Alzheimer-like neurodegeneration in aged antinerve growth factor
... for the microtubule-associated protein with the phosphorylation-independent mAb ALZ50 (27) and the phosphorylationdependent mAbs AT8 (28) and PHF-1 (29) demonstrated greatly increased labeling of neuronal and glial cells in the cortex and hippocampus of anti-NGF mice (Fig. 3 a, c, e) with respect ...
... for the microtubule-associated protein with the phosphorylation-independent mAb ALZ50 (27) and the phosphorylationdependent mAbs AT8 (28) and PHF-1 (29) demonstrated greatly increased labeling of neuronal and glial cells in the cortex and hippocampus of anti-NGF mice (Fig. 3 a, c, e) with respect ...
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... Fig 1. Neurotrophins bind selectively to specific Trk receptors, whereas all neurotrophins bind to p75. Neurotrophin binding to the p75 receptor mediates survival, cell migration and myelination through several signalling pathways. Interactions between Trk and p75 receptors can lead to changes in th ...
... Fig 1. Neurotrophins bind selectively to specific Trk receptors, whereas all neurotrophins bind to p75. Neurotrophin binding to the p75 receptor mediates survival, cell migration and myelination through several signalling pathways. Interactions between Trk and p75 receptors can lead to changes in th ...
Neuronal Growth Cone Retraction Relies Upon Proneurotrophin
... axons is influenced by neurotrophins (7, 8). Neurotrophins, which include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and NT-4, are required for neuronal survival and differentiation, synapse formation, and synaptic plasticity (9). These secreted protein ...
... axons is influenced by neurotrophins (7, 8). Neurotrophins, which include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and NT-4, are required for neuronal survival and differentiation, synapse formation, and synaptic plasticity (9). These secreted protein ...
Musings on the Wanderer: What`s New in Our Understanding of
... that the vagal afferents have much greater regenerating capability compared with the efferent fibers. Plasticity of the nodose ganglia neurons after axotomy. It is well established that primary sensory neurons demonstrate an extraordinary plasticity in their messenger molecule expression when challe ...
... that the vagal afferents have much greater regenerating capability compared with the efferent fibers. Plasticity of the nodose ganglia neurons after axotomy. It is well established that primary sensory neurons demonstrate an extraordinary plasticity in their messenger molecule expression when challe ...
Analysis of p75NTR-dependent apoptotic
... neurotrophins, as shown in a number of gain and loss of function studies. For instance, ectopic expression of Trk receptors confers neurotrophin-dependent survival and differentiation in many neurons (Allsopp et al., 1993; Barrett and Bartlett, 1994). The physiological importance of the Trks in neur ...
... neurotrophins, as shown in a number of gain and loss of function studies. For instance, ectopic expression of Trk receptors confers neurotrophin-dependent survival and differentiation in many neurons (Allsopp et al., 1993; Barrett and Bartlett, 1994). The physiological importance of the Trks in neur ...
Are there differences between the secretion characteristics of NGF
... been demonstrated for neurotrophin-mediated neurotrophin secretion occurring as a consequence of Trk receptor activation (Canossa et al., 1997). However, discordant results have been reported for high potassium-mediated secretion of BDNF from virus-transduced primary cultures of hippocampal neurons ...
... been demonstrated for neurotrophin-mediated neurotrophin secretion occurring as a consequence of Trk receptor activation (Canossa et al., 1997). However, discordant results have been reported for high potassium-mediated secretion of BDNF from virus-transduced primary cultures of hippocampal neurons ...
More Than Just an OFF-Switch: The Essential Role of
... growth factor of the central nervous system, is a member of the family of neurotrophins, which also comprises nerve growth factor (NGF) and neurotrophins (NT) 3 and 4. Neurotrophins bind to their cognate Trk receptor tyrosine kinases TrkA, B or C, to initiate downstream signaling events (Figure 1) ( ...
... growth factor of the central nervous system, is a member of the family of neurotrophins, which also comprises nerve growth factor (NGF) and neurotrophins (NT) 3 and 4. Neurotrophins bind to their cognate Trk receptor tyrosine kinases TrkA, B or C, to initiate downstream signaling events (Figure 1) ( ...
