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PROGRAM 17th Annual YARE Meeting in Berlin, October 02nd – 04th 2015 Conference Venue and Accommodation: Hotel Angleterre Friedrichstraße 31 10969 Berlin http://www.hotel-­‐angleterre.de/ Tel.: +49(30) 34 34 73 300 AREA MAP Important addresses: 1. Hotel Angleterre: Friedrichstraße 30, 10969 Berlin 2. Restaurant “Max und Moritz”: Oranienstraße 162, 10969 Berlin 3. Checkpoint Curry 207: Friedrichstraße 207, 10969 Berlin 4. Start Walking Tour: Checkpoint Charlie, crossing Friedrichstr./Mauerstr. 5. Restaurant “Zur Nolle”: S-­‐Bahnbogen 203, Georgenstraße, 10117 Berlin The closest subway station to Hotel Angleterre is Kochstraße, U6 Directions to Hotel Angleterre: Main Railway Station (Hauptbahnhof): Take local train S5 (direction Strausberg Nord) S7 (direction Ahrensfelde) or S75 (direction Wartenberg) for 1 stop to Friedrichstraße. At “Friedrichstraße” take subway U6 (direction Alt-­‐Mariendorf) to “Kochstraße”. Airport Tegel: Take bus 128 (direction Osloer Strase) to “Kurt-­‐Schumacher-­‐Platz”, change to subway U6 (direction Alt-­‐Mariendorf). Go 13 stops to “Kochstraße”. Airport Schönefeld: Take local train S45 (direction Westend) to “Tempelhof”. At “Tempelhof”, take subway U6 (direction Alt-­‐Tegel) to “Kochstraße”. FRIDAY Until 14.00 REGISTRATION AT HOTEL ANGLETERRE 14:00 INTRODUCTION (CONFERENCE HALL “LONDON”) 14:30 – 15:45 NEUROENDOCRINOLOGY (Chairs: Stephanie Fliedner, Mareike Stieg) 14:30 Verena Schuster: Influence of endogenous and exogenous female sex hormones on brain structure, function and connectivity – an fMRI study 14:45 Peer Herholz: Predicting usage of oral contraceptives & cycle phase with classifiers & representational geometries based on fMRI activation patterns 15:00 Jiesi Chen: Therapeutic potential of thyroid hormone analogs Triac and Ditpa in Allan-­‐Herndon-­‐Dudley Syndrome 15:15 Noelia Martinez-­‐Sanchez: Central thyroid hormone coordinates lipogenesis in liver and Brown Adipose Tissue through the autonomic nervous system 15:30 Zhi Zhang: Administration of thyrotropin-­‐releasing hormone (TRH) in the rat paraventricular nucleus (PVN) induces cold-­‐defense responses 15.45– 16:30 COFFEE BREAK 16:30 – 17:45 THYROID I (Chairs: Carolin Höfig, Henriette Undeutsch) 16:30 Sarah Paisdzior: Establishment of the sensitive NanoBRET™-­‐method for detection of GPCR-­‐interactions 16:45 Franziska Meyer: Thyroid hormones influence the energy metabolism in brain cells via Mct8 17:00 Nancy Schanze: The thyroid hormone metabolite 3-­‐T1AM exerts direct effects on thyrocytes in vivo and in vitro 17:15 Gina-­‐Eva Görtz: Orbital fibroblast hypoxic response impacts tissue remodeling in Graves’ orbitopathy 17:30 – 18:30 NUTRITIONAL EFFECTS IN ENDOCRINOLOGY (Chairs: Carmina Fuß, Eddy Rijntjes) 17:30 Frank Josef Möller: Soy isoflavone exposure through all life stages accelerates E2-­‐induced mammary tumor onset and growth but reduces tumor burden in ACI rats 17:45 Rene Hauptstein: Effects of isoflavone-­‐rich diet on transcript levels of enzymes of estrogen metabolism in female breast tissue of August Copenhagen Irish rats: Differences between short and long term intake 18:00 Kristina Paulsen: sdLDL is elevated in chronic