ricinus communis l - doc-developpement
... mast cells in mice. 24 Antifertility activity:- The present findings indicate that the ether soluble portion of the methanol extract of Ricinus communis var. minor possesses anti-implantation, anticonceptive and estrogenic activity in rats and mice when administered subcutaneously. This is supported ...
... mast cells in mice. 24 Antifertility activity:- The present findings indicate that the ether soluble portion of the methanol extract of Ricinus communis var. minor possesses anti-implantation, anticonceptive and estrogenic activity in rats and mice when administered subcutaneously. This is supported ...
Endoplasmic Reticulum-Associated Degradation of Ricin A Chain
... A chain to investigate whether the presence of internal Lys residues that could act as attachment sites for polyubiquitin chains is required for the transport and/or degradation of an ERAD substrate in plant cells. Ricin is a heterodimeric ribosome-inactivating protein that accumulates in castor bea ...
... A chain to investigate whether the presence of internal Lys residues that could act as attachment sites for polyubiquitin chains is required for the transport and/or degradation of an ERAD substrate in plant cells. Ricin is a heterodimeric ribosome-inactivating protein that accumulates in castor bea ...
RIBOSOME-INACTIVATING PROTEINS: A Plant Perspective
... depending on both the RIP and the particular tRNA. Tritin-S was fairly nonspecific in being stimulated equally by different tRNAs, whereas gelonin was stimulated only by tRNATrp from mammalian and avian cells and not by other tRNAs or tRNATrp from yeast (20–23). Given the variety of assays and assay ...
... depending on both the RIP and the particular tRNA. Tritin-S was fairly nonspecific in being stimulated equally by different tRNAs, whereas gelonin was stimulated only by tRNATrp from mammalian and avian cells and not by other tRNAs or tRNATrp from yeast (20–23). Given the variety of assays and assay ...
THE PLANT LECTINS
... University of Oklahoma Health Sciences Center College of Medicine Oklahoma Center for Medical Glycobiology ...
... University of Oklahoma Health Sciences Center College of Medicine Oklahoma Center for Medical Glycobiology ...
Disulfide formation in plant storage vacuoles permits assembly
... In vivo radiolabelling of Ricinus communis endosperm tissue Ricinus communis plants were grown from dry seeds in an equal mix of multi-purpose compost and vermiculite under greenhouse conditions at 15°C with a 16 hour light / 8 hour dark cycle. Prior to planting, seeds were imbibed in running water ...
... In vivo radiolabelling of Ricinus communis endosperm tissue Ricinus communis plants were grown from dry seeds in an equal mix of multi-purpose compost and vermiculite under greenhouse conditions at 15°C with a 16 hour light / 8 hour dark cycle. Prior to planting, seeds were imbibed in running water ...
Evidence that the transport of ricin to the cytoplasm is independent
... Golgi, they are returned to the ER via COPI-coated vesicles. A major insight into the retrograde transport of protein toxins was that some toxins, such as cholera toxin, contain the KDEL sequence that allows them to be transported in COPI-coated vesicles from the Golgi to the ER (Lencer et al., 1995 ...
... Golgi, they are returned to the ER via COPI-coated vesicles. A major insight into the retrograde transport of protein toxins was that some toxins, such as cholera toxin, contain the KDEL sequence that allows them to be transported in COPI-coated vesicles from the Golgi to the ER (Lencer et al., 1995 ...
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... In order to increase the selectivity and sensitivity of the peptide analysis described above, tandem mass spectrometry has been used in targeted approaches for the detection of specific peptides. The operation of triple quadrupole or ion trap mass spectrometers to monitor specific transitions after ...
... In order to increase the selectivity and sensitivity of the peptide analysis described above, tandem mass spectrometry has been used in targeted approaches for the detection of specific peptides. The operation of triple quadrupole or ion trap mass spectrometers to monitor specific transitions after ...
Calcium regulates ricin transport to the Golgi apparatus
... LY294002, suggesting that phosphoinositide 3-kinase might be involved in transport of ricin to the Golgi apparatus. Together, these findings indicate that the different pathways to the Golgi apparatus utilized by ricin and the mannose 6-phosphate receptor are regulated by different mechanisms. ...
... LY294002, suggesting that phosphoinositide 3-kinase might be involved in transport of ricin to the Golgi apparatus. Together, these findings indicate that the different pathways to the Golgi apparatus utilized by ricin and the mannose 6-phosphate receptor are regulated by different mechanisms. ...
PP04 - ISpatula
... 22- Syrup of ipecac does not have a highly rate of success, produce efficient emesis, has short latency and has no dangerous side effects. 23- If RCA is injected into the blood, it will cause the red blood cells to agglutinate and burst by hemolysis. 24- The entire foxglove plant is toxic. Symptoms ...
... 22- Syrup of ipecac does not have a highly rate of success, produce efficient emesis, has short latency and has no dangerous side effects. 23- If RCA is injected into the blood, it will cause the red blood cells to agglutinate and burst by hemolysis. 24- The entire foxglove plant is toxic. Symptoms ...
The enemy within: ricin and plant cells
... Ricin, a ribosome-inactivating protein from the seeds of the castor oil plant (Ricinus communis L.) is one of the most potent cell poisons known. It is able to bind and enter most mammalian cells where it exploits their fully reversible secretory pathway to reach the endoplasmic reticulum. Ricin is ...
