Log P
... To determine σ* Taft studied the hydrolysis of methyl esters (RCOOMe). The hydrolysis of esters can occur through either acid and base catalyzed mechanisms, both of which proceed through a tetrahedral intermediate. In the base catalyzed mechanism the reactant goes from a neutral species to negat ...
... To determine σ* Taft studied the hydrolysis of methyl esters (RCOOMe). The hydrolysis of esters can occur through either acid and base catalyzed mechanisms, both of which proceed through a tetrahedral intermediate. In the base catalyzed mechanism the reactant goes from a neutral species to negat ...
Telenzepine is at least 25 times more potent than pirenzepine
... and of 50 mg pirenzepine (p_0-01). On a molar basis telenzepine proved to be about 25 times more potent than pirenzepine to inhibit acid output. Mean peptone volumes which had to be added during the secretory studies did not show significant differences within the test with pirenzepine or telenzepin ...
... and of 50 mg pirenzepine (p_0-01). On a molar basis telenzepine proved to be about 25 times more potent than pirenzepine to inhibit acid output. Mean peptone volumes which had to be added during the secretory studies did not show significant differences within the test with pirenzepine or telenzepin ...
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
... is metabolized by that enzyme Some substrates for a particular enzyme are also inhibitors or inducers of that same enzyme Some inhibitors affect more than one enzyme Magnitude of inhibition may depend upon the dose ...
... is metabolized by that enzyme Some substrates for a particular enzyme are also inhibitors or inducers of that same enzyme Some inhibitors affect more than one enzyme Magnitude of inhibition may depend upon the dose ...
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
... is metabolized by that enzyme Some substrates for a particular enzyme are also inhibitors or inducers of that same enzyme Some inhibitors affect more than one enzyme Magnitude of inhibition may depend upon the dose ...
... is metabolized by that enzyme Some substrates for a particular enzyme are also inhibitors or inducers of that same enzyme Some inhibitors affect more than one enzyme Magnitude of inhibition may depend upon the dose ...
Peptide Conjugation via CuAAC `Click` Chemistry
... ligation factory within living cells, amino acids are conjugated to one another with the help of transfer RNA (tRNA). The resultant proteins perform crucial roles in living organisms, serving as enzymes, structural proteins, signaling proteins etc. The broad spectrum of biological activities has mad ...
... ligation factory within living cells, amino acids are conjugated to one another with the help of transfer RNA (tRNA). The resultant proteins perform crucial roles in living organisms, serving as enzymes, structural proteins, signaling proteins etc. The broad spectrum of biological activities has mad ...
Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase
... conducted to examine the role of polymorphisms in CYP enzymes and their relationship with intersubject variability in efficacy and neurotoxicity. Recent reports suggest that while CYP2C8*3 is associated with a higher rate of clinical responses, it is also correlated with an increased risk for neurot ...
... conducted to examine the role of polymorphisms in CYP enzymes and their relationship with intersubject variability in efficacy and neurotoxicity. Recent reports suggest that while CYP2C8*3 is associated with a higher rate of clinical responses, it is also correlated with an increased risk for neurot ...
the chembiobank and eu-openscreen initiatives in chemical
... The Chembiobank initiative in Spain (CBB, http://www.pcb.ub.cat/chembiobank/) has built a chemico-biological library and annotated database, which will be described. The library contains nearly 15.000 compounds both from commercial and from academic origins. The annotated database has been developed ...
... The Chembiobank initiative in Spain (CBB, http://www.pcb.ub.cat/chembiobank/) has built a chemico-biological library and annotated database, which will be described. The library contains nearly 15.000 compounds both from commercial and from academic origins. The annotated database has been developed ...
Review Pharmacodynamic and pharmacokinetic interactions
... Drug interactions between herbal and prescription medicines Interactions between herbal and prescription medications may be caused by either pharmacodynamic or pharmacokinetic mechanism. Pharmacodynamic interactions may occur when constituents of herbal products have either synergistic or antagonist ...
... Drug interactions between herbal and prescription medicines Interactions between herbal and prescription medications may be caused by either pharmacodynamic or pharmacokinetic mechanism. Pharmacodynamic interactions may occur when constituents of herbal products have either synergistic or antagonist ...
59d16bf7bdb2d33
... this because basic solvent has a higher affinity to take up protons from the acid. So acetic acid behaves as a strong acid in ammonia solution (basic solvent). Also the basicity of weak bases can be enhanced in presence of acidic solvent. This is called the leveling effect of the solvent. By using t ...
... this because basic solvent has a higher affinity to take up protons from the acid. So acetic acid behaves as a strong acid in ammonia solution (basic solvent). Also the basicity of weak bases can be enhanced in presence of acidic solvent. This is called the leveling effect of the solvent. By using t ...
High Blood Pressure - Summary of JNC Six
... Home BP measurement Care inexpensive / simple (long acting) Encourage lifestyle modifications Least side effects possible - monitor / change when needed • Encourage positive attitude! • Visits with nurse / teams --------------------High Blood Pressure - JNC 6-------------------- ...
... Home BP measurement Care inexpensive / simple (long acting) Encourage lifestyle modifications Least side effects possible - monitor / change when needed • Encourage positive attitude! • Visits with nurse / teams --------------------High Blood Pressure - JNC 6-------------------- ...
Hit discovery and hit-to-lead approaches
... Such compounds have been pinpointed by repeated biochemical screenings at different protein concentrations or with additives such as detergents [19]. Alternatively, dynamic light-scattering readings can be used to look for large aggregate particles in biological buffer systems [33]. Counterscreens h ...
... Such compounds have been pinpointed by repeated biochemical screenings at different protein concentrations or with additives such as detergents [19]. Alternatively, dynamic light-scattering readings can be used to look for large aggregate particles in biological buffer systems [33]. Counterscreens h ...
Methylergonovine Maleate Injection, USP (0.2 mg/ml)
... depression, hypothermia, convulsions, and coma. Because reports of overdosage with methylergonovine maleate are infrequent, the lethal dose in humans has not been established. The oral LD50 (in mg/kg) for the mouse is 187, the rat 93, and the rabbit 4.52. Several cases of accidental methylergonovine ...
... depression, hypothermia, convulsions, and coma. Because reports of overdosage with methylergonovine maleate are infrequent, the lethal dose in humans has not been established. The oral LD50 (in mg/kg) for the mouse is 187, the rat 93, and the rabbit 4.52. Several cases of accidental methylergonovine ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.