Download hour - Universitatea de Medicină şi Farmacie "Gr.T. Popa"

Universitatea de Medicină şi Farmacie „Grigore T. Popa” Iaşi
Comisia pentru asigurarea calităţii
DISCIPLINE RECORD/ COURSE / SEMINAR DESCRIPTION
1. Information about the program
1.1.
1.2.
1.3.
1.4.
1.5.
1.6.
UNIVERSITY: “GRIGORE T. POPA” UNIVERSITY OF MEDICINE AND PHARMACY OF
IAŞI
FACULTY: PHARMACY SCHOOL / DEPARTMENT: PHARMACEUTICAL SCIENCES I
SUBJECT: PHARMACEUTICAL PHYSICS
STUDY FIELD: MEDICINE
STUDY CYCLE: UNDERGRADUATE
STUDY PROGRAMME: IN ENGLISH
2. Subject data
2.1. SUBJECT: PHARMACEUTICAL PHYSICS
2.2. Module leader: Prof. Mihaela Baican, PhD, Lecturer Florina Crivoi, PhD
2.3. Seminar leader: Prof. Mihaela Baican, PhD, Lecturer Florina Crivoi, PhD
2.4. Year of I
2.5. Semester in I/II 2.6. Evaluation E1/E2 2.7. Subject Obligatory
study:
which is taught
type
status
3. Duration of the course (hours per semester)
3.1. Number of
hours / week
4 (1st sem.)
4 (2nd sem.)
3.2. Number of
hours / week
1 (1st sem.)
2 (2nd sem.)
3.3.Seminar /
lab
3 (1st sem.)
2 (2nd sem.)
3.4.Total number
of learning hours
112
3.5.Total number
of learning hours
14 (1st sem.)
28 (2nd sem.)
42
3.6.seminar /
lab
42 (1st sem.)
28 (2nd sem.)
70
hours
35/ 38
20/10
20/14
5/ 5
4/2
10/80/67
150/125
6/5
3.7.Distribution of activities in the course (1st sem./ 2nd sem.)
Study based on the manual, printed course, bibliography and notes
Additional research in the library, on specialized e-platforms and field study
Preparation for seminars, practical courses, portfolios and essays
Tutoring
Assessment
Other activities
3.8. Number of hours of individual study
3.9. Number of hours per semester
3.10. Number of ECTS
4. Previous Knowledge (if applicable)
4.1. course related
4.2. skill related
It is not the case
Mathematics and physics elementary notions
5. Requirements (if applicable)
5.1. course conditions
5.2. seminar / laboratory conditions
6. Specific Skills Acquired
Videoprojector, course support
Specific laboratory devices
Professional skills displayed
by knowledge and skills



Transversal skills (role skills,
professional and personal
skills)





