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Transcript
Enzyme Active Site Fig. 13-08, p.413 HIV-1 Protease complexed with the inhibitor Crixivan (RED) made by Merck Competitive inhibition of the Opioid receptor Naloxone Morphine -A “Secondary Metabolite” that comes from the Poppy plant -It binds our opioid receptors triggering its pharmacological response Drug Discovery? Naltrexone Both of these compounds are examples of a competitive inhibitor of our opioid receptors. Used to treat Morphine (and other opioids) overdose and addiction More specifically they are: Opioid receptor antagonists – Which are compounds that bind a specific receptor, but do not trigger a response (or similar response). What happens when chemists get bored? Here is another… Buprenorphine or the IUPAC: (2S)-2-[(-)-(5R,6R,7R,14S)9α-cyclopropylmethyl-4,5-epoxy6,14-ethano-3-hydroxy6-methoxymorphinan-7-yl]3,3-dimethylbutan-2-ol Note for clarification: Competitive inhibition = enzyme Receptor antagonist = receptor that can trigger a response. But the drug discovery for these molecules and how they bind are the same!
