The Serotonin Syndrome - Department of Psychiatry
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
... akinesia, “lead pipe” muscular rigidity, hyperthermia, fluctuating consciousness, and autonomic instability.44 Signs and symptoms of the neuroleptic malignant syndrome typically evolve during several days, in contrast to the rapid onset and hyperkinesia of the serotonin syndrome. Knowledge of the pr ...
Aalborg Universitet
... It is obvious that the use of pharmaceuticals is only acceptable if no side effects occur. Additionally, medical products are accepted if their side effects are tolerable when compared to the benefits associated with their use. In order to avoid safety problems, drugs must undergo a thorough approva ...
... It is obvious that the use of pharmaceuticals is only acceptable if no side effects occur. Additionally, medical products are accepted if their side effects are tolerable when compared to the benefits associated with their use. In order to avoid safety problems, drugs must undergo a thorough approva ...
Pharmacological and Pharmaceutical Profile of Gliclazide: A Review
... secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action. All may cause hypoglycaemia but this is uncommon and usually indicates excessive dosage. Sulphonylurea-induced hypoglyc ...
... secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action. All may cause hypoglycaemia but this is uncommon and usually indicates excessive dosage. Sulphonylurea-induced hypoglyc ...
PDF full-Text - Journal of Investigational Allergology and Clinical
... that has not been fully elucidated, though it is postulated that drugs or other substances pass through a hydrophobic pore structure composed of a transmembrane domain, requiring an energy-dependent conformation change in the protein structure. A second hypothesis proposed to explain how PgP is able ...
... that has not been fully elucidated, though it is postulated that drugs or other substances pass through a hydrophobic pore structure composed of a transmembrane domain, requiring an energy-dependent conformation change in the protein structure. A second hypothesis proposed to explain how PgP is able ...
Antibiotics
... ○ Distributes into all tissues and fluids (including bones) ■ Means can inhibit cartilage and tendon damage leading to tendonitis and tendon rupture in adults ■ Means can be used for Salmonella osteomyelitis ■ Means contraindicated in pregnancy and in children ○ Respiratory fluoroquinolones (levoflo ...
... ○ Distributes into all tissues and fluids (including bones) ■ Means can inhibit cartilage and tendon damage leading to tendonitis and tendon rupture in adults ■ Means can be used for Salmonella osteomyelitis ■ Means contraindicated in pregnancy and in children ○ Respiratory fluoroquinolones (levoflo ...
Revisiting the Isobole and Related Quantitative Methods for
... this same combination by using motor and sensory responses in the rat. [Leu5]-enkephalin, which has no detectable antinociception action in mice, was studied by Porreca et al. (1990) for its combinations with morphine in the hot water test. Raffa et al. (1993), in a most interesting study, tested co ...
... this same combination by using motor and sensory responses in the rat. [Leu5]-enkephalin, which has no detectable antinociception action in mice, was studied by Porreca et al. (1990) for its combinations with morphine in the hot water test. Raffa et al. (1993), in a most interesting study, tested co ...
The effects of herbal teas on drug permeability
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
... Inhibition and induction of the metabolic enzyme CYP can also affect the pharmacokinetics of treatment with these medications. This should be of concern since CYP3A4 is associated with the metabolism of many drugs. It is well known that there is overlap in the substrate specificities of CYP3A4 and P ...
Ignatowska-Jankowska et al, 2014
... arachidoloylglycerol; 2-AG) are released on demand in response to various stimuli, including pain. Through their stimulation of CB1 receptors, they inhibit pain transmission at central, spinal and peripheral synapses and may serve an auto protective role (Walker et al, 1999). While preclinical data ...
... arachidoloylglycerol; 2-AG) are released on demand in response to various stimuli, including pain. Through their stimulation of CB1 receptors, they inhibit pain transmission at central, spinal and peripheral synapses and may serve an auto protective role (Walker et al, 1999). While preclinical data ...
Professional Perspectives On Addiction Medicine
... Remnants of hemp ropes have been found in Iceland, carried there by the Vikings who were seeking other places to locate their homes. Cannabis seeds and cloth made of hemp have been found on Viking ships that have been dated to the 9th Century. The Italians were also a formidable sea power during the ...
... Remnants of hemp ropes have been found in Iceland, carried there by the Vikings who were seeking other places to locate their homes. Cannabis seeds and cloth made of hemp have been found on Viking ships that have been dated to the 9th Century. The Italians were also a formidable sea power during the ...
Inhaled loxapine: A novel treatment for agitation in psychotic disorders
... in order to manage the high risk of violence by a patient. This, in turn, is a prerequisite of providing safety for a patient him- or herself, as well as all the other individuals involved in the emergency situation (i.e. staff members, other patients, and hospital guests) [3-6]. It is also worth me ...
... in order to manage the high risk of violence by a patient. This, in turn, is a prerequisite of providing safety for a patient him- or herself, as well as all the other individuals involved in the emergency situation (i.e. staff members, other patients, and hospital guests) [3-6]. It is also worth me ...
MODIFIED RELEASE DOSAGE FORM
... Modified release dosage forms are drug delivery systems (DDS) which, by virtue of formulation and product design, provide drug release in a modified form distinct from that of the conventional dosage forms. Drug release can either be delayed or extended in nature. ...
... Modified release dosage forms are drug delivery systems (DDS) which, by virtue of formulation and product design, provide drug release in a modified form distinct from that of the conventional dosage forms. Drug release can either be delayed or extended in nature. ...