inflammatory diseases and does not respond to anti-­‐cytokine therapies in humans 18:15 Julia Illner: Association of Period clock gene deficiency and liver inflammation in high-­‐fat diet induced non-­‐alcoholic steatohepatitis (NASH) 18:30 – 18:45 ANNOUNCEMENTS 19:15 – 20:00 TRANSFER TO RESTAURANT “MAX & MORITZ” 20:00 DINNER LECTURE Dr. Georg Munz (German Research Council, DFG): Get started! Get funded! Get Dinner! SATURDAY 9:15– 10:15 DIABETES AND OBESETY (Chairs: Alexander Fischer, Torsten Schröder) 9:15 Lev Prystupiuk: The Need to Determine Albuminuria in Screening Programs for Type 2 Diabetes Mellitus 9:30 Henry Karlsson: Weight loss following bariatric surgery normalizes cerebral opioidergic dysfunction in morbid obesity 9:45 Paulina Ormazabal: Amelioration of insulin signalling and inflammation in obese visceral adipose tissue by protocatechuic acid 10:00 Noushafarin Khajavi: GIP, GLP-­‐1 and glucagon based multi-­‐agonists modulate calcium influx and Gs signalling in human pancreatic β cells 10:15 – 11:00 COFFEE BREAK 11:00 – 12:15 ADIPOSE TISSUE (Chairs: Stephanie Fliedner, Torsten Schröder) 11:00 Rebecca Ölkrug: Discovering the Evolutionary Origin of Brown Adipose Tissue 11:15 Ineke Luijten: The effects of glucocorticoids on primary cultures of murine brown and white adipose tissue 11:30 Julia Kind: Fat in flames-­‐ The immune cells in adipose tissue 11:45 Anastasia Georgiadi: Fndc4, a close homologue of irisin binds and activates a novel orphan GPCR receptor 12:00 Alexander Fischer: Leptin: pyrexic rather than thermogenic 12:15 – 13:30 LUNCH BREAK 13:30 – 14:15 THYROID II (Chairs: Alexander Fischer, Carolin Höfig) 13:30 Lisbeth Harder: Catching Fire -­‐ Metabolic, Thermogenic and Cardiac Effects of Thyrotoxicosis in Mice 13:45 Steffen Mayerl: Thyroid hormone transporters Mct8 and Oatp1c1 govern muscle stem cell differentiation and muscle regeneration capacity 14:00 Jonathan Bank: From summer to winter, from hormone to behavior. What we can learn about Thyroid hormones from a seasonal animal 14:15 – 15:00 REPRODUCTIVE ENDOCRINOLOGY (Chairs: Eddy Rijntjes, Henriette Undeutsch) 14:15 Aleksandra Szybiak: The endocrine disrupting potential of phthalates in women with polycystic ovary syndrome (PCOS) 14:30 Polina Kulikova: Transplantation of bone marrow cells for the correction of the primary male hypogonadism in rats 14:45 Emmi Rotgers: A tug of war between RB and E2F3 controls sertoli cell differentiation 15:00 – 15:30 COFFEE BREAK 15:30 – 17:00 POSTER PRESENTATIONS P01 Barbara Aniol: Influence of Smoking on the pathogenesis of Graves` Orbitopathy P02 Henriette Undeutsch: Role of G12/G13 signaling in murine thyrocytes P03 Juliane Graß: Sweat-­‐inducing physiological challenges do not result in acute changes in hair cortisol concentrations P04 Isa Kolbe: SCN pacemaker function and the regulation of circadian adipose rhythms P05 Jana-­‐Thabea Kiehn: Influence of the circadian clock in leptin-­‐responsive neurons on energy homeostasis P06 Elke Tatjana Aristizabal Prada: Anti-­‐tumor effects of the novel human Mut T homolog 1 inhibitor TH588 in neuroendocrine neoplasms P07 Svenja Nölting: Lovastatin enhances the anti-­‐tumor potential of everolimus through inhibition of EGFR and