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Bioinorganic Chemistry Glossar
Bioinorganic Chemistry Glossar

... pyrrolerings (17-18) has been reduced. A fused cyclopentanone ring is also present. Cisplatin: Cis-diamminedichloroplatinum(II), antitumor drug. Of major importance in the antitumoractivity of this drug is its interaction with the nucleic acid bases of DNA. Cluster: Metal centers grouped close toget ...
G-protein linked receptors
G-protein linked receptors

... their effects through G-protein linked receptors. ...
Hidden Names for MSG - Battling the MSG Myth
Hidden Names for MSG - Battling the MSG Myth

... Fructose (from corn) Spice Lipolyzed butter fat Brown rice syrup Gums (guar, vegetable, xanthan) Corn syrup solids ...
Second Messengers & Protein Kinases
Second Messengers & Protein Kinases

... 1. Protein kinases, e.g. PKA - A ser, thr kinase ...
A Crash Course on Enzymology
A Crash Course on Enzymology

... unaffected. What could be a cause why Todd is affected but Kevin isn’t? ...
Part I ()
Part I ()

... First flash-cooling of a protein crystal (1982) Discovery of first ligand path through a protein (1984) First measurement of thermal expansion of a protein (1987) Invention of fragment-based drug discovery (1992) Mechanism of iron-dependent control of transcription (1995) Structures and mechanisms o ...
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File

... Background: Lactate dehydrogenase (LDH), an enzyme is found in cells from nearly all organisms, catalyzes the interconversion of lactate and pyruvate. Although this protein has a highly conserved sequence, it is known to have several non-conserved amino acids that vary between species. Research has ...
Chapter 8. Muscle molecular mechanism in strength training
Chapter 8. Muscle molecular mechanism in strength training

... – Relatively short exposure is sufficient in animal studies ...
bioinformatics lec10student
bioinformatics lec10student

... according to the size Fewer than 50 aa called peptide More than 50 is called protein Insulin is 53 aa long Is it a peptide or protein hormone? ...
Arabidopsis thaliana proteins involved in signalling pathways
Arabidopsis thaliana proteins involved in signalling pathways

... exclusion chromatography. The homogenous protein was submitted for crystallization. X-Ray diffraction data extending to 1.9Å resolution were collected using synchrotron radiation. The structure was solved by molecular replacement using Pyrococcus furiosus structure coordinates (PDB code: 1twl) havin ...
The complex formation between polyacrylamide containing glycine
The complex formation between polyacrylamide containing glycine

... struction of artificial polymer-subunit antigens and synthetic vaccines [1, 4-@ This method consists of the use of small concentrations of transient metal ions which promote the PE binding to the protein without causing any appreciable changes in the chemical structure of PE and, correspondingly, it ...
The ubiquitin-proteasome system and its role in the cell
The ubiquitin-proteasome system and its role in the cell

... Nobel prize in chemistry, 2004 ...
High Nucleotide Yeast Specification
High Nucleotide Yeast Specification

... ß-glucans and ß-mannans. It is high in free nucleotides which are essential building blocks for cell regeneration and replication. These free nucleotides are most important for young animals which have yet to develop endogenous enzyme systems to release free nucleotides from dietary materials. They ...
S21 Table. Function of genes showing significant associations
S21 Table. Function of genes showing significant associations

... Belongs to the system L family of plasma membrane carrier proteins that transport large neutral amino acids (3). Sterol regulatory element binding transcription factor 1 Encodes a transcription factor binding to the sterol regulatory element-1, which is a decamer flanking the low density lipoprotein ...
PIRSF is a protein classification system based on the evolutionary
PIRSF is a protein classification system based on the evolutionary

... PIRSF is a protein classification system based on the evolutionary relationships of whole proteins, whereby family members are both homologous (sharing common ancestry) and homeomorphic (sharing full-length sequence similarity with common domain architecture). The system adopts a network structure f ...
< 1 2 3 4

Protein C



Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease as it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.The zymogenic form of protein C is a vitamin K-dependent glycoprotein that circulates in blood plasma. Its structure is that of a two-chain polypeptide consisting of a light chain and a heavy chain connected by a disulfide bond. The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). Because of EPCR's role, activated protein C is found primarily near endothelial cells (i.e., those that make up the walls of blood vessels), and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis).Research into the clinical use of activated protein C also known as drotrecogin alfa-activated (branded Xigris) has been surrounded by controversy. The manufacturer Eli Lilly and Company ran an aggressive marketing campaign to promote its use in people with severe sepsis and septic shock including the sponsoring of the 2004Surviving Sepsis Campaign Guidelines. A 2011 Cochrane review however found that its use cannot be recommended as it does not improve survival (and increases bleeding risk).
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