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So, What’s Aging?
Aging is a shift in our
reality!
So What’s Reality?
Created by Dr. Edward Lakatta, Dr. Harold Spurgeon, and Dr. Victor Maltsev
1
1
Reality emerges from a mutually coupled
(enslaved) system of DNA and its
environment
DNA
Environment
Environment
Environment
Environment
2
Reality Is A System of Mutually Enslaved DNA and its Environment
Sun, planets, Moon, asteroids, Sputnik
O2, CO2, smoke
Geographic, climate, radiation,
pollutions, gravity
Traditions, Religion,
“Mandates”
Friends, Relatives, Pets,
Plants, Bacteria, Viruses
Soma, Psyche, and emergent
characteristics: Personality,
Cognition, Innate Brain, Behavior,
Lifestyle, Nutrition, Exercise
DNA
Organ-to-organ communication:
Brain-Nerves, Cardiovascular–
circulation, Endocrine-circulating
goodies
Extracellular matrix
Organelles, mitochondrial DNA, microRNA
Chromatin, Transcription factors,
HATS, HDACS
Heredity
3
Aging is a constellation of failures in DNA-Environment system over time
Failing
Interactions
 Signals
 Sensing of Signals
 SignalDNA
Transmission
 Response to Signals
 Proteostasis
Energy rundown
4
Aging is:
A constellation of DNA-Environment system
Failures over time, that result in Altered Cell
Tissue and Organismal Phenotype Characteristics
Cells
Tissues
Organs
Organism
Images from Mechanisms of Aging
5
SO!
Is Aging, per se,
A Disease?
6
“Aging and disease
are not
synonymous. There
are processes of
aging and
etiologies of
disease. The
relationship
between the two
are important, but
not inevitable”
Nathan Shock, Ann. Rev.Physiol. 1961
7
8
“... to draw a
distinction
between disease
and normal aging
is to attempt to
separate the
undefined from
the undefinable”
J.G. Evans, Research and The Aging Population 1988
9
So
What’s Reality?
THIS is REALITY!