Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by
... As depicted in Scheme 4 (top), an unidirectional Ugi-MiB approach can be implemented easily by utilizing the lithocholic acid derivative 17 functionalized with an amino group at C-3. This compound was readily prepared from methyl lithocholate according to reported procedures [13,24]. The 3α-OH is re ...
... As depicted in Scheme 4 (top), an unidirectional Ugi-MiB approach can be implemented easily by utilizing the lithocholic acid derivative 17 functionalized with an amino group at C-3. This compound was readily prepared from methyl lithocholate according to reported procedures [13,24]. The 3α-OH is re ...
Aromatic Compounds
... Substituent Effects in Electrophilic Substitutions Electrostatic potential maps of benzene, phenol (activated), chlorobenzene (weakly deactivated), and benzaldehyde (more strongly deactivated) • The –OH substituent makes the ring more negative (red) • The –Cl makes the ring less negative (orange) • ...
... Substituent Effects in Electrophilic Substitutions Electrostatic potential maps of benzene, phenol (activated), chlorobenzene (weakly deactivated), and benzaldehyde (more strongly deactivated) • The –OH substituent makes the ring more negative (red) • The –Cl makes the ring less negative (orange) • ...
Aromatic electrophilic substitution
... 1. The reaction require a full equivalent of Lewis acid, because the ketone product of the reaction will complex the Lewis acid. 2. The actual electrophilic species is thought to be a bulky complex, such as R-C+=O -AlCl4-. As a result of the size of the electrophile, para substitution is predominat ...
... 1. The reaction require a full equivalent of Lewis acid, because the ketone product of the reaction will complex the Lewis acid. 2. The actual electrophilic species is thought to be a bulky complex, such as R-C+=O -AlCl4-. As a result of the size of the electrophile, para substitution is predominat ...
CH - YSU.edu
... 13. (5 pts) Explain using diagrams why cis-1,3-dimethylcyclohexane is thermodynamically more stable than trans-1,3-dimethylcyclohexane. ...
... 13. (5 pts) Explain using diagrams why cis-1,3-dimethylcyclohexane is thermodynamically more stable than trans-1,3-dimethylcyclohexane. ...
PPT - Gmu
... carbon bearing the leaving group, which departs from back side of molecule. b. A conversion of the molecular configuration occurs. c. Multi-molecular - Reaction depends on the concentration of each of the reactants; thus the reaction is at least second order (sum of exponents in rate equation is >= ...
... carbon bearing the leaving group, which departs from back side of molecule. b. A conversion of the molecular configuration occurs. c. Multi-molecular - Reaction depends on the concentration of each of the reactants; thus the reaction is at least second order (sum of exponents in rate equation is >= ...
ch04 - alkanes
... Immiscible with water and other highly polar solvents Solvent for non -polar organic compounds t The eclipsed conformation has all C-H bonds on adjacent ...
... Immiscible with water and other highly polar solvents Solvent for non -polar organic compounds t The eclipsed conformation has all C-H bonds on adjacent ...
Organic Chemistry I PHS 2025 Fall 2013 Section 1 Lecture Topics
... Stability of Cycloalkanes: Ring Strain Define: Angle Strain ...
... Stability of Cycloalkanes: Ring Strain Define: Angle Strain ...
ethers - WordPress.com
... • Alkoxides prepared by reaction of an alcohol with a strong base such as sodium hydride, NaH ...
... • Alkoxides prepared by reaction of an alcohol with a strong base such as sodium hydride, NaH ...
Fundamentals Of Organic Chemistry
... Similarly, neopentyl alcohol on dehydration by the formation of carbocation gives 2-methylbut-2-ene and 2-methyl-but-1-ene here alkyl shifts occurs in the carbocation. ...
... Similarly, neopentyl alcohol on dehydration by the formation of carbocation gives 2-methylbut-2-ene and 2-methyl-but-1-ene here alkyl shifts occurs in the carbocation. ...
Chapter 16
... Reactive electrophile: resonance-stabilized acyl cation An acyl cation does not rearrange ...
... Reactive electrophile: resonance-stabilized acyl cation An acyl cation does not rearrange ...
Slides from Chapter 4 - FIU Faculty Websites
... conformations. In the anti conformation, the two CH3 groups are on opposite sides of the structure. In the gauche conformations, the two groups are within van der Waals repulsive interaction distance, and 3.8 kJ/mol of steric strain energy is introduced. ...
... conformations. In the anti conformation, the two CH3 groups are on opposite sides of the structure. In the gauche conformations, the two groups are within van der Waals repulsive interaction distance, and 3.8 kJ/mol of steric strain energy is introduced. ...
Electophilic Aromatic Substituion
... Chlorine and iodine (but not fluorine, which is too reactive) ...
... Chlorine and iodine (but not fluorine, which is too reactive) ...
Electophilic Aromatic Substituion
... Chlorine and iodine (but not fluorine, which is too reactive) ...
... Chlorine and iodine (but not fluorine, which is too reactive) ...
