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Save the Date for the 2014
Keystone Symposia meeting on:
Tumor Metabolism
March 16–21, 2014
Whistler Conference Centre,
Whistler, British Columbia, Canada
Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III
and Peter K. Jackson
joint with the conference on “Metabolism and Angiogenesis”
The conference will:
• Investigate the causal roles played by altered metabolism and epigenetics in cancer as well as
the resulting potential of metabolic and epigenetic enzymes to serve as a basis for new ways
of imaging and treating cancer;
• Bring together experts from the fields of both cancer metabolism and epigenetics;
• Facilitate additional cross-pollination across fields through the joint pairing with the meeting
on “Metabolism and Angiogenesis.”
Discounted Abstract Deadline: November 18, 2013
Student/Postdoc Scholarship Application Deadline: November 18, 2013
Abstract Deadline: December 17, 2013
Discounted Registration Deadline: January 15, 2014
For more information and to view the full program,
visit www.keystonesymposia.org/14X6
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Tumor Metabolism (X6)
Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson
Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc.
Supported by an educational donation provided by Amgen.
Metabolism and Angiogenesis (X5)
Scientific Organizers: Peter F. Carmeliet and Michael Simons
March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada
Supported by the Directors' Fund
Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014
SUNDAY, MARCH 16
Arrival and Registration
MONDAY, MARCH 17
Keynote Session (Joint)
M. Celeste Simon, University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism
Steven L. McKnight, University of Texas Southwestern Medical
Center, USA
Acetate Consumption as a Potential Vulnerability of Certain Types of
Human Tumors
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes
Markus Jabs, German Cancer Research Center, Germany
Short Talk: Notch Signaling Regulates Systemic Energy Metabolism
Poster Session 1
TUESDAY, MARCH 18
Isocitrate Dehydrogenase (X6)
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The von Hippel-Lindau Tumor Suppressor Protein: Insights into
Oxygen Sensing and Cancer Metabolism
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Novel Metabolic Pathways in Cancer I (Joint)
Epigenetic Control by Mutant IDH
Matthew G. Vander Heiden, Massachusetts Institute of Technology,
Elizabeth Maher, University of Texas Southwestern Medical Center,
USA
USA
Metabolic Pathways Important for Tumor Growth and Survival
Metabolic Imaging of IDH Mutant Brain Tumors
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Katharine Yen, Agios Pharmaceuticals, USA
Amino Acids, Sugars and Cancer Metabolism
AG-221 Offers a Survival Advantage in a Primary Human IDH2
Karen H. Vousden, Crick Institute, UK
Mutant AML Xenograft Model
p53-Pathway Mediated Metabolic Regulation
Christian Metallo, University of California, San Diego, USA
Ralph J. DeBerardinis, University of Texas Southwestern Medical
Short Talk: Exploiting Oncogenic IDH Mutations to Identify
Center, USA
Therapeutic Targets and Annotate Compartmentalized Pathway
Metabolic Versatility in Cancer Cells
Function
Douglas R. Green, St. Jude Children's Research Hospital, USA
Yoko Ogawara, National Cancer Center Research Institute, Japan
Balancing Act: Caspases and RIP Kinases in Cell Death and
Short Talk: Critical Roles of the IDH2 Mutation in Development and
Development
Maintenance of Acute Myeloid Leukemia
Succinate Dehydrogenase and Fumarate Hydratase (X6)
Metabolism and Vascular Branching (X5)
*Matthew G. Vander Heiden, Massachusetts Institute of Technology, *Luisa Iruela-Arispe, University of California, Los Angeles, USA
USA
Michael Potente, Max Planck Institute for Heart and Lung Research,
Patrick J. Pollard, University of Edinburgh, UK
Germany
Oncometabolites: Linking Altered Metabolism With Cancer?