... Ricin, a ribosome-inactivating protein from the seeds of the castor oil plant (Ricinus communis L.) is one of the most potent cell poisons known. It is able to bind and enter most mammalian cells where it exploits their fully reversible secretory pathway to reach the endoplasmic reticulum. Ricin is ...
Medicines, Drugs and Poisons
... Cocaine produces a shortlived euphoric feeling due to the stimulation of the central nervous system • chewed by Andean natives • cocaine in leaves low • purified cocaine is highly addictive ...
... Cocaine produces a shortlived euphoric feeling due to the stimulation of the central nervous system • chewed by Andean natives • cocaine in leaves low • purified cocaine is highly addictive ...
Ricin Fact Sheet
... Chemical Weapons Convention (CWC), and is a Category B substance under the Biological and Toxins Weapons Convention (BTWC). Ricin has attracted interest as a military chemical/biological warfare agent and as a poison for criminal and terrorist ...
... Chemical Weapons Convention (CWC), and is a Category B substance under the Biological and Toxins Weapons Convention (BTWC). Ricin has attracted interest as a military chemical/biological warfare agent and as a poison for criminal and terrorist ...
Scientists Complete Genome Sequence of Castor Bean Beans also
... the source of the highly valuable castor oil, and their findings will be published in the September issue of Nature Biotechnology (published online on 8/22/10). Castor bean also produces the highly toxic protein ricin, which has been reportedly used for bioterror threats. The availability of the cas ...
... the source of the highly valuable castor oil, and their findings will be published in the September issue of Nature Biotechnology (published online on 8/22/10). Castor bean also produces the highly toxic protein ricin, which has been reportedly used for bioterror threats. The availability of the cas ...
Julie Little Virginia Highlands Community College Ricin
... Goal: At VHCC, we cover the immune system at the very end of the second semester. By then, most students have forgotten many important details covered in beginning of the first semester (ex. Cell Biology). After lecturing on the immune system, I will describe Dr. Seth Pincus’ research showing how ri ...
... Goal: At VHCC, we cover the immune system at the very end of the second semester. By then, most students have forgotten many important details covered in beginning of the first semester (ex. Cell Biology). After lecturing on the immune system, I will describe Dr. Seth Pincus’ research showing how ri ...
Extraction, Purification and Analysis of Anti cancer activity of Ricin
... Ricin, one of the well known plant toxins has played a vital role in the history of medicine. It is usually extracted from Ricinus Communis, a common plant. The use of these proteins in medical treatment since ancient times is reviewed. Later the proteins played important roles in the early days of ...
... Ricin, one of the well known plant toxins has played a vital role in the history of medicine. It is usually extracted from Ricinus Communis, a common plant. The use of these proteins in medical treatment since ancient times is reviewed. Later the proteins played important roles in the early days of ...
Ricin_Straight_Tox
... There are many non-medical uses of castor oil as well. In the United States, castor oil has been used in aircraft lubricants, hydraulic fluids, synthesis of soaps, linoleum, printer’s ink, nylon, varnishes, and in the manufacture of explosives. The seeds, stems and leaves of the castor bean plant al ...
... There are many non-medical uses of castor oil as well. In the United States, castor oil has been used in aircraft lubricants, hydraulic fluids, synthesis of soaps, linoleum, printer’s ink, nylon, varnishes, and in the manufacture of explosives. The seeds, stems and leaves of the castor bean plant al ...
(A) and B chains - Michael P. Ready
... RIP (ricin-A, ricin-B, and lectin RCAA and RCA-B from castor bean; abrin-A, abrina/b-B, and agglutinin APA-A and APA-B from A. precatorius; SNAI-A and SNAI-B, SNAV-A and SNAV-B, SNAI'-A and SNAI'-B, LRPSN1-A and LRPSN1-B, LRPSN2-A and LRPSN2-B, and SNAIV from S. nigra; sieboldinb-A, sieboldinb-B, SS ...
... RIP (ricin-A, ricin-B, and lectin RCAA and RCA-B from castor bean; abrin-A, abrina/b-B, and agglutinin APA-A and APA-B from A. precatorius; SNAI-A and SNAI-B, SNAV-A and SNAV-B, SNAI'-A and SNAI'-B, LRPSN1-A and LRPSN1-B, LRPSN2-A and LRPSN2-B, and SNAIV from S. nigra; sieboldinb-A, sieboldinb-B, SS ...
Ricin
Ricin /ˈraɪsɪn/ is a highly toxic, naturally occurring lectin (a carbohydrate-binding protein) produced in the seeds of the castor oil plant, Ricinus communis. A dose of purified ricin powder the size of a few grains of table salt can kill an adult human. The median lethal dose (LD50) of ricin is around 22 micrograms per kilogram of body weight if the exposure is from injection or inhalation (1.78 milligram for an average adult). For comparison, a standard paracetamol (acetaminophen) tablet contains 500 mg of acetaminophen and a low dose aspirin contains 81 mg of aspirin. Oral exposure to ricin is far less toxic, and an estimated lethal dose in humans is approximately 1 milligram per kilogram.