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INSILICO Research Article S. AMUTHALAKSHMI* AND A. ANTON SMITH
... neutral. Their tolerability profile is good, and no specific adverse reactions have been reported. The DPP-IV binding site is highly druggable in the sense that tight, specific binding to the enzyme can be achieved with small molecules with drug-like physicochemical properties [14]. The two key bind ...
... neutral. Their tolerability profile is good, and no specific adverse reactions have been reported. The DPP-IV binding site is highly druggable in the sense that tight, specific binding to the enzyme can be achieved with small molecules with drug-like physicochemical properties [14]. The two key bind ...
San Diego scientists find Zika may infect adult brains too By David
... A study published Thursday in the journal Cell Stem Cell shows that the Zika virus can damage brain cells in a specific strain of adult lab mice. La Jolla Institute for Allergy and Immunology researcher Sujan Shresta co-led the study with Joseph Gleeson of the The Rockefeller University. "The vi ...
... A study published Thursday in the journal Cell Stem Cell shows that the Zika virus can damage brain cells in a specific strain of adult lab mice. La Jolla Institute for Allergy and Immunology researcher Sujan Shresta co-led the study with Joseph Gleeson of the The Rockefeller University. "The vi ...
2. Virtual Screening of Molecular Properties and Bioactivity Score of
... The calculated values of various parameters of the isolated compounds for drug likeness are presented in the table 1. Drug likeness evaluates whether a particular molecule is similar to the known drug or not. It is a complex balance of various properties and structural features of a compound. Lipins ...
... The calculated values of various parameters of the isolated compounds for drug likeness are presented in the table 1. Drug likeness evaluates whether a particular molecule is similar to the known drug or not. It is a complex balance of various properties and structural features of a compound. Lipins ...
What is the primary objective of medicinal chemistry ? Which
... Primary alcohols have 2, secondary alcohols 1 and tertiary alcohols have no H atoms. Alcohols are named with the name of total hydrocarbone name plus -ole ending or ...
... Primary alcohols have 2, secondary alcohols 1 and tertiary alcohols have no H atoms. Alcohols are named with the name of total hydrocarbone name plus -ole ending or ...
Bergamottin and “The Grapefruit Juice Effect”
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation; the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation; the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
SULFONAMIDES and TRIMETHOPRIM
... Trimethoprim may cause the predictable adverse effects of an antifolate drug, including ...
... Trimethoprim may cause the predictable adverse effects of an antifolate drug, including ...
enzymes-inhibition-text
... with the catalysis (e.g. by reacting with side-chains important for the catalysis); ...
... with the catalysis (e.g. by reacting with side-chains important for the catalysis); ...
October 12 AP Biology - John D. O`Bryant School of Math & Science
... C) Enzymes are used up in chemical reactions. D) Enzymes emerge unchanged from the reactions they ...
... C) Enzymes are used up in chemical reactions. D) Enzymes emerge unchanged from the reactions they ...
Drugs acting on digestive system
... nerve endings of norepinephrine and dopamine, and inhibits the reuptake of them. At the same time stimulates the central adrenergic receptors and dopamine receptors, leading to inhibition of the hunger center. In addition, amphetamine has a stimulating effect on the cerebral cortex, and perhaps seco ...
... nerve endings of norepinephrine and dopamine, and inhibits the reuptake of them. At the same time stimulates the central adrenergic receptors and dopamine receptors, leading to inhibition of the hunger center. In addition, amphetamine has a stimulating effect on the cerebral cortex, and perhaps seco ...
Weed 3: Weed establishment
... • Each MOA has a designated numerical system (WSSA) and alphabetical system (HRAC). ...
... • Each MOA has a designated numerical system (WSSA) and alphabetical system (HRAC). ...
Urinary Antiseptics
... Taken orally excreted unchanged in urine where these drugs are bactericidal for some Gm –ive bacteria when pH is less than 5.5 ...
... Taken orally excreted unchanged in urine where these drugs are bactericidal for some Gm –ive bacteria when pH is less than 5.5 ...
Palmitoylation of influenza virus proteins
... HA (or other viral proteins) has not been identified. Alternatively, S-acylation of proteins can occur via a non-enzymatic mechanism. Some cellular proteins are palmitoylated, at least in vitro, at authentic sites in the absence of any enzyme source [18,19]. In addition, peptides composed of unnatur ...
... HA (or other viral proteins) has not been identified. Alternatively, S-acylation of proteins can occur via a non-enzymatic mechanism. Some cellular proteins are palmitoylated, at least in vitro, at authentic sites in the absence of any enzyme source [18,19]. In addition, peptides composed of unnatur ...
Enzymes: The Biological Accelerators
... residue chain from the N-terminal of trypsinogen. This loss is accompanied by a change of conformation of the resultant protein to form the active form of the enzyme. Proenzymes allow the body to produce and control enzymes that could be harmful in the wrong place. E.g., trypsin catalyzes the breakd ...
... residue chain from the N-terminal of trypsinogen. This loss is accompanied by a change of conformation of the resultant protein to form the active form of the enzyme. Proenzymes allow the body to produce and control enzymes that could be harmful in the wrong place. E.g., trypsin catalyzes the breakd ...
letters Structure of -lactam synthetase reveals how to
... One CEA η-nitrogen is hydrogen bonded to the side chain of Glu 382, and both η-nitrogens are linked to the carbonyl oxygen of Asp 373 via a water molecule. The CEA Arg side chain is also held in position by the side chain of Tyr 326. The α-carboxylate of CEA is stabilized by interactions with the am ...