AKT in neuroendocrine and non-­‐endocrine cells P08 Max Sander: The proposed molecular mechanism underlying isolated growth hormone deficiency (IGHD) caused by C53S mutation P09 Kristin Lucia: Hypoxia-­‐inducible factor 1α triggers growth hormone synthesis in GH-­‐secreting pituitary tumors P10 Ioana Hristov: Metabolic Syndrome in obese, bariatric patients P11 Sogol Gachkar: Adipokines, novel modulators of tail heat loss and brown adipose tissue thermogenesis? P12 Viktoria Köhler: Characterization of a novel mutation (p.Gly42Val) in a family with multiple endocrine neoplasia type 1 P13 Alfred Maukner: Individualized adjuvant chemotherapy with Streptozotocin in adrenocortical carcinoma P14 Matthias Auer: The metabolic regulation by sex hormones: A longitudinal metabolomics study in transgender persons P15 Joanna Stelmaszewska: Follicle stimulation hormone receptors are not expressed in human umbilical cord vessel endothelial cells 17:00 – 17:15 ANNOUNCEMENTS 17:15– 18:00 CURRYWURST BREAK AT “CHECKPOINT CURRY 207” 18:00 – 20:00 SOCIAL PROGRAM: GUIDED WALKING TOUR THROUGH BERLIN FROM 20:00 DINNER IN RESTAURANT “ZUR NOLLE” SUNDAY 9:30 – 10:45 ENDOCRINE CANCER (Chairs: Carmina Fuß, Tina Kienitz) 9:30 Larisa Bavykina: Thyroid cancer in patients with hyperthyroidism 9:45 Iulia Ioana: Gestational hyperparathyroidism, a rare but dangerous occurrence 10:00 Isabel Weigand: Differential expression of the PKA subunits in adrenocortical adenomas 10:15 Milena Doroszko: Gonadotropin releasing hormone (GnRH) antagonist treatment induces cell cycle arrest in gonadal somatic and adrenocortical cell tumors 10:30 Archik Das: Does Human Cytochrome P450 2W1 (CYP2W1) activate mitotane in the treatment of adrenocortical carcinoma? 10:45 – 11:20 COFFEE BREAK 11:20 – 12:05 ADRENALS (Chairs: Mareike Stieg, Tina Kienitz) 11:20 Carmina Teresa Fuß: High expression of C-­‐X-­‐C chemokine receptor type 4 in the zona glomerulosa and in aldosterone producing adenoma 11:35 Christian Gebhard: Characterization of CYP11B2 and HSD3B2 in aldosterone producing adenomas 11:50 Christina Berr: Muscle strength in Cushing’s syndrome 12:15 – 13:15 INVITED LECTURE Prof. Lutz Schomburg (Institut für Experimentelle Endokrinologie, Charité Berlin): The peer review process – Responding to reviewer comments 13:15 CLOSING REMARKS AND FAREWELL YARE would like to thank the following companies for their contribution to our 17th annual meeting: The 17th Annual Meeting of Young Active Research in Endocrinology (YARE) has been endorsed by the European Society of Endocrinology who has also provided financial support through an ESE Small Meeting Grant. Steering Committee contact: Carolin Höfig (Email: [email protected]) Department of Cell and Molecular Biology, Karolinska Institute, von Eulers väg 3, 17177 Stockholm, Sweden Tina Kienitz (Email: [email protected]) Medizinische Klinik m.S. Endokrinologie, Diabetes und Ernährungsmedizin, Charité, Charitéplatz 1, 10117 Berlin Eddy Rijntjes (Email: [email protected]) Institute of Experimental Endocrinology, Charité, Augustenburger Platz 1, 13353 Berlin Henriette Undeutsch ([email protected]) Department of Physiology, Institute for Biomedicine, Kiinamyllynkatu 10, 20520 University of Turku, Finland