Linking Angiogenesis and Metabolism through FOXO Transcription
Eyal Gottlieb, Technion Integrated Cancer Center, Israel
Factors
Revealing New Metabolic Networks in FH-Deficient Tumors
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Navdeep S. Chandel, Northwestern University, USA
Targeting Endothelial Metabolism: Principles and Strategies
Targeting Mitochondrial Metabolism for Cancer Therapy
Annika Keller, University Hospital Zürich and Uppsala University,
Paul-Joseph P. Aspuria, Cedars-Sinai Medical Center, USA
Switzerland
Short Talk: Succinate Dehydrogenase Inhibition Leads to
Endothelial-Pericyte Signaling and Brain Disease
Epithelial-Mesenchymal Transition and Reprogrammed Carbon
Kari K. Alitalo, University of Helsinki, Finland
Metabolism
VEGF-B in Metabolic Reprogramming and Cardiovascular Disease
Hilary A. Coller, University of California, Los Angeles, USA
Metabolism and Angiogenesis: Bidirectional Cross-Talk (X5)
Tumor Stromal Cells
*Adrian L. Harris, University of Oxford, Weatherall Institute of
Peter D. Westenskow, The Scripps Research Institute, USA
Molecular Medicine, UK
Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide
Zoltan P. Arany, University of Pennsylvania, USA
Erucamide for Maintenance of the Ocular Vasculature
Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes
Pengchun Yu, Yale School of Medicine, USA
Massimo Santoro, Vesalius Research Center, Belgium
Short Talk: Regulation of Lymphangiogenesis by FGF Signaling
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells
* Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Tumor Metabolism (X6)
Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson
Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc.
Supported by an educational donation provided by Amgen.
Metabolism and Angiogenesis (X5)
Scientific Organizers: Peter F. Carmeliet and Michael Simons
March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada
Supported by the Directors' Fund
Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014
Lactate and Monocarboxylate Transporters (X6)
Ubaldo E. Martinez Outschoorn, Thomas Jefferson University, USA
Talk Title to be Announced
Jacques Pouysségur, University of Nice, France
Targeting Lactate/H+ Symporters for Cancer Therapy
John Kurhanewicz, University of California, San Francisco, USA
Using in Vivo Hyperpolarized 13C MR Imaging for Measuring
Metabolic Fluxes Important to Prostate Cancer Progression and
Therapeutic Response
Sunghee Park, Duke University Medical Center, USA
Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled
Mitochondrial Oxidative Metabolism in Breast Cancer
Metabolism and Anti-Angiogenic Therapy (X5)
Dai Fukumura, Massachusetts General Hospital, USA
Vascular Normalization and Metabolic Microenvironment
Patrizia Agostinis, KU Leuven, Belgium
Tumor Vessel Normalization by Chloroquine Independent on
Autophagy Blockage
Olivier Feron, Université Catholique de Louvain, Belgium
Targeting Lactate and Glutamine Metabolism in Endothelial Cells
Adrian L. Harris, University of Oxford, Weatherall Institute of
Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy
Guy Eelen, Vesalius Research Center, KU Leuven, Belgium
Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells
Novel Metabolic Pathways in Cancer II (X5)
Leads to Vessel Branching Defects
*M. Celeste Simon, University of Pennsylvania, USA
Stephanie M. Cossette, Medical College of Wisconsin, USA
James M. Phang, NCI at Frederick, National Institutes of Health, USA Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an
The Proline Regulatory Axis: Metabolic Reprogramming in Cancer
AMPK Family Member that Is Essential for Cardiac Metabolism in vivo
Yury I. Miller, University of California, San Diego, USA
Poster Session 3
Cholesterol Efflux and Angiogenesis
†
Natalie Sheng Jie Lim , National University Singapore, Singapore
Workshop: Monitoring Metabolism (X6)
Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase
Hilary A. Coller, University of California, Los Angeles, USA
Inhibitor and Lysophospholipid Approach
Metabolism of Quiescent Cells
Hwee Ying Lim, National University of Singapore, Singapore
Linda C. Hsieh-Wilson, California Institute of Technology, USA
Role of Lymphatic Vessels in Cholesterol Clearance and the
The Interplay of Protein Glycosylation and Cancer Metabolism
Involvement of High-Density Lipoproteins in Regulating Lymphatic
