Steroid Hormones
... - Progesterone receptor antagonist of the uterus - Promotes shedding of endometrium, softening of the cervix, and uterine contractions leading to ...
... - Progesterone receptor antagonist of the uterus - Promotes shedding of endometrium, softening of the cervix, and uterine contractions leading to ...
lipids - UNT Chemistry
... estimated that a 60 kg person has a total of about 175 g of cholesterol distributed throughout the body. Much of this cholesterol is bonded through ester links to fatty acids, but some is found as the free alcohol. Gallstones, for example, are nearly purecholesterol. • Cholesterol serves two importa ...
... estimated that a 60 kg person has a total of about 175 g of cholesterol distributed throughout the body. Much of this cholesterol is bonded through ester links to fatty acids, but some is found as the free alcohol. Gallstones, for example, are nearly purecholesterol. • Cholesterol serves two importa ...
Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5
... affinities for Hsp90 by ITC or to obtain protein ligand crystal structures presumably because they bind so weakly. There are two possible explanations for this drop in affinity. The first is the electronic impact that a fluorine atom has on the two phenolic groups and the carbonyl of the tertiary am ...
... affinities for Hsp90 by ITC or to obtain protein ligand crystal structures presumably because they bind so weakly. There are two possible explanations for this drop in affinity. The first is the electronic impact that a fluorine atom has on the two phenolic groups and the carbonyl of the tertiary am ...
Macrocycles in new drug discovery
... -26.4 ± 1.59 kJmol-1). From analysis of x-ray cocrystal structures of 1 and 2 , the authors found that the bound linear peptide 1 in fact formed an intramolecular hydrogen bond between the carbonyl oxygen of the phosphotyrosine residue and the NH of the valine residue, while the corresponding inter ...
... -26.4 ± 1.59 kJmol-1). From analysis of x-ray cocrystal structures of 1 and 2 , the authors found that the bound linear peptide 1 in fact formed an intramolecular hydrogen bond between the carbonyl oxygen of the phosphotyrosine residue and the NH of the valine residue, while the corresponding inter ...
Selective Serotonin Reuptake Inhibitors (SSRIs) with Dual
... combining the pharmacophoric profiles of 5-HT reuptake inhibition with 5HT1B/1D antagonism in one molecule can be conducted via: I) Modification of already existed hybrid molecules previously made by other research groups or II) the tethering technique or fragment based drug discovery. Tethering tec ...
... combining the pharmacophoric profiles of 5-HT reuptake inhibition with 5HT1B/1D antagonism in one molecule can be conducted via: I) Modification of already existed hybrid molecules previously made by other research groups or II) the tethering technique or fragment based drug discovery. Tethering tec ...
HTN.SFGH.April_.2012..
... Very effective for systolic BP Do not increase sudden death Most effective in LVH regression Lipid effects are short lasting (1 y) Hyperglycemia only in high doses Still effective in early chronic kidney disease (to GFR 40-45) • Erectile dysfunction in 20% • More effective in Blacks and older ...
... Very effective for systolic BP Do not increase sudden death Most effective in LVH regression Lipid effects are short lasting (1 y) Hyperglycemia only in high doses Still effective in early chronic kidney disease (to GFR 40-45) • Erectile dysfunction in 20% • More effective in Blacks and older ...
Tuberculosis - ichapps.com
... mycobacterium, with a MIC against M. tuberculosis of 0.01 to 0.25 mcg/mL. Most nontuberculous mycobacterium such as M. avium is resistant to Isoniazid. Isoniazid is readily absorbed from the GI tract and from intramuscular injection sites. Isoniazid should be given on an empty stomach whenever poss ...
... mycobacterium, with a MIC against M. tuberculosis of 0.01 to 0.25 mcg/mL. Most nontuberculous mycobacterium such as M. avium is resistant to Isoniazid. Isoniazid is readily absorbed from the GI tract and from intramuscular injection sites. Isoniazid should be given on an empty stomach whenever poss ...
PARKINSON*S DISEASE
... • Typically late effect, and with higher doses • Narrowing of therapeutic window • Rare in LD-naive patients on DA monotherapy • Most common is “peak dose” dyskinesia – disappears with dose reduction • Choreiform, ballistic and dystonic movements • Most patients prefer some dyskinesias over the alte ...
... • Typically late effect, and with higher doses • Narrowing of therapeutic window • Rare in LD-naive patients on DA monotherapy • Most common is “peak dose” dyskinesia – disappears with dose reduction • Choreiform, ballistic and dystonic movements • Most patients prefer some dyskinesias over the alte ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.