Handout
... Can you recognize molecules that have interactions through induced-dipoleinduced-dipole (van der Waals), dipole-dipole and hydrogen bond? Can you compare the b.p. and solubility of molecules based on their structures? ...
... Can you recognize molecules that have interactions through induced-dipoleinduced-dipole (van der Waals), dipole-dipole and hydrogen bond? Can you compare the b.p. and solubility of molecules based on their structures? ...
The characteristic reaction of aromatic rings
... forming an arenium ion è This first step is like an addition to an ordinary double bond è The arenium ion is stabilized by resonance which delocalizes the charge ...
... forming an arenium ion è This first step is like an addition to an ordinary double bond è The arenium ion is stabilized by resonance which delocalizes the charge ...
File - Chemistry Workshop
... A secondary carbon is directly bonded to two other C’s. A tertiary carbon is directly bonded to three other C’s. Multivalent atoms are 1º, 2º, or 3º by bonding to C’s. Univalent atom or group not really 1º, 2º, or 3º on its own - ID depends on type of carbon it is bonded to. ...
... A secondary carbon is directly bonded to two other C’s. A tertiary carbon is directly bonded to three other C’s. Multivalent atoms are 1º, 2º, or 3º by bonding to C’s. Univalent atom or group not really 1º, 2º, or 3º on its own - ID depends on type of carbon it is bonded to. ...
t.h.e_2 - Homework Market
... The following sets of question pertain to intermolecular forces: (a) Provide a valid structure for each of the following molecules and then, arrange the compounds in order of increasing boiling point (you may want to consult the Aldrich catalog, an MSDS, or go to chemfinder.com to find the bps). Bri ...
... The following sets of question pertain to intermolecular forces: (a) Provide a valid structure for each of the following molecules and then, arrange the compounds in order of increasing boiling point (you may want to consult the Aldrich catalog, an MSDS, or go to chemfinder.com to find the bps). Bri ...
Lab 2 - Academic Computer Center
... easy to spot, because they involve two organic reactants and only heat as a reactant. One of the reactants (the diene) must have a conjugated diene system, and the other reactant (the dienophile) must contain a double bond or triple bond. The diene might have EDGs and the dienophile might have EWGs. ...
... easy to spot, because they involve two organic reactants and only heat as a reactant. One of the reactants (the diene) must have a conjugated diene system, and the other reactant (the dienophile) must contain a double bond or triple bond. The diene might have EDGs and the dienophile might have EWGs. ...
Handout 5
... Generally speaking, cyclic alkanes found in nature have five or six-membered rings. On the other hand, compounds with three and four-membered rings are found much less frequently. This observation suggested that alkanes with five- and six-membered rings must be more stable than those with three- or ...
... Generally speaking, cyclic alkanes found in nature have five or six-membered rings. On the other hand, compounds with three and four-membered rings are found much less frequently. This observation suggested that alkanes with five- and six-membered rings must be more stable than those with three- or ...
exam3 answers - Moorpark College
... A. List all the intermolecular forces that need to be overcome for the compound A given below to boil? ...
... A. List all the intermolecular forces that need to be overcome for the compound A given below to boil? ...
Topic Selection Menu - Pennsylvania State University
... • Dynamic conformer changes • Relief of torsional and flagpole strain – Comparison of energy of cyclohexane conformations – Monosubstituted cyclohexanes • Chair, half chair, boat • Ring flips • Comparison of steric effects of different substituents (1,3diaxial interactions) – Calculation and compari ...
... • Dynamic conformer changes • Relief of torsional and flagpole strain – Comparison of energy of cyclohexane conformations – Monosubstituted cyclohexanes • Chair, half chair, boat • Ring flips • Comparison of steric effects of different substituents (1,3diaxial interactions) – Calculation and compari ...
Topic Selection Menu - Pennsylvania State University
... • Dynamic conformer changes • Relief of torsional and flagpole strain – Comparison of energy of cyclohexane conformations – Monosubstituted cyclohexanes • Chair, half chair, boat • Ring flips • Comparison of steric effects of different substituents (1,3diaxial interactions) – Calculation and compari ...
... • Dynamic conformer changes • Relief of torsional and flagpole strain – Comparison of energy of cyclohexane conformations – Monosubstituted cyclohexanes • Chair, half chair, boat • Ring flips • Comparison of steric effects of different substituents (1,3diaxial interactions) – Calculation and compari ...
E30 ENANTIOMERS - CHIRALITY IN ORGANIC CHEMISTRY
... Stereoisomers Definition: Stereoisomers are isomers with the same constitution, but differ in the arrangement of their atoms in space. They may have different physical and chemical properties. Stereoisomers can be defined further into conformers and configurational isomers. Conformational Isomers De ...
... Stereoisomers Definition: Stereoisomers are isomers with the same constitution, but differ in the arrangement of their atoms in space. They may have different physical and chemical properties. Stereoisomers can be defined further into conformers and configurational isomers. Conformational Isomers De ...