years respectively. It is possible that the benefits observed with bevacizumab in the pivotal trial may be different to those ...
Dissociative Identity Disorder: A Pathophysiological Phenomenon
Dissociative Identity Disorder: A Pathophysiological Phenomenon

... DID is a pathophysiological disorder. The patients suffering with DID have been found to have some alterations in their brain morphology. Amygdala and hippocampus have been found to be affected in DID as well. Usually the reduction in size of the hippocampus of DID patients is observed. Moreover, st ...
Dental Management of Patients Receiving Oral
Dental Management of Patients Receiving Oral

... It is important to reiterate that, based on the current literature and on the cases reported so far, a patient’s risk for developing BON is minute with oral bisphosphonate therapy as compared to intravenous bisphosphonate therapy in cancer patients. Accordingly, the majority of reported BON cases h ...
Dental Management of Patients Receiving Oral
Dental Management of Patients Receiving Oral

... It is important to reiterate that, based on the current literature and on the cases reported so far, a patient’s risk for developing BON is minute with oral bisphosphonate therapy as compared to intravenous bisphosphonate therapy in cancer patients. Accordingly, the majority of reported BON cases h ...
Neurology Ch. 65 - Porterville College
Neurology Ch. 65 - Porterville College

... With PD it is known which neurotransmitter is lacking in the brain and scientists are able to duplicate this neurotransmitter. Why are we then unable to cure PD? PD type deterioration of the nerve cells of the brain reduces the amount of what neurotransmitter? Because of the inability to cure PD at ...
me dicine the journal of personalized
me dicine the journal of personalized

... American College of Physicians and the American Pain Society recommend avoiding routine imaging and other diagnostic tests in ...
Nervous System Terminology Matching Worksheet
Nervous System Terminology Matching Worksheet

... _5____ lack of muscle coordination in the execution of voluntary movement _6____ developmental disorder characterized by extreme withdrawal and abnormal absorption in fantasy, usually characterized by the inability to communicate on a basic level _11___ injury to the brain, occasionally with transie ...
CONTINGENCY MANAGEMENT
CONTINGENCY MANAGEMENT

... The authors set out to assess the representativeness of participants in clinical trails of treatments for cocaine dependence noting that clinical trials have been criticized for being limited in external validity, with subjects usually not being representative of individuals seen in clinical practic ...
Bee venom therapy and Parkinson disease
Bee venom therapy and Parkinson disease

... model of Parkinson’s Disease, the results of which suggested that BV injection may have a neuro-protective effect that attenuates the activation of the microglial response, which has implications for the treatment of PD. ...
Eletriptan for the treatment of migraine in patients with previous poor
Eletriptan for the treatment of migraine in patients with previous poor

... The study was a double-blind, parallel-group, placebo-controlled, multicentre study comparing the efficacy, safety, and tolerability of oral eletriptan 40 mg (E40), oral eletriptan 80 mg (E80) and placebo (PBO). A total of 446 patients were randomized in a 2 : 2 : 1 ratio to E40 (n = 188), E80 (n = ...
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Management of multiple sclerosis



Several therapies for multiple sclerosis (MS) exist, although there is no known cure. Multiple sclerosis is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS).The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable attacks (relapses) followed by periods of relative remission with no new signs of disease activity. After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. When this happens it is called secondary progressive multiple sclerosis. Other, less common, courses of the disease are the primary progressive (decline from the beginning without attacks) and the progressive-relapsing (steady neurologic decline and superimposed attacks). Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS.The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. At the same time different alternative treatments are pursued by many patients, despite the paucity of supporting, comparable, replicated scientific study.This article focuses on therapies for standard MS; borderline forms of MS have particular treatments that are excluded.
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