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Contents
Chapter 1. General introduction and objectives
Chapter 2. Testing endocrine disruption in biota samples: a method to remove interfering lipids
and natural hormones
Chapter 3. Blood plasma sample preparation method for the assessment of thyroid hormonedisrupting potency in effect-directed analysis
Chapter 4. Transthyretin-binding activity of contaminants in blood from polar bear (Ursus
maritimus) cubs
Chapter 5. Effect-directed analysis to explore the polar bear exposome: the identification of
thyroid hormone disrupting compounds in plasma
Chapter 6. Effect-directed analysis (EDA) of genotoxic and thyroid hormone-disrupting
compounds in abiotic and biotic samples from aquatic ecosystems
Chapter 7. General discussion, concluding remarks and outlook
Summary
Samenvatting
Curriculum Vitae
List of publications
List of oral presentations
Acknowledgement