Liquid loaded microneedles for the intradermal delivery of
... and Dr James Birchall for their supportive guidance, advice and enthusiasm throughout the course of this research project. Special thanks go to Dr Sion Coulman for critically reviewing my Thesis. Without his precious help this Thesis would not have been written. I extend my gratitude to Cardiff Univ ...
... and Dr James Birchall for their supportive guidance, advice and enthusiasm throughout the course of this research project. Special thanks go to Dr Sion Coulman for critically reviewing my Thesis. Without his precious help this Thesis would not have been written. I extend my gratitude to Cardiff Univ ...
- Surrey Research Insight Open Access
... C. tetani is the causative agent of tetanus; a disease which has been documented throughout history with records dating back to early Greek physicians over 2000 years ago (Humeau et al, 2000). The characteristics of the disease are very recognisable; severe and debilitating spastic paralysis as a re ...
... C. tetani is the causative agent of tetanus; a disease which has been documented throughout history with records dating back to early Greek physicians over 2000 years ago (Humeau et al, 2000). The characteristics of the disease are very recognisable; severe and debilitating spastic paralysis as a re ...
Understanding your BOTOX treatment Answers to questions about BOTOX
... hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing There has not been a confirmed serious case of spread of toxin effect away from the injection site when BOTOX® has been used at the recommended ...
... hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing There has not been a confirmed serious case of spread of toxin effect away from the injection site when BOTOX® has been used at the recommended ...
Novel Approaches to the Treatment of Systemic Anthrax
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
BACILLUS SPHAERICUS TOXINS: Molecular Biology and Mode of
... differences in amino acid sequences of P51 are 5 and 3 amino acids, respectively and those for P42 are 1 and 5. these variations appear to be responsible for the differences in specificity of these strains (see below). Interestingly, LPI-G is only weakly active , although it produces the crystal tox ...
... differences in amino acid sequences of P51 are 5 and 3 amino acids, respectively and those for P42 are 1 and 5. these variations appear to be responsible for the differences in specificity of these strains (see below). Interestingly, LPI-G is only weakly active , although it produces the crystal tox ...
The Truth About Botox
... actually relaxes muscles when it is injected directly into them. It has no ability to cause effects beyond a few millimeters where it is injected. This drug is only manufactured by a company called Allergan. We only use this form of the drug and will never use any medications that have not been appr ...
... actually relaxes muscles when it is injected directly into them. It has no ability to cause effects beyond a few millimeters where it is injected. This drug is only manufactured by a company called Allergan. We only use this form of the drug and will never use any medications that have not been appr ...
What is Tetanus?
... INCIDENCE OF TETANUS Decreased prevalence in industrialized nations Tetanus is rare in the U.S. due to immunizations and improved wound care ...
... INCIDENCE OF TETANUS Decreased prevalence in industrialized nations Tetanus is rare in the U.S. due to immunizations and improved wound care ...
Botulinum Toxin in the Treatment of Chronic Pain and Headaches
... Clinical experience suggest that migraineurs are most-responsive to medications within the initial 30-60 minutes of an attack. The development of central hypersensitivity points to the need for the early use of antimigraine drugs. ...
... Clinical experience suggest that migraineurs are most-responsive to medications within the initial 30-60 minutes of an attack. The development of central hypersensitivity points to the need for the early use of antimigraine drugs. ...
S3 File.
... Behind ET, IPD is the second most common cause of tremor. BoNT A therapy has been investigated for treatment of tremor in this population as well as in ET. While tremor is a benign symptom of IPD, it is frequently targeted for treatment as it often leads to social anxiety and inconvenience in daily ...
... Behind ET, IPD is the second most common cause of tremor. BoNT A therapy has been investigated for treatment of tremor in this population as well as in ET. While tremor is a benign symptom of IPD, it is frequently targeted for treatment as it often leads to social anxiety and inconvenience in daily ...
Characterization of diffusion and duration of action of a
... Cheng et al., 2006a,b). It has also been used clinically in aesthetics for cosmetic treatment of frown lines and wrinkles to improve facial appearance (Lowe, 2007; Flynn, 2007; Klein et al., 2008). However, the application of BoNTA in clinical use has been limited by side effects resulting ...
... Cheng et al., 2006a,b). It has also been used clinically in aesthetics for cosmetic treatment of frown lines and wrinkles to improve facial appearance (Lowe, 2007; Flynn, 2007; Klein et al., 2008). However, the application of BoNTA in clinical use has been limited by side effects resulting ...
