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Adrenergic-Blocking Agents
I.
Alpha-Blockers
A. Action
1. blocks alpha1 receptor sites causing vasodilation and decreased BP
B. Therapeutic Uses
1. Antimigraine: Ergot alkaloids constrict dilated arteries going to brain
2. Oxytocin: controls post-partum bleeding
3. Antihypertensives and symptoms of BPH: Alpha 1 blockers- zosins:
4. Pheochromocytoma: an adrenal gland tumor
C. Drug Profiles
 Ergotamine tartrate (Ergostat)
 Phenoxybenzamine hydrochloride (Dibenzyline)
 Phentolamine (Regitine)
 Prazosin (Minipress)
 Tolazoline (Priscoline)
 Tamsulosin (Flomax)
II. Beta-Blockers
A. Action
1. Competes with and blocks norepinephrine and epinephrine at receptors sites
2. Blocks SNS stimulation
3. Blocks myocardial stimulation
4. Slows conduction through the SA and AV nodes
5. Impairs catecholamine mediated glycogenolysis
6. Impairs secretion of insulin
7. Constrict bronchioles
B. Therapeutic Uses
1. Angina- myocardial oxygen consumption
2. Cardioprotective3. Dysrhythmias-Slows conduction through SA and AV nodes
4. HTN- SNS stimulation,  renin
5.  IOP by  production of aqueous humor and minimal  outflow
C. Drug Profiles
Cardioselective
 Acebutolol (Sectral)
 Atenolol (Tenormin)
 Esmolol (Brevibloc)
 Metoprolol (Lopressor, Toprol XL)
 Betaxolol (Betoptic)
Non-cardioselective
 Propranolol (Inderal)
 Labetalol (Normodyne, Trandate)
 Sotalol (Betapace)
 Carvedilol (Coreg)
 Timolol (Timoptic)
D. Side Effects (see pg. 315 Tables 19-2 and 19-3)
 Bradycardia
 Hypotension
 Hypoglycemia
E. Teaching
 how to take HR and BP everyday
 when to hold the medication
 monitoring blood glucose closely
 change position slowly