... One CEA η-nitrogen is hydrogen bonded to the side chain of Glu 382, and both η-nitrogens are linked to the carbonyl oxygen of Asp 373 via a water molecule. The CEA Arg side chain is also held in position by the side chain of Tyr 326. The α-carboxylate of CEA is stabilized by interactions with the am ...
Chapter 41 Tetracyclines and chloramphenicol
... hepatic insufficiency when high doses are given IV; (5) Photosensitivity, Especially demeclocycline. (6) Vestibular reactions, dizziness, vertigo, nausea, and vomiting, If using minocycline or doxycycline at high doses. ...
... hepatic insufficiency when high doses are given IV; (5) Photosensitivity, Especially demeclocycline. (6) Vestibular reactions, dizziness, vertigo, nausea, and vomiting, If using minocycline or doxycycline at high doses. ...
Bergamottin and “The Grapefruit Juice Effect”
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation, the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
... during inactivation by using SDS PAGE and the masses of the apoproteins were analyzed by ESI-LC-MS 2. It was found that oxidation of a double bond in the furan ring is responsible for inactivation, the irreversible inactivation of CYP450 3A4 catalytic activity is due to a mono-oxygenated reactive me ...
Uses
... – They do not penetrate well into tissues and bone and do not cross the blood-brain barrier. – Intrathecal administration of streptomycin is used in treatment of tuberculous meningitis, and gentamicin may be administered by this route for the treatment of gram-negative meningitis in neonates. – Amin ...
... – They do not penetrate well into tissues and bone and do not cross the blood-brain barrier. – Intrathecal administration of streptomycin is used in treatment of tuberculous meningitis, and gentamicin may be administered by this route for the treatment of gram-negative meningitis in neonates. – Amin ...
Hutational analysis of the influenza virus A/Victoria/3/75 PA protein
... deletion mutants showed binding to PB1 it might be concluded that the entire C-terminal three quarters of PA are involved in this association. PBI may be bound at several points and/or by a highly structure-dependent element formed by discontinuous regions of PA. The structure is indeed important si ...
... deletion mutants showed binding to PB1 it might be concluded that the entire C-terminal three quarters of PA are involved in this association. PBI may be bound at several points and/or by a highly structure-dependent element formed by discontinuous regions of PA. The structure is indeed important si ...
Biological characterisation of the emerged highly pathogenic avian
... recently recommended SF003 as an additional candidate vaccine virus. Among the four commercially available NAIs, oseltamivir and zanamivir are the predominant NAIs for influenza prophylaxis and treatment [13]. Our results show that HPAI H7N9 viruses with the 292K amino acid in the NA protein exhibi ...
... recently recommended SF003 as an additional candidate vaccine virus. Among the four commercially available NAIs, oseltamivir and zanamivir are the predominant NAIs for influenza prophylaxis and treatment [13]. Our results show that HPAI H7N9 viruses with the 292K amino acid in the NA protein exhibi ...
Anti-HIV drugs: 25 compounds approved within 25 years after the
... recognised as specific inhibitors of HIV-1, interacting with an allosteric (that is non-catalytic) site of the HIV-1 RT [14]. Remarkable similarities were discerned in the structural features of the HEPT and TIBO derivatives that allowed a superposition of the prototypes of these two classes of comp ...
... recognised as specific inhibitors of HIV-1, interacting with an allosteric (that is non-catalytic) site of the HIV-1 RT [14]. Remarkable similarities were discerned in the structural features of the HEPT and TIBO derivatives that allowed a superposition of the prototypes of these two classes of comp ...
Antiviral drugs
... They must be phosphorylated by viral or cellular enzymes in order to become active. - Antiviral drugs typically have a restricted spectrum of antiviral activity and inhibit a specific viral protein, most often an enzyme involved in viral nucleic acid synthesis. - Single nucleotide changes leading to ...
... They must be phosphorylated by viral or cellular enzymes in order to become active. - Antiviral drugs typically have a restricted spectrum of antiviral activity and inhibit a specific viral protein, most often an enzyme involved in viral nucleic acid synthesis. - Single nucleotide changes leading to ...
Enzyme Inhibition and Drug Action
... Inhib. and substrate very different structures Difficult to design inhib. ...
... Inhib. and substrate very different structures Difficult to design inhib. ...
Poster for RCPSC mee.. - University of Alberta
... Ceramide is a sphingolipid second messenger produced in response to cellular stress via activation of sphingomyelinases. Agonists that cause cellular production of ceramide include cytokines (TNF, Fas), agents of environmental stress (heat, UV irradiation), and chemotherapeutic agents. The accumulat ...
... Ceramide is a sphingolipid second messenger produced in response to cellular stress via activation of sphingomyelinases. Agonists that cause cellular production of ceramide include cytokines (TNF, Fas), agents of environmental stress (heat, UV irradiation), and chemotherapeutic agents. The accumulat ...
HIV Protease Inhibitor: Past Endeavors and Future Developments
... ineffective. There are two types of mutations: primary and secondary. First of all, primary mutations involve changes in amino acid sequence within the active site of the enzyme and significantly affect the binding of the inhibitor to the mutant active site. Secondary mutations take place outside o ...
... ineffective. There are two types of mutations: primary and secondary. First of all, primary mutations involve changes in amino acid sequence within the active site of the enzyme and significantly affect the binding of the inhibitor to the mutant active site. Secondary mutations take place outside o ...