One cannot rule them all: Are bacterial toxins
... showed that the funds devoted to this area are small and clearly insufficient (Head et al., 2014). Furthermore, most large pharmaceutical companies have stopped investing in new antibiotic research and development: the number of industries working on active discovery and development programs for ant ...
... showed that the funds devoted to this area are small and clearly insufficient (Head et al., 2014). Furthermore, most large pharmaceutical companies have stopped investing in new antibiotic research and development: the number of industries working on active discovery and development programs for ant ...
Clostridium difficile-Associated Diarrhea
... AAD is usually moderate in severity. Less severe diarrhea may be treated symptomatically paying particular attention to hydration status.1 More severe diarrhea may require discontinuation of the offending antibiotic. Diarrhea usually resolves upon antibiotic discontinuation.2 If antibiotic therapy i ...
... AAD is usually moderate in severity. Less severe diarrhea may be treated symptomatically paying particular attention to hydration status.1 More severe diarrhea may require discontinuation of the offending antibiotic. Diarrhea usually resolves upon antibiotic discontinuation.2 If antibiotic therapy i ...
BOTOX COSMETIC
... Pregnant Women: There are no adequate and well-controlled studies of BOTOX COSMETIC® administration in pregnant women. Studies in animals have shown reproductive toxicity. The potential risk for humans is unknown. BOTOX COSMETIC® should not be used during pregnancy. If this drug is used during pregn ...
... Pregnant Women: There are no adequate and well-controlled studies of BOTOX COSMETIC® administration in pregnant women. Studies in animals have shown reproductive toxicity. The potential risk for humans is unknown. BOTOX COSMETIC® should not be used during pregnancy. If this drug is used during pregn ...
FROM THE MAR DEL PLATA COAST (ARGENTINA)
... lower levels occurred in the foot and mucous secretion (Table 2). Toxin composition of the different species anaIyzed were similar to each other, with STX as the main component (87 - 99%) and only trace amounts of neoSTX, dcSTX, GTX2 and GTX3 (Table 1). In relation to the viscera, the foot and the m ...
... lower levels occurred in the foot and mucous secretion (Table 2). Toxin composition of the different species anaIyzed were similar to each other, with STX as the main component (87 - 99%) and only trace amounts of neoSTX, dcSTX, GTX2 and GTX3 (Table 1). In relation to the viscera, the foot and the m ...
Document
... mother is not immune. Usually occurs through infection of the unhealed umbilical stump, particularly when the stump is cut with an unsterile ...
... mother is not immune. Usually occurs through infection of the unhealed umbilical stump, particularly when the stump is cut with an unsterile ...
BOTULINUM TOXINS A AND B
... There are seven serologically distinct forms of botulinum toxin, A through G. All seven neurotoxins share a common structure consisting of one heavy chain and one light chain. They all inhibit acetylcholine release at the neuromuscular junction via the enzymatic inactivation of a protein that is req ...
... There are seven serologically distinct forms of botulinum toxin, A through G. All seven neurotoxins share a common structure consisting of one heavy chain and one light chain. They all inhibit acetylcholine release at the neuromuscular junction via the enzymatic inactivation of a protein that is req ...
Botulinum Toxins A and B - UnitedHealthcareOnline.com
... group ASO plans, are not subject to the requirement to offer coverage for EHBs. However, if such plans choose to provide coverage for benefits which are deemed EHBs, the ACA requires all dollar limits on those benefits to be removed on all Grandfathered and Non-Grandfathered plans. The determinatio ...
... group ASO plans, are not subject to the requirement to offer coverage for EHBs. However, if such plans choose to provide coverage for benefits which are deemed EHBs, the ACA requires all dollar limits on those benefits to be removed on all Grandfathered and Non-Grandfathered plans. The determinatio ...
Spasticity - Utah Physical Therapy Association
... BTX-A is currently used for children of all ages with CP for spasticity management as determined by the practitioner This use is off-label in the US Dysport (British formulation), approved in UK and EU for “treatment of dynamic equinus foot deformity due to spasticity in ambulant pediatric CP pa ...
... BTX-A is currently used for children of all ages with CP for spasticity management as determined by the practitioner This use is off-label in the US Dysport (British formulation), approved in UK and EU for “treatment of dynamic equinus foot deformity due to spasticity in ambulant pediatric CP pa ...
