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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
B.Sc. DEGREE EXAMINATION – ADV.ZOOLOGY
FOURTH SEMESTER – APRIL 2011
AZ 4200 - BIOINFORMATICS
Date : 05-04-2011
Time : 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART – A
(10 x2=20)
ANSWER ALL IN A FEW SENTENCES
1. What are molecular probes ?
2. Define computational biology.
3. What are the steps involved in executing a C-program?
4. Distinguish AUTODOCK and PATCHDOCK.
5. Comment on PUBMED.
6. Draw a flow chat for molecular docking.
7. State genetic algorithm.
8. What do you know about mitochondrial proteome?
9. State the applications of NMR .
10. Expand: MMDB and SQL.
PART – B
(4 x 10 = 40)
BRIEFLY ANSWER ANY FOUR
11. Write notes on the applications of bioinformatics.
12. Highlight the principle and application of microarray technology.
13. How do you sequence DNA? Propose any one technology.
14. What do you know about computational evolutionary biology of mosquitoes?
15. Propose a flow chart for protein structure prediction.
16. How do you compile and run a ‘C’ programme for bioinformatics ?
PART – C
(2 x 20 = 40)
ANSWER ANY TWO IN DETAIL
17. Elucidate nucleic acid and protein sequence and structure databases.
18. Examine the concept of DNA computing using DNA chip.
19. How do bioinformatics tools and softwares aid in drug designing ?
20. Comment on the implication of : (a) X-ray crystallography (b) DNA
finger printing (c) Rasmol (d) UNIX operating system.
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