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Enteric defensins are essential regulators of intestinal micorbial ecology Nita Salzman Nature immunolgy 11, 76-83 The problem Friendly bacteria ?? ? Background Lumen Friendly bacteria Mucous membrane Innate proinflamatory response TL5,9 Il-1, a,Bbefensins Lamina Cytokines IgA DC Propria Tcell IL-17 Previously DEFA-5 Protection against Salmonella Hypothesis • Addition of DEFA5, kills Salmonella directly, therefore providing protection, or, • DEFA5 alters intestinal flora which in turn provides protection against the pathogen. Expression Bacterial colonisation mRNA So ..? • So far, • mice expressing functional DEFA5, have a different microbiological ecology. Which is not due to other paneth cell functions. Recipricating data SFB Total numbers Th-17 cells The problem refined Friendly bacteria IL-17 T cells Implications • • • • Crohns type diseases Probiotics Allergies Antibiotic treatments!