Treatment of Hyperhidrosis with Botulinum Toxin A
... but functionally cholinergic fibers. The neurotransmitter involved is therefore acetylcholine. The diagnosis of primary focal hyperhidrosis can usually readily be made based upon the patient’s history of wet armpits and massive sweating of the palms and soles after emotional stress. Causes of second ...
... but functionally cholinergic fibers. The neurotransmitter involved is therefore acetylcholine. The diagnosis of primary focal hyperhidrosis can usually readily be made based upon the patient’s history of wet armpits and massive sweating of the palms and soles after emotional stress. Causes of second ...
HOW TO SELECT MIGRAINE HOW TO SELECT MIGRAINE PREVENTIVES Financial Disclosure
... Refractory migraine or transformed migraine Antagonist at NMDA receptors, blocks excessive activity but not normal function 28 patients, 3 months, not placebo controlled Endpoints: days with headache reduced(22‐>16), d ith days with severe pain reduced (7.8 ‐>3.2), less i d d ( 8 ...
... Refractory migraine or transformed migraine Antagonist at NMDA receptors, blocks excessive activity but not normal function 28 patients, 3 months, not placebo controlled Endpoints: days with headache reduced(22‐>16), d ith days with severe pain reduced (7.8 ‐>3.2), less i d d ( 8 ...
Prescribing Information including Medication Guide
... Reconstituted XEOMIN is intended for intramuscular injection only. If proposed injection sites are marked with a pen, the product must not be injected through the pen marks; otherwise a permanent tattooing effect may occur. The number of injection sites is dependent upon the size of the muscle to be ...
... Reconstituted XEOMIN is intended for intramuscular injection only. If proposed injection sites are marked with a pen, the product must not be injected through the pen marks; otherwise a permanent tattooing effect may occur. The number of injection sites is dependent upon the size of the muscle to be ...
Hagyard Veterinarians Identify Toxin Associated With Clostridium
... identification of the NetF toxin in foals in Kentucky. (This toxin is found in other parts of the world as well.) Normally, Clostridium species, including C. perfringens, are present within the gastrointestinal tract in low numbers and do not cause disease. However, under certain conditions, horses ...
... identification of the NetF toxin in foals in Kentucky. (This toxin is found in other parts of the world as well.) Normally, Clostridium species, including C. perfringens, are present within the gastrointestinal tract in low numbers and do not cause disease. However, under certain conditions, horses ...
Toxic shock syndrome toxin-1 from Staphylococcus aureus Product
... TSST-1 is a toxin secreted by Staphylococcus aureus in response to environmental stress, such as low oxygen or low nutrient content in its surroundings. The protein is highly resistant to proteases and is stable from pH 2.5-11 and at temperatures exceeding 60 °C. In its active form, TSST-1 contains ...
... TSST-1 is a toxin secreted by Staphylococcus aureus in response to environmental stress, such as low oxygen or low nutrient content in its surroundings. The protein is highly resistant to proteases and is stable from pH 2.5-11 and at temperatures exceeding 60 °C. In its active form, TSST-1 contains ...
„Approved”
... some of these cases, C botulinum organisms, but no preformed toxin, could be found in foods the patients had ingested. These cases were associated with a prolonged latent period of up to 47 days postingestion before onset of symptoms. In one study, 2 of 4 patients had surgical alterations of the gas ...
... some of these cases, C botulinum organisms, but no preformed toxin, could be found in foods the patients had ingested. These cases were associated with a prolonged latent period of up to 47 days postingestion before onset of symptoms. In one study, 2 of 4 patients had surgical alterations of the gas ...
Botulinum toxin
Botulinum toxin (BTX) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It is also produced commercially for medical, cosmetic, and research use. There are two main commercial types: botulinum toxin type A and botulinum toxin type B.Infection with the bacterium may result in a potentially fatal disease called botulism. Botulinum is the most acutely lethal toxin known, with an estimated human median lethal dose (LD50) of 1.3–2.1 ng/kg intravenously or intramuscularly and 10–13 ng/kg when inhaled.Botulinum toxin type A and B is used in medicine for, among others, upper motor neuron syndrome, focal hyperhidrosis, blepharospasm, strabismus, chronic migraine and bruxism. It is also widely used in cosmetic treatments. The U.S. Food and Drug Administration requires a boxed warning stating that when locally administered the toxin may spread from the injection site to other areas of the body, causing symptoms similar to those of botulism. The warning was the result of deaths associated with its uses. The commercial form is marketed under the brand name Botox, among others.