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Addison’s Disease
Miranda Chan, Aliny Ater, Nathania Rebong
What is Addison’s Disease?
• Addison Disease is an
endocrine disorder affecting
the body’s hormonal activity
by decreasing the
production of important
hormones.
prlog
Cause
• Addison’s Disease is caused by an
autoimmune disorder, in which your
immune system produces antibodies that
attack your adrenal cortex.
• This causes the adrenal cortex to release
insufficient amounts of cortisol and
aldosterone.
Getting to know Cortisol…
Cortisol targets the liver, muscles, skin and adipose tissues.
• In the liver, cortisol promotes gluconeogenesis.
• Within the muscles, cortisol promotes the breakdown of
lean tissue into amino acids.
• In the skin, cortisol promotes vasoconstriction.
• In the adipose tissue, cortisol promotes the breakdown of
fats into fatty acids and glycerol.
• Cortisol can also suppress the immune system.
Symptoms
• Fatigue
• Weakness
• Loss of appetite
• Weight gain
NIH Publication
• Vomiting
• Diarrhea
• Nausea
• Low blood pressure
• Hyper pigmentation
Fitnessgoop
What is Affected?
• Liver
• Muscles
• Skin
• Immune System
Flowchart
Kidport
Treatment
• The main treatment is to replace the
hormones that are lost by taking
steroid preparation. Cortisol can be
replaced by taking hydrocortisone
tablets, and fluodrocortisone acetate
tablets can substitute the aldosterone
hormone.
• It is also advised to include an
increased amount of salt in the
patient’s diet.
Pharma Division
Genetic or not?
• If both parents have endocrine disorders
it is highly likely their child will obtain
Addison’s disease
• Addison’s disease is not genetic however
a certain piece of DNA coding has been
found in a number of people with
Addison’s disease that is also present in
people with other autoimmune disorders.
• Research has suggested that up to half of
all people with autoimmune Addison’s
disease will likely have another
autoimmune condition.
David DiSalvo, Forbes
Community support
If anyone you know is diagnosed with Addison’s Disease, please contact:
The Canadian Addison Society
193 Elgin Avenue West
Goderich, ON
N7A 2E7
1-888-550-5582
Or visit
http://www.addisonsociety.ca
Metrolic
References
1.
"Addison's disease - Ottawa Regional Hospital and Healthcare Center."A.D.A.M
Multimedia Encyclopedia . N.p., n.d. Web. 4 Apr. 2012.
<http://ottawaregional.adam.com/content.aspx?productId=117&pid=1&gid=000378>.
2. "Addison's disease - definition of Addison's disease in the Medical dictionary - by the Free
Online Medical Dictionary, Thesaurus and Encyclopedia.." Medical Dictionary. N.p., n.d.
Web. 4 Apr. 2012. <http://medical-dictionary.thefreedictionary.com/Addison''s+disease>
3.
"Addison's Disease - Symptoms, Tests, Treatment." Children's Hospital Boston. N.p., n.d.
Web. 4 Apr. 2012.
<http://www.childrenshospital.org/az/Site1680mainpageS1680P0.html>
4.
"Addison's disease - MayoClinic.com."Mayo Clinic. N.p., n.d. Web. 4 Apr. 2012.
<http://www.mayoclinic.com/health/addisons-disease/DS00361>.
5.
"Addison's Disease - Causes, Symptoms, Treatment, Diagnosis - Condition Factsheets C-Health." C-Health. N.p., n.d. Web. 4 Apr. 2012.
<http://chealth.canoe.ca/condition_info_details.asp?disease_id=331>.