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PIO Nas - Badan Pengawas Obat dan Makanan
PIO Nas - Badan Pengawas Obat dan Makanan

... (2) Nasea OD Tablet should only be used to treat severe nausea and vomiting associated with carcinostatics (such as cisplastin). (3) Nasea OD Tablet should be used mainly for preventing nausea and vomiting when carcinostatics (such as cisplastin) that causes these reactions are administered. Nasea I ...
Psychopharmacology Quiz-I
Psychopharmacology Quiz-I

... ------------------------------------------------------------------------------------------------------------------------ ------------45. A psychotropic drug commonly used in Tourette disorder is A. Haloperidol C. L-tryptophan B. Phenelzine D. Mianserin ----------------------------------------------- ...
Histamine and Antihistamines
Histamine and Antihistamines

... 3. Allergic dermatoses: can control itching associated with insect bites. 4. Outpatient procedures for preanesthetic sedation and prevention of nausea and vomiting (Promethazine (Phenergan)). Phenergan also inhibits salivary and bronchial secretions and can be used as a local anesthetic. 5. Antiemet ...
lecture6-Quantitative aspect of drugs 12-132014-08
lecture6-Quantitative aspect of drugs 12-132014-08

... 1.The max efficacy (Emax) → highest limit of dose-response relationship on response axis. 2.The potency = The concentration of drug required to produce a specified response The smaller the EC50 , the greater the potency of the agonist, i.e the lower C needed to elicit the maximum biological response ...
Positron Emission Tomography Imaging: A Quantitative Biomarker in
Positron Emission Tomography Imaging: A Quantitative Biomarker in

... measurement of tracer uptake and retention in blood and urine, allowing the production of models of the uptake in various body organs, even without direct measurement of the concentration in various organs. In PET, many of the mathematical equations used are similar, but the structure of the model i ...
A Comparative Study Between Palonosetron and Granisetron to
A Comparative Study Between Palonosetron and Granisetron to

... Then our study drugs were injected by an anaesthesiologist who was not involved in the study. Group A received Inj. Granisetron hydrochloride 45 g/kg body weight intravenous and Group B received Inj. Palonosetron hydrochloride 1.5 g/kg body weight intravenous, both diluted in 0.9% NS to make a to ...
CNS Depressants - Wayne State University
CNS Depressants - Wayne State University

...  Anterograde amnesia—may have blackouts up to 24hr periods  Fast acting 15-20 min  Mech of axn= GABA mediated—results in intox, rapid onset, sedation (lasts 3-8hrs)  Not detected by normal tox screen  Intox/OD may include respiratory distress, loss of consciousness Dissociatives—Ketamine, PCP, ...
Benzodiazepine Pharmacology and Central Nervous System
Benzodiazepine Pharmacology and Central Nervous System

... generally necessary for an agent to be eliminated from the body, making the number of hours that a drug is in the body considerably longer. The table lists various BZDs and their characteristics.2 Another way to characterize BZDs is by relative potency. The first BZDs were low to medium potency. The ...
Guidelines for Prevention and Treatment of Chemotherapy
Guidelines for Prevention and Treatment of Chemotherapy

... dose plus palonosetron and dexamethasone for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. Cancer 2008;112:2080-7. 13. FDA Drug Safety Communication: Abnormal heart rhythms may be associated with use of Zofran (ondansetron) 09-15-2011. Accessed 10 Nov 2011 at: http:// ...
View Abstract - Journal of Scientific and Innovative Research
View Abstract - Journal of Scientific and Innovative Research

... Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT1) receptor that is indicated for the treatment of essential hypertension. It selectively inhibits stimulation of the AT1 receptor by angiotensin II without affecting other receptor systems involved in cardi ...
PCP & Ketamine
PCP & Ketamine

... • Research demonstrated dose escalation and compulsive use • Many ketamine dependent subjects studied were described as highly intelligent • Overcoming ketamine was described as “harder than heroin” ...
Principles of Psychopharmacology in Children And Adolescents
Principles of Psychopharmacology in Children And Adolescents