PRODUCT MONOGRAPH
... trials for its potential for abuse, no indication of drug-seeking behavior was seen in the clinical trials. Discontinuation Symptoms At the time that a medical decision is made to discontinue PRISTIQ, a gradual reduction in the dose, rather than an abrupt cessation, is recommended. During marketing ...
... trials for its potential for abuse, no indication of drug-seeking behavior was seen in the clinical trials. Discontinuation Symptoms At the time that a medical decision is made to discontinue PRISTIQ, a gradual reduction in the dose, rather than an abrupt cessation, is recommended. During marketing ...
Vitex agnus
... genital system. In actual clinical trials, the fruit Agni casti fructus was shown to relieve premenstrual syndrome (PMS) and especially breast swelling and pain, due to its dopaminergic effect. Although approximately 50% or more of young women suffer from PMS, there is no generally accepted therapy ...
... genital system. In actual clinical trials, the fruit Agni casti fructus was shown to relieve premenstrual syndrome (PMS) and especially breast swelling and pain, due to its dopaminergic effect. Although approximately 50% or more of young women suffer from PMS, there is no generally accepted therapy ...
Special Considerations for Unused Drugs Subject to Restricted
... • Absent proper precautions, some proposed solutions could circumvent FDA-mandated restricted distribution programs and create serious health risks for patients or others – Drug Collection and Takeback Programs – Drug Repository/Reuse Programs Presented at the 2008 International Symposium on Pharmac ...
... • Absent proper precautions, some proposed solutions could circumvent FDA-mandated restricted distribution programs and create serious health risks for patients or others – Drug Collection and Takeback Programs – Drug Repository/Reuse Programs Presented at the 2008 International Symposium on Pharmac ...
Peer-reviewed Article PDF
... the traditional and current uses of M. speciosa and related plants. The Internet availabilities of various genuine or fake kratom preparations, including the ominous ‘Krypton’ product dangerously adulterated with the synthetic opioid O-desmethyltramadol, are also discussed here. Chapter 6 is an outs ...
... the traditional and current uses of M. speciosa and related plants. The Internet availabilities of various genuine or fake kratom preparations, including the ominous ‘Krypton’ product dangerously adulterated with the synthetic opioid O-desmethyltramadol, are also discussed here. Chapter 6 is an outs ...
Marijuana Presentation 2014
... Eating marijuana ("edibles") is perhaps a more obvious means to reduce the respiratory effects when using the drug. Oral administration carries its own challenges, however, as it typically takes longer for the effects of the drug to appear (30–60 minutes compared to seconds), making it more difficul ...
... Eating marijuana ("edibles") is perhaps a more obvious means to reduce the respiratory effects when using the drug. Oral administration carries its own challenges, however, as it typically takes longer for the effects of the drug to appear (30–60 minutes compared to seconds), making it more difficul ...
Glucocorticosteroids
... per day). Thiazide diuretics increase calcium reabsorption. Steroids are the most common cause of drug-induced osteoporosis. Steroids can lead to peptic ulcerations due to increased output and a decreased synthesis of mucopolysaccharides. There is an increased risk with NSAID uses when total doses a ...
... per day). Thiazide diuretics increase calcium reabsorption. Steroids are the most common cause of drug-induced osteoporosis. Steroids can lead to peptic ulcerations due to increased output and a decreased synthesis of mucopolysaccharides. There is an increased risk with NSAID uses when total doses a ...
Chapter 16 Cholinesterase Inhibitors
... Used for treatment of gastric and duodenal ulcers Not used for treatment of allergies ...
... Used for treatment of gastric and duodenal ulcers Not used for treatment of allergies ...
The Influence of Chronic Exposure to
... 2003; Pantelis et al, 2003; Sporn et al, 2003) that are potentially related to disease progression, but that might also reflect an effect of treatment. In addition to their effects on the brain in vivo (eg druginduced changes in cell number in a given brain region), antipsychotic drugs might also in ...
... 2003; Pantelis et al, 2003; Sporn et al, 2003) that are potentially related to disease progression, but that might also reflect an effect of treatment. In addition to their effects on the brain in vivo (eg druginduced changes in cell number in a given brain region), antipsychotic drugs might also in ...
The Absorption, Distribution, and Excretion of Drugs
... site of action. When a tablet or capsule is swallowed it must dissolve before it can be absorbed. The dissolving of a tablet or capsule is referred to as dissolution. Manufacturing processes and the water solubility of the drug affect dissolution rates. Highly water-soluble medications dissolve more ...
... site of action. When a tablet or capsule is swallowed it must dissolve before it can be absorbed. The dissolving of a tablet or capsule is referred to as dissolution. Manufacturing processes and the water solubility of the drug affect dissolution rates. Highly water-soluble medications dissolve more ...
PDF
... results in a different drug sensitivity and the species-specific AP shape and duration. Moreover, the higher the assay complexity, the more difficult it is to interpret the results. Furthermore, even the best animal model is unable to account for the inter-individual variability, while the strains a ...
... results in a different drug sensitivity and the species-specific AP shape and duration. Moreover, the higher the assay complexity, the more difficult it is to interpret the results. Furthermore, even the best animal model is unable to account for the inter-individual variability, while the strains a ...
ARF in Sepsis
... A randomized crossover trial compared 24-h continuous arteriovenous hemofiltration with a 24h period encompassing a 4-h IHD session in 27 critically ill patients and found no difference in the incidence of BP drops and vasopressor ...
... A randomized crossover trial compared 24-h continuous arteriovenous hemofiltration with a 24h period encompassing a 4-h IHD session in 27 critically ill patients and found no difference in the incidence of BP drops and vasopressor ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.