Evaluation of some physical factors that influence the
pharmaceutical products preservation (temperature,
humidity, atmospheric pressure);
Appreciation of purity degree and quality of the
substances in different aggregation forms, using the
studied methods;
Determination of some physical parameters having an
important part in conditioning and storing of
a pharmaceutical substance or a pharmaceutical product
Team work skills;
Use of known concepts in new contexts;
Use of theoretical and practical knowledge in solving specific
problems of the professional qualification;
Oral and written communication skills specific to the
profession,
problem solving and decision making;
Opening for lifelong learning, autonomy and responsibility,
respect for professional ethics.
7. Course Objectives (confirmed by the grid of specific skills acquired)
7.1. General Objective
7.2. Specific Objectives
Acquiring knowledge about physics concepts applied in qualitative and
quantitative characterization of different substances that are used in
pharmaceutical preparations.
Acquisition of knowledge on physics concepts with applications in
biomedical domain;
Acquisition of skills on working with laboratory equipment, in order to
characterize substances in solid and liquid state, as well as assessing their
purity degree.
8. Contents
8.1. Course
Fundamental and derivative physical quantities. Dimensional
equation. Motion types
Dynamics principles; centripetal and centrifugal forces. Statics
notions. General conditions of equilibrium of bodies
Oscillations and waves. Oscillatory motion; elastic waves; plane
wave equation; waves interference
Sound waves; Doppler effect; ultrasounds
Fluids. Fluids statics. Fundamental principle of hydrostatics;
Archimedes’s principle. Fluids dynamics. Bernoulli’s equation
Dynamic of real fluids; Blood viscosity. Sedimentation and
centrifugation. Blood viscosity
Surface phenomena in liquids. Pressure created by a curved
liquid surface; contact phenomena; capillarity
Surface phenomena at the contact between three media;
superficial tension of solutions; thermal expansion; appreciation
of drugs stability Transport phenomena (osmosis and diffusion)
Gaze perfecte; gaze reale; izotermele Andrews
Coulomb’s law; Electrostatic field
Electric dipole; polarization of atoms and molecules; electric
current; Ohm’s law; applications of superconductors
Joule’s effect; electric networks in permanent regime; motion of
Teaching
methods
videoprojector
Observations
videoprojector
2 hours
videoprojector
2 hours
videoprojector
videoprojector
2 hours
2 hours
videoprojector
2 hours
videoprojector
2 hours
videoprojector
2 hours
videoprojector
videoprojector
videoprojector
videoprojector
2 hours
2 hours
2 hours
2 hours
videoprojector
2 hours
2 hours
charged particles in electric and magnetic fields
Photometry; principles of geometric optics; light refraction and
videoprojector
2 hours
reflection
Thin lenses; characteristics of optical instruments
videoprojector
2 hours
Polarization of light (polarization types, rotatory polarization)
videoprojector
2 hours
Light absorption; light dispersion
videoprojector
2 hours
X-Ray (production and scattering, characteristic spectra,
videoprojector
2 hours
properties, attenuation law, applications); photoelectric effect
Atomic nucleus (properties, Mass spectrograph, mass defect,
videoprojector
2 hours
nuclear binding energy, internuclear forces)
Natural radioactivity; radiations emitted by the nuclei; decay
videoprojector
2 hours
nuclear laws
Radiopharmaceuticals (properties, classification, radioisotopes
videoprojector
2 hours
preparation, administration ways)
Bibliography
1. Young DH, Freedman RA. University Physics. San Francisco : Pearson Education, Inc., 2008.
2. Sanny J, Moebs W. University Physics. WCB Publishers, 1996.
3. Crivoi F, Baican M. Physical methods applied in pharmacy. Iasi: Ed. “Gr. T. Popa“, 2012.
4. Sampson B. Textbook of radiopharmacy, Theory and Practice, 3-rd edition; Gordon and Breach
Publishers, 1999.
5. Courrière Ph. Physique et biophysique pharmaceutiques. Paris : Masson, 1990.
8.2. Seminar / Practical lessons
Teaching
Observations
Methods
Work protection. Physical quantities. Measurement of the
3 hours
physical quantities. Errors. Presentation of the results
Measurement of density for solid state
3 hours
Measurement of density for liquids by pycnometer method
3 hours
Determination of liquids density using the densimeter and the
3 hours
Mohr-Westphal balance
Evaluation of some physical factors which influence the
3 hours
conservation of the pharmaceutical products
Tracing of the calibration curve for a thermocouple
3 hours
Determination of the superficial tension coefficient
3 hours
Modification of the superficial tension coefficient by the surface
3 hours
active substances
Determination of crioscopic point of a solution
3 hours
Measurement of the specific heat for the solid substances
3 hours
Determination of melting specific latent heat of ice
3 hours
Determination of the viscosity coefficient using Ostwaldt
3 hours
viscometer
3 hours
Variation of the viscosity coefficient with temperature
3 hours
Measurement of the viscosity coefficient of glycerin by Stokes
method
Determination of surface free energy for solids. Contact angle
2 hours
method
2 hours
Measurement of the electric resistance using Wheatstone bridge
2 hours
Study of the dialyse phenomenon using Kohlrausch bridge
2 hours
Determination of the mechanical equivalent of the calory. Joule
2 hours
effect
2 hours
Determination of osmotic pressure with Dutrochet device
2 hours
Determination of the focal distance of a lens
2 hours
Measurement of the refractive index of liquids using Abbé
refractometer
2 hours
Determination of the optical microscope qualities: magnification
and diameter of the visual field
2 hours
Application of the microscope for measuring the dimensions of
the penicillin crystals
2 hours
Determination of the refractive index of a glass blade using the
microscope
2 hours
Tracing of the calibration curve of the prism spectroscope.
Subtance identification using spectra in visible domain
2 hours
Determination of the concentration of a solution using Spekol
photocolorimeter
2 hours
Using of the polarimeter for measurment the concentration of a
glucose solution
Atomic absorbtion spectrophotometry. IR -spectrometry
(demonstrative work)
Bibliography
1.
Crivoi F, Baican M. Physical Methods Applied in Pharmacy.Iasi: Grigore T. Popa Publishing
House U.M.F. Iaşi, 2012.
2.
Young DH, Freedman RA. University Physics 12-th edition, Pearson International 2008.
3.
Breithaupt J. Understanding physics for advanced level. 2-nd edition, Stanley Thornes Publisher
Ltd. 1990.
4.
Sanny J, Moebs W. University Physics, Johnson M Eds. Brown Wm C Publishers 1996.
9. The agreement between the course contents and the expectations of the
representatives of the epistemic communities, professional associations and
employers in the field related to the program
Physics course provides to the first year students a number of notions very useful in their training as
future pharmacists, putting them on hand a multitude of techniques that enable them - with the chemical
methods - a comprehensive characterization of pure substances that are part of pharmaceutical products.
These skills acquired after attending Pharmaceutics Physics Course will be of a real use to the future
graduate, whether will choose to work in industry, in pharmacy, or will choose a career in academia.
10.Assessment
Activity
10.4. Course
10.5.
Seminar
Practical lessons
10.1.
Assessment
criteria
Acquiring of the notions
reached at the course
/ Learning the theoretical
notions met in practical
works and acquiring
skills in the use the
laboratory equipment
10.2.
Assessment
methods
Written exam from
course content
Oral evaluation during
the semester and written
tests from laboratory
notions
10.3. Percentage of the
final grade
50 %
50 % (- 15% represent
the continuous testing
during the semester and
35% - represent the final
testing by the practical
works examination)
Minimal standard of proficiency: Minimum mark to pass: 5
Date:
16.12.2014
Date of indorsement in
the Council of the Department
Signature of Coordinator for Teaching Activities
Lecturer Florina Crivoi, PhD
Prof. Mihaela Baican, PhD
Signature of The Department Director
Assoc. Prof. Gladiola Țântaru, PhD