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Intro-BIOL318 Immunology
Instructor: Dr. Kathy Szick-Miranda
Office: Science I 316
Phone: 654-6165
Email: [email protected]
Web: www.csub.edu/~kszick_miranda
Office hours: M 10-12; T 3:30-5; W 10-11:30
Lecture and Discussion: T R 10:00-11:40am, Sci II 180
Intro-BIOL318 Immunology
Course Objectives: Upon completion of this course
students will be expected to:
•Describe the various cells and organs of the immune
system, including the role of each during the immune
response.
•Compare and contrast innate and acquired immunity,
including their specific components and effector
mechanisms.
•Describe antigens and antibodies and their interactions.
•Discuss the immune response to specific pathogens.
Intro-BIOL318 Immunology
Assignment Point Values:
Exam I
Exam II
Final Exam (Exam III)
Quizzes (top 5 scores)
TOTAL
100pts
100pts
100pts
50pts
350pts
Historical Perspective
Immunity - state of protection from an infectious disease.
430 BC – Greek historian Thucydides - Athenian plague
15th century – Chinese attempts to induce immunity
1718 – Mary Wortley Montagu – innoculated her children
1798 – Edward Jenner – milkmaids and cowpox/smallpox
Historical Perspective
Louis Pasteur
early 1880’s – Cholera and chickens
Attenuation hypothesis
1881 – Testing the hypothesis with
anthrax and sheep
1885 – Rabies vaccine
Historical Perspective
1890 - Behring and Kitasato – link serum to
immunity
1883 – Metchnikoff – links cells
(phagocytes) to immunity
early 1900’s – many functions of immune
serum
1930’s – Kabat - immunoglobulin/antibodies
1950’s – Glick – two types of lymphocytes
Historical Perspective
1900 – Paul Ehrlich – Selective theory
1950’s – Jerne, Talmadge and Burnet –
clonal selection theory
Historical Perspective
Infection and Immunity
pathogens – organisms causing disease
pathogenesis – the means by which disease-causing
organisms attach a host.
Innate and Adaptive Immunity
Innate
Adaptive
1st line of defense
2nd line of defense
Non-specific
mechanisms
Highly specific
mechanisms
Phagocytes and
recognition
molecules
Lymphocytes,
antigen specific
receptors, antibodies
Components of Adaptive Immunity
T Lymphocytes
Innate and Adaptive Immunity
Innate and Adaptive Immunity
Immune Dysfunction
Allergies and asthma
Graft rejection
Autoimmune disease
Immunodeficiency