Download LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOMED.INSTRUMENTATION SC.
FIRST SEMESTER – NOVEMBER 2009
BI 1811 - ADVANCED MOLECULAR BIOLOGY
Date & Time: 11/11/2009 / 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART-A
Answer ALL questions
(10x 2= 20)
1. What are the special features of CAAT box?
2. Give examples of DNA binding domains.
3. Define the term heterologous recombination.
4. What are duplicate genes?
5. How do snurps function in splicing?
6. Write the mechanism of specialized transduction.
7. Mention the role of UvrA and endonucleases in DNA repair.
8. List the special features of a test cross.
9. What are tumor suppressor genes?
10. Define the term Reverse Genetics.
PART-B
Answer any FOUR
(4x10=40)
11. Elaborate protein synthesis in eukaryotes and prokaryotes. Add a note on the
degradation mechanism.
12. Explain as to how tryptophan metabolism is regulated.
13. Discuss the molecular mechanism of gene transfer during conjugation and
transformation.
14. Describe the cell cycle and also role of oncogenic viruses in inducing malignancy.
15. Elaborate DNA damage during DNA mutations.
16. What are sex influenced and limited traits? How do they differ from sex linked
traits? Give examples.
PART-C
Answer any TWO
(2x20=40)
17. Explain the functional elements of eukaryotic DNA organization in detail.
18. Discuss the various models of DNA replication with suitable diagrams.
19. Define transposable elements. Write in detail the types of transposition
mechanism.
20. Write in detail the modification in dihybrid ratios due to different kinds of
interactions of gene.
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