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Core-‐Clad Electrospun Fibers for Controlled Release Drug Delivery Ashley More+, Elizabeth Toby, Elizabeth Poyss Objec=ve: FabricaJon and analysis of a model transdermal drug delivery system comprised of natural and syntheJc biocompaJble submicron fibers for safe and effecJve controlled drug release. Cross-‐linked alginate cladding encapsulaJng a Polyacrylonitrile matrix with Diphenhydramine HCl (Benadryl®) Conclusions: • Model drug delivery system of Diphenhydramine HCl (Benadryl®) encapsulated in core-‐clad electrospun fibers of different clad composiJons and geometries. • Natural polymers, including alginate and chitosan, were used to improve biocompaJbility and biodegradability. • Release mechanisms best fit the Higuchi Model indicaJng a purely diffusional drug release through an insoluble matrix. Approach: • Coaxial electrospinning, a versaJle polymer processing technique, used to incorporate a rate-‐controlling barrier by encapsulaJng a model drug with a biocompaJble polymer cladding. • Structure and surface morphology characterized using Scanning Electron Microscopy (SEM). • Drug release rate determined by measuring absorbance in Ultraviolet-‐Visible Spectroscopy. Contact: Dr. Caroline Schauer Materials Science and Engineering Natural Polymers and Photonics Group (NPP) E-‐mail: [email protected] Phone: (215) 895-‐6797
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