... • Excess stimulation of these neurons occurs in seizures/stroke resulting in neuronal death • NMDAR PCP site blockade ---> psychosis • Hippocampus- NMDAR crucial for LTP • Substances binding at the NMDAR glycine site, (glycine, d-cycloserine) are associated with reduction in psychosis/negative sympt ...
Document
Document

PAIN AND OPIOID ANALGESICS
PAIN AND OPIOID ANALGESICS

... except: A)  – analgesia and respiratory depression; B) k – analgesia and dysphoria; C)  – miosis and physical dependence; D)  - euphoria and reduced GIT motility. 2. Which of the following analgesics are strong opioid receptor agonists? A) Morphine; B) Pethidine; C) Buprenorphine; D) Fentanyl. 3. ...
BuSpar (buspirone)
BuSpar (buspirone)

... barbiturates. In addition, unlike those medications, BuSpar neither produces prominent sedation nor significantly interferes with memory or cognition. The major advantage of BuSpar is its low abuse potential. It is not regulated as a controlled medication like the benzodiazepines and barbiturates. I ...
Document
Document

... other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the effect of Salbutamol can take place within 5 to 20 minutes of dosing. Salbutamol can also be given orally or intravenously. However, some asthmatics may not respond to these medications as they will not ...
DRUG RECEPTOR AND PHARMCODYNAMICS
DRUG RECEPTOR AND PHARMCODYNAMICS

... The body function increase or potentiated by the drug. Adrenaline accelerate the heart rate and output. With the dose increase of the drug it may induce augmentation. For example, overdose of adrenaline may cause heart failure. The selectivity of drug action It is also called electivity or specifici ...
nektar - Moodle Lille 2
nektar - Moodle Lille 2

... • Significant business: in 2005, sales for Pegyleted proteins amounted to more than $5 billion • PEGylation create blockbusters products, such as PEG-Intron® and Pegasys® • Improve the pharmacological property of a drug, but it has also has to be considered as a life cycle ...
Determination and Characterization of a Cannabinoid Receptor in
Determination and Characterization of a Cannabinoid Receptor in

... by a G protein. The binding was also sensitive to MgCI2 and CaCI2. Binding of [3H]CP-55,940 was displaced by cannabinoid drugs in the following order of potency: CP-55,940 ...
The Autonomic Nervous System
The Autonomic Nervous System

... • α2 Receptors are also found on presynpatic parasympathetic neurons. Norepinephrine can diffuse and interact with these receptors, inhibiting acetylcholine release. • The effects of binding at α2 receptors are mediated by inhibition of adenylyl cyclase and a fall in the levels of intracellular c-AM ...
Depression
Depression

... norepinephrine causes an increase in extracellular amine levels. • Phenelzine is a none selective • Moclobemide is a reversible and selective inhibitor of MAO-A • Selegiline is a selective for MAO-B • Side effects: ...
Drugs affecting Neuromuscular Transmission
Drugs affecting Neuromuscular Transmission

... LOW DOSES: drug combines w/nicotinic receptor and prevents the binding of Achinhibiting muscular contraction HI DOSES: block ion channels of end-plate  further weakening of NM transmission and  ability of Achesterase inhibitors to rever the actions of these drugs ...
曹永孝
曹永孝

... contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow gastric emptying and increase symptoms with gastr ...
Chapter 8 Cholinoceptor
Chapter 8 Cholinoceptor

... contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow gastric emptying and increase symptoms with gastr ...
No Slide Title
No Slide Title

... • Pain in absence or in addition to nociceptive component • Example – trigeminal neuralgia • Characteristics of pain ...
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NK1 receptor antagonist

Neurokinin 1 (NK1) antagonists are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy.An example of a drug in this class is aprepitant. Chemotherapy-induced emesis appears to consist of acute and delayed phases. So far, the acute phase emesis responds to 5-HT3 antagonists while the delayed phase remains difficult to control. The discovery and development of NK1 receptor antagonists have elicited antiemetic effect in both acute and especially in delayed phases of emesis.The first registered clinical use of NK1 receptor antagonists was the treatment of emesis, associated with cancer chemotherapy.
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