Alan Saghatelian, The Salk Institute for Biological Studies, USA
Function
Protein-Metabolite Interactions
Brian W. Wong, Vesalius Research Center, Belgium
Sakino Toue, Ajinomoto Co., Inc, Japan
Short Talk: Investigating the Metabolism of Venous and Lymphatic
Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue
Endothelial Cells
Chemical Derivatization for Visualizing Multiple Amino Acids in
Human Colon Cancer Xenografts
Poster Session 2
WEDNESDAY, MARCH 19
Metabolism and Epigenetic Enzymes (X6)
Lucy A. Godley, University of Chicago, USA
Regulation of Hematopoiesis by 5-Hydroxymethylcytosine
Chuan He, University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation
Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging
Paul Guilhamon, University College London Cancer Institute, UK
Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New
Interaction Partner for TET2
Hong-Wu Chen, University of California, Davis, USA
Short Talk: Reprogramming Metabolism for Cancer Therapeutic
Resistance by Histone Methylases
Lipid Metabolism (X6)
Daniel K. Nomura, University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional
Proteomic and Metabolomic Platforms
Gerald Hoefler, Medical University of Graz, Austria
Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor
Gene
Ernst R. Lengyel, University of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes
Jurre J. Kamphorst, CR-UK Beatson Institute and University of
Glasgow, UK
Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by
Scavenging Fatty Acids from Lysophospholipids
* Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Tumor Metabolism (X6)
Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson
Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc.
Supported by an educational donation provided by Amgen.
Metabolism and Angiogenesis (X5)
Scientific Organizers: Peter F. Carmeliet and Michael Simons
March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada
Supported by the Directors' Fund
Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014
Metabolism and Pathological Angiogenesis (X5)
Yoshiaki Kubota, Keio University, Japan
Oxidative Stress as a Target for Anti-Angiogenic Therapy
*Michael Simons, Yale University, USA
Vascular Fate Determination
Massimiliano Mazzone, KULeuven - VIB, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications
for Cancer
Tony Walshe, Novartis, USA
Short Talk: Mitochondrial Oxidative Phosphorylation and Redox
Signaling Govern Endothelial Cell Fate Decisions
Sara Zanivan, CRUK Beatson Institute, UK
Elucidating Endothelial Metabolism Using Quantitative Proteomics
Ulrike Harjes, University of Oxford, UK
Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding
Protein 4
Miguel Quintela-Fandino, Spanish National Cancer Research
Centre, Spain
Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment
Plus Phenformin in Breast Cancer
Anuradha Doddaballapur, Institute of Cardiovascular Regeneration,
Germany
Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate
Endothelial Metabolism by Repressing PFKFB3
THURSDAY, MARCH 20
Novel Cancer Metabolic Targets (Joint)
Almut Schulze, University of Würzburg/Theodor-Boveri Institute,
Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of
Cancer Cells
Jonathan Hurov, Agios Pharmaceuticals, USA
Investigation of Glutaminase (GLS1) Dependency in Cancer Cells
Tom O'Brien, Genentech, Inc., USA
and
Peter K. Jackson, Stanford University, USA
Inhibiting Glycolysis with a New LDHA Inhibitor
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery
Institute, USA
Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases
Results in Impaired Growth of p53 Deficient Tumors by Mediating
Changes in Metabolism
Kristen E.N. Scott, H. Lee Moffitt Cancer Center & Research
Institute, USA
Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is
Required for B-Lymphoma Survival
FRIDAY, MARCH 21
Departure
Novel Cancer Metabolic Targets II (X6)
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Crosstalk between Metabolic and Signaling Pathways in Cancer
Sandaruwan Geeganage, Eli Lilly and Company, USA
Targeting Metabolic Reprogramming for Cancer – A Pharma
Perspective
Nissim Hay, University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy
Metabolism and Angiogenesis: Therapeutic Implications (X5)
*Massimiliano Mazzone, KULeuven - VIB, Belgium
* Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5.
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