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... sustained independently of neurotrophins and is downregulated by BDNF. With the acquisition of NGF dependence, p75 and trkA mRNA levels increase markedly in vivo. At this stage in vitro, the level of p75 mRNA is upregulated by NGF, but this response is lost at later stages. ...
... sustained independently of neurotrophins and is downregulated by BDNF. With the acquisition of NGF dependence, p75 and trkA mRNA levels increase markedly in vivo. At this stage in vitro, the level of p75 mRNA is upregulated by NGF, but this response is lost at later stages. ...
brain derived neurotrophic factor transport and physiological
... differentiation. The precursor forms of neurotrophins (proneurotrophins) are the dominant form of gene products in animals, which are cleaved to generate prodomain and mature neurotrophins, and are sorted to constitutive or regulated secretory pathway and released. Brain-derived neurotrophic factor ...
... differentiation. The precursor forms of neurotrophins (proneurotrophins) are the dominant form of gene products in animals, which are cleaved to generate prodomain and mature neurotrophins, and are sorted to constitutive or regulated secretory pathway and released. Brain-derived neurotrophic factor ...
Spatially and Functionally Distinct Roles of the PI3
... nervous system, sympathetic neurons and cutaneous sensory neurons are dependent upon target-derived NGF for survival during development, while in the central nervous system, NGF is required for growth of cholinergic neurons whose cell bodies are located in the basal forebrain. The diverse biological ...
... nervous system, sympathetic neurons and cutaneous sensory neurons are dependent upon target-derived NGF for survival during development, while in the central nervous system, NGF is required for growth of cholinergic neurons whose cell bodies are located in the basal forebrain. The diverse biological ...
Neurogenesis in Postnatal Mouse Dorsal Root Ganglia
... All rights of reproduction in any form reserved. ...
... All rights of reproduction in any form reserved. ...
Regulation of neuronal survival and death by extracellular signals
... above, some neurons have more complex and changing requirements for retrograde trophic support during development. The ®rst and best documented example of neurons that switch their survival requirements from one neurotrophic factor to another during development comes from the neurons of the mouse tr ...
... above, some neurons have more complex and changing requirements for retrograde trophic support during development. The ®rst and best documented example of neurons that switch their survival requirements from one neurotrophic factor to another during development comes from the neurons of the mouse tr ...
Expression of the Activating Transcription Factor 3 Prevents c
... Activating transcription factor 3 (ATF3) is induced and functions both as a cellular response to stress and to stimulate proliferation in multiple tissues. However, in the nervous system ATF3 is expressed only in injured neurons. Here we reveal a function of ATF3 in neurons under death stress. Overe ...
... Activating transcription factor 3 (ATF3) is induced and functions both as a cellular response to stress and to stimulate proliferation in multiple tissues. However, in the nervous system ATF3 is expressed only in injured neurons. Here we reveal a function of ATF3 in neurons under death stress. Overe ...
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... 1994). In aged rats, intraventricular infusions of NGF reverse cholinergic neuronal atrophy in the basal forebrain and the concomitant memory impairment (Fischer et al., 1987; 1991; Markowska et al., 1994; MartinezSerrano et al., 1995; 1996; Backman et al., 1996; Castel-Barthe et al., 1996), suggest ...
... 1994). In aged rats, intraventricular infusions of NGF reverse cholinergic neuronal atrophy in the basal forebrain and the concomitant memory impairment (Fischer et al., 1987; 1991; Markowska et al., 1994; MartinezSerrano et al., 1995; 1996; Backman et al., 1996; Castel-Barthe et al., 1996), suggest ...
161021 NGF revised Manuscript with figs
... (but statistically significant) increase in protection. Nine overlapping peptides were identified that ...
... (but statistically significant) increase in protection. Nine overlapping peptides were identified that ...
MOLECULAR AND CELLULAR BIOLOGY
... and stabilize microtubules. However, evidence now indicates that tau may also play a critical role in signaling pathways linked to neuronal development and neurodegeneration. The tau association with numerous signaling proteins such as tyrosine kinases, adaptor proteins, and scaffold proteins suppor ...
... and stabilize microtubules. However, evidence now indicates that tau may also play a critical role in signaling pathways linked to neuronal development and neurodegeneration. The tau association with numerous signaling proteins such as tyrosine kinases, adaptor proteins, and scaffold proteins suppor ...
