Download 02. spare receptors

SPARE RECEPTORS
DR. SHABANA ALI
SPARE RECEPTORS
 Total number of receptors present compared
with the number actually needed to elicit a
max. biological response
A
pharmacological system has spare
receptors if a full agonist can cause a max.
response when occupying only a fraction of
total receptor population
 Cont.
 Diverse molecular mechanisms responsible
for spare receptor
 Partial agonists can become full agonist if a
receptor reserve exist
 Spare receptor increase sensitivity t o drug
 If EC50 < Kd, spare receptors exist