(5-Hydroxytryptamine 3).
... Ondansetron was first drug of this group. 4 drugs: ondansetron, granisetron, dolestron and palonsetron (all end in TRON). Polonsetron has the longest half-life (40 hours) and is given 30 minutes prior to chemotherapy in the same IV access. Drug action begins rapidly Characteristic Differences h-Hydr ...
... Ondansetron was first drug of this group. 4 drugs: ondansetron, granisetron, dolestron and palonsetron (all end in TRON). Polonsetron has the longest half-life (40 hours) and is given 30 minutes prior to chemotherapy in the same IV access. Drug action begins rapidly Characteristic Differences h-Hydr ...
Antihypertensive Agents
... release of aldosterone. Aldosterone promotes Na retention & K excretion. Block aldosterone & Na excreted, but H2O & K retained - Used to treat HTN primarily, - but not a 1st line drug. Also used in heart failure. - SE = hyperkalemia & 1st dose hypotension (more common with comb. Diuretic & ACE inhib ...
... release of aldosterone. Aldosterone promotes Na retention & K excretion. Block aldosterone & Na excreted, but H2O & K retained - Used to treat HTN primarily, - but not a 1st line drug. Also used in heart failure. - SE = hyperkalemia & 1st dose hypotension (more common with comb. Diuretic & ACE inhib ...
De novo structure-based ligand design software
... SPROUT is an effective tool for the design of drug-like, biologically active molecules. It is an interactive system that can assist in several stages of the structure-based rational drug design process. The system is modularised and offers automatic methods for solving a number of problems in drug d ...
... SPROUT is an effective tool for the design of drug-like, biologically active molecules. It is an interactive system that can assist in several stages of the structure-based rational drug design process. The system is modularised and offers automatic methods for solving a number of problems in drug d ...
Week 6 lecture slides
... competitively inhibits ethanol binding to the GABAA receptor complex. In vivo, Ro 154513 inhibits the sedation caused by alcohol but does not interfere with the anxiety relief caused by alcohol. ...
... competitively inhibits ethanol binding to the GABAA receptor complex. In vivo, Ro 154513 inhibits the sedation caused by alcohol but does not interfere with the anxiety relief caused by alcohol. ...
Possible Test Questions
... - M1 – Muscarinic cholinergic receptors – blockade of these receptors leads to many common side effects fitting into the classic anti-cholinergic caterogory - such as dry mouth, constipation, blurred vision. - 5-HT receptors = The Serotonin Receptors modulate the release of many other neurotransmi ...
... - M1 – Muscarinic cholinergic receptors – blockade of these receptors leads to many common side effects fitting into the classic anti-cholinergic caterogory - such as dry mouth, constipation, blurred vision. - 5-HT receptors = The Serotonin Receptors modulate the release of many other neurotransmi ...
Antihypertensive-Drugs.15.Mar.2011
... Increase of Na+ and decrease of K+ excretion in kidney Decrease noradrenaline release reduction of sympathetic activity (use is not associated with reflex tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left vent ...
... Increase of Na+ and decrease of K+ excretion in kidney Decrease noradrenaline release reduction of sympathetic activity (use is not associated with reflex tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left vent ...
Adverse Effects
... Fosinopril is the only ACE that contains a phosphinate group that binds to active site of ACE. It is a prodrug which is transformed to fosinoprilat, an ACE inhibitor which is more potent than captopril yet less potent than enalaprilat. It is metabolised and excreted into both the urine and bile. It ...
... Fosinopril is the only ACE that contains a phosphinate group that binds to active site of ACE. It is a prodrug which is transformed to fosinoprilat, an ACE inhibitor which is more potent than captopril yet less potent than enalaprilat. It is metabolised and excreted into both the urine and bile. It ...
Acute Coronary Syndrome Therapeutic Intervention
... 2. In order to activate the plasminogen into its active form; Plasmin, human kidneys secrete an enzyme called Urokinase. Urokinase will cleave the Plasminogen to Plasmin through proteolytic mechanism 3. Nevertheless, activated plasmin is vulnerable to be deactivated by plasma AntiPlasmin which can r ...
... 2. In order to activate the plasminogen into its active form; Plasmin, human kidneys secrete an enzyme called Urokinase. Urokinase will cleave the Plasminogen to Plasmin through proteolytic mechanism 3. Nevertheless, activated plasmin is vulnerable to be deactivated by plasma AntiPlasmin which can r ...