Sensory Nerves in Adult Rats Regenerate and Restore Sensory
... (mDCN T13) on the left side. Crushing of selected nerves was done with specially ground smooth-jawed forceps at selected regions between the nerve exit point from the body wall and the point of entry into the skin. The forceps were applied to two or three sites about 1 mm apart, for three episodes o ...
... (mDCN T13) on the left side. Crushing of selected nerves was done with specially ground smooth-jawed forceps at selected regions between the nerve exit point from the body wall and the point of entry into the skin. The forceps were applied to two or three sites about 1 mm apart, for three episodes o ...
Involvement of Tumor Necrosis Factor Alpha in Hippocampal
... function. In adult mice, TNFα may interfere with memory consolidation, perhaps by regulating NGF levels. ...
... function. In adult mice, TNFα may interfere with memory consolidation, perhaps by regulating NGF levels. ...
Growth Hormones
... Also recall that thyroid hormone is required for GH synthesis and action: - TRE on GH gene (effects synthesis of GH) - T3 induces GH receptor expression ...
... Also recall that thyroid hormone is required for GH synthesis and action: - TRE on GH gene (effects synthesis of GH) - T3 induces GH receptor expression ...
The Cerebral Cortex and Higher Intellectual Functions
... Brain-derived neurotrophic factor “BDNF” ...
... Brain-derived neurotrophic factor “BDNF” ...
Programmed Cell Death in Neurons
... neurons. ROS are known to function in signaling pathways and regulate gene expression (54). The identification of upstream events and downstream targets of ROS in neurons undergoing PCD will be useful in determining whether the ROS function by regulating gene expression during neuronal death. The re ...
... neurons. ROS are known to function in signaling pathways and regulate gene expression (54). The identification of upstream events and downstream targets of ROS in neurons undergoing PCD will be useful in determining whether the ROS function by regulating gene expression during neuronal death. The re ...
Stem cell factor induces outgrowth of c-kit-positive
... resulted from the survival of DRG neurons induced by rmSCF. Since quantitation of neuronal survival is difficult in organ cultures of DRGs, those from 15.5-day p.c. embryos were dissociated into single cells by trypsinization. These were cultured and the number of surviving neurons was counted. When ...
... resulted from the survival of DRG neurons induced by rmSCF. Since quantitation of neuronal survival is difficult in organ cultures of DRGs, those from 15.5-day p.c. embryos were dissociated into single cells by trypsinization. These were cultured and the number of surviving neurons was counted. When ...
Basal Forebrain Cholinergic System Is Involved in Rapid Nerve
... somatosensory cortex (Prakash et al. 1996b). Our previous histological results suggested that NGF’s site of action is not directly on the neurons within the somatosensory cortex but rather on projections originating outside it. Given that BFCS projection neurons are the only type of neurons with bot ...
... somatosensory cortex (Prakash et al. 1996b). Our previous histological results suggested that NGF’s site of action is not directly on the neurons within the somatosensory cortex but rather on projections originating outside it. Given that BFCS projection neurons are the only type of neurons with bot ...
Phosphorylation of c-Jun in avian and mammalian motoneurons in
... not known whether a similar molecular event is involved in the developmental programmed cell death (PCD) of neurons in vivo.We observed that only a subpopulation of motoneurons (MNs) exhibit c-Jun phosphorylation during the PCD period in chick [embryonic day 5 (E5)-E12] and mouse (E13-E18) embryos. ...
... not known whether a similar molecular event is involved in the developmental programmed cell death (PCD) of neurons in vivo.We observed that only a subpopulation of motoneurons (MNs) exhibit c-Jun phosphorylation during the PCD period in chick [embryonic day 5 (E5)-E12] and mouse (E13-E18) embryos. ...
The Effects of Local Fetal Brain Extract Administration
... capable of regeneration with significant specificity [6]. In this subject, recent experimental studies in adult rodents indicate that neurons of many regions of the brain and spinal cord are capable of extensive axonal growth when implanted into the fetal Central Nervous System (CNS) [7, 8]. Also, i ...
... capable of regeneration with significant specificity [6]. In this subject, recent experimental studies in adult rodents indicate that neurons of many regions of the brain and spinal cord are capable of extensive axonal growth when implanted into the fetal Central Nervous System (CNS) [7, 8]. Also, i ...