Download antibody antigen interaction

PROPERTIES OF ANTIGEN
1. Foreignness
An antigen must be a foreign substance.
2. Molecular Size
The most active immunogens tend to have a molecular mass of 14,000 to 6,00,000 Da.
3. Chemical Nature and Composition
Antigens are mainly proteins and some are polysaccharides.
4. Physical Form
In general particulate antigens are more immunogenic than soluble ones.
5. Antigen Specificity
Antigen Specificity depends on the specific actives sites on the antigenic molecules
6.Organ Specificity
Organ specific antigens are confined to particular organ or tissue.
ANTIBODY ANTIGEN INTERACTION
Antigen-antibody reaction, is a specific chemical interaction between antibodies produced by B cells of
the white blood cells and antigens during immune reaction. It is the fundamental reaction in the body by
which the body is protected from complex foreign molecules.
Biological Aspects of Antibody-Antigen Interaction
1. T-Dependent and T-Independent Immune Responses
"Normal" immune responses depend on the participation of T cells.
2. Maturation of the Immune Response
Antibodies isolated soon after an initial antigen exposure differ from those obtained later in the
response or after a second administration of antigen.
3. Anti-idiotype Antibodies
4. Heterophile Antibodies and Molecular Mimicry
An antibody that reacts with an antigen to which the host has not been exposed is termed a
"heterophile antibody"
5. Polyspecific Antibodies