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Transcript
Welcome to the continuation of Biol 213 Genetics! Genetics News What’s in the mail? • EditBase - DNA processing program • Mystery sequence Problem Set 3 now available Lab 2 - long Feedback welcome Upcoming events Monday, Sept 18: Problem day (Problem Set 3) Friday, Sept 22: Problem day (Problem Set 4) Monday, Sept 25: First exam (7:00 PM) Monday, Sept 25: in class….? Today’s events DNA Replication Integration of leading/lagging strand synthesis Inborn errors of metabolism How does alkaptonuria work Beadle & Tatum’s experiment with Neurospora How does alkaptonuria work DNA Replication How can DNA polymerase go left to right and right to left simultaneously? Relationship between genes and proteins One gene - many protein gene RNA Protein precursor Relationship between genes and proteins One gene - many protein Protein precursor lactose Lactose degrading enzyme maltose Maltose degrading enzyme Relationship between genes and proteins Many genes - many protein Relationship between genes and proteins Many genes - many protein One gene - One protein Phenylalanine degradation Dietary protein phenylalanine other amino acids tyrosine p-hydroxyphenylpyruvic acid homogentisic acid Homogentisic acid oxidase maleylacetoacetic acid Phenylalanine degradation Dietary protein phenylalanine other amino acids tyrosine p-hydroxyphenylpyruvic acid homogentisicacid acid Homogentisic Homogentisic acid oxidase maleylacetoacetic acid Black oxidation product Alkaptonuria Problems Phenylalanine degradation Dietary protein phenylalanine other amino acids Phenylalanine hydroxylase tyrosine p-hydroxyphenylpyruvic acid homogentisic acid maleylacetoacetic acid Phenylketones (neurotoxins) Life cycle of yeast How to get mutants in Neurospora Haploid Neurospora radiation Diploid Neurospora radiation screen 1000’s Auxotroph? No auxotrophs How to get mutants in Neurospora self cross 1000’s auxotroph? Could you do this with humans? back cross 1000’s self cross mixed mating types Analysis of Beadle & Tatum Expt 1. One gene - many enzymes 2. Many genes - one or more enzymes 3. One gene - one enzyme
