Download Blood Component Preparation: From Benchtop to Bedside Brochure

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Blood Component Preparation: From Benchtop to Bedside
Description:
This convenient resource has it all—not only the different methods for blood component preparation but
also the effects that those methods have on the product itself and, thus, the blood recipient. The book
addresses four major areas: overview of methods, additive solutions and containers, frequently used
modifications, and updates on recent technologies and techniques.
Chapters cover:
- Component therapy concepts.
- The platelet-rich plasma, buffy-coat and apheresis methods.
- RBC and platelet additive solutions and containers.
- Leukocyte reduction.
- Component irradiation.
- Components for infants.
- Pathogen reduction technologies.
- Use of automation.
- LEAN manufacturing.
This book will be a useful reference for transfusion service physicians and those in the component
preparation unit alike.
Contents:
Preface
About the Editors
1 Blood Component Therapy from the Beginning
Paul J Schmidt, MD
Background Events
Blood and Politics
Plasma
Civilian Blood and Plasma Banks
Serum for Transfusion
Red Blood Cells
Platelets
Cryoprecipitate
Granulocytes
Yesterday and Tomorrow
References
2 Preparation of Whole-Blood-Derived Platelet
Concentrates
Ralph R Vassallo, MD, FACP
History and Description of Platelet Components from
Whole Blood
Whole Blood Collection Variables and Their Effects on
PRP-PCs Bacterial Contamination of PRP-PCs
Prestorage Pooled PRP-PCs
PRP-PCs vs Apheresis PCs and Buffy-Coat PCs
Nonplatelet Content of PRP-PCs
Conclusion
References
3 The Buffy-Coat Method
Pieter F van der Meer, PhD, and Dirk de Korte, PhD
Blood Bag Systems and Automated Separators
Production of BC-Derived Platelet Concentrates
BC-Reduced Red Cell Concentrates and Plasma
Overnight Hold of Whole Blood
Further Automation of Centrifugation and Separation
Processes
Characteristics of BC-Derived Platelet Concentrates
After Production
Storage of BC-Derived Platelet Concentrates
In-Vivo Evaluation of BC-Derived Platelet Concentrates
Seven-Day Platelet Storage
Summary
References
4 Apheresis Preparation of Blood Components
James W Smith, MD, PhD
Historical Development of Apheresis Preparation of
Blood Components
Rationale for Apheresis Component Preparation
Technologies Involved in Apheresis Component
Preparation
Components Prepared by Apheresis
Adverse Effects on Donors and Recipients
Summary
References
5 Containers and Storage Solutions for Red Blood Cells
John R Hess, MD, MPH, FACP, FAAAS, and
Walter E Kelley, DO
Development of Liquid Red Cell Storage
Red Cell Metabolism
Effects of Storage Solution Ingredients
Compositions of Solutions
How Storage Solutions Work
Plastic Bags
Red Cell Rejuvenation Solutions
Development of Frozen Red Cell Storage
Freeze-Dried Red Cells
References
6 Containers and Additive Solutions for Platelets
Hans Gulliksson, PhD
Historical Background
In-Vitro Platelet Aging at 22 C vs In-Vivo Aging at
37 C
The Use of PAS in Combination with Different Methods
for the Preparation of Platelets for Transfusion
In-Vitro Activation of Platelets During Collection,
Preparation, and Storage at 22 C
Effects on Platelet Metabolism and Function Associated
with Chemical Components in PAS
The Platelet Storage Container
In-Vivo Characteristics of PAS
PAS Options and Alternatives
References
7 White Blood Cell Reduction of Blood Components
Eleftherios C Vamvakas, MD, PhD, MPH
Proven Benefits of WBC Reduction
Process Control of WBC Reduction
Prevention of Transfusion-Related Immunomodulation
Prevention of Transmission of Variant CreutzfeldtJakob Disease Other Possible Benefits of WBC Reduction
Conclusion
References
8 Transfusion-Associated Graft-vs-Host Disease and
Component Manufacture
Jed B Gorlin, MD, MBA
Background
Pathophysiology
Treatment
General Considerations for Irradiation
Indications for Irradiation
Alternatives to Irradiation
References
9 Blood Components for Infants
Ronald G Strauss, MD
Red Blood Cell Transfusions
Platelet Transfusions
Plasma Transfusions
Cryoprecipitated AHF Transfusions
References
10 Pathogen-Inactivation Technologies for Blood
Components
Miguel Lozano, MD, PhD
Technologies for Plasma
Technologies for Platelets
Technologies for Red Blood Cells
Summary
References
11 Automation in Blood Component Preparation Methods
Joan Cid, MD, PhD
First-Generation Automation
Second-Generation Automation Third-Generation Automation
The Future of Automation for Blood Component
Preparation Methods
Conclusion
References
12 Six Sigma and Lean Concepts in the Component
Laboratory
Bobbi Keefe, MT(ASCP), and Michelle Stefan
What Is Lean?
What Is Six Sigma?
Six Sigma and Lean Synergy
Project Teams and Project Management
Lean Six Sigma Tools
Case Study 1: Carter BloodCare’s Component
Processing Laboratory
Case Study 2: Implementation of Automation in a
Component Laboratory
Keys to Success
References
Index
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