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Supplemental Table 1. Summary of study information included in the analysis
Colorectal cancer
Gastric cancer
Cance
r type
Author
Year(Ref.)
Countr
y
Canc
er
sub
type
Samp
le
type
Conc
Chan
ge
Chen 2014,(1)
China
GC
Plasma
Fu 2014,(2)
Tsujiura 2014,(3)
Zhu 2014,(4)
Peng 2014,(5)
Kim 2013,(6)
Li 2013,(7)
Gorur 2013,(8)
Shiotani 2013,(9)
Cai 2013(10)
Xu 2013,(11)
Li 2013,(12)
Zhang 2012,(13)
Wang 2012,(14)
Zhou 2012, (15)
China
Japan
China
China
Korea
China
Turkey
Japan
China
China
China
China
China
China
GC
GC
GC
GC
GC
GC
GC
GC
GC
GC
GC
GC
GC
GC
Plasma
Plasma
Plasma
Serum
Serum
Plasma
Plasma
Serum
Plasma
Serum
Plasma
Serum
Serum
PB
Down
Up
Up
Up
Up
Up
Up
Up
Down
Up
Up
Down
Up
Down
Up
Up
Liu 2012,(16)
China
GC
Serum
Up
Valladares 2012,(17)
Konishi 2012,(18)
Spain
Japan
GC
GC
Blood
Plasma
Li 2012,(19)
China
GC
Plasma
Up
Up
Up
Down
Song 2012,(20)
China
GC
Serum
Up
Zheng 2011,(21)
Liu 2011,(22)
Zhou 2010,(23)
China
China
China
GC
GC
GC
PB
Serum
PB
Tsujiura 2010,(24)
Japan
GC
Plasma
Toiyama 2014,(25)
Japan
CRC
Serum
Wang 2014,(26)
China
CRC
Serum
Du 2014,(27)
Zanutto 2014,(28)
China
Italy
CRC
CRC
Plasma
Plasma
Up
Up
Up
Up
Down
Up
Up
Down
Up
Up
Ogata 2014,(29)
Japan
CRC
Serum
Up
Studied microRNAs
miR-122
miR-192
miR-222
miR-18a
miR-16, -25, -92a, -451, -486-5p
miR-425, -191
miR-106b, -223
miR-199a-3p
miR-195-5p
miR-106b, -21, let-7d
miR-221, -106b, -20a
miR-320a
miR-151-5p, -199a-3p
miR-375
miR-21
miR-421
miR-320c, -1182, -150*, -936, -923, -557
miR-187*, -371-5p, -378
miR-200c
miR-451, -486
miR-223, -21
miR-218
miR-221, -744, -376c, -27a, -27b, -222, -191,
let-7e
miR-21
miR-1, -20a, -27a, -34, -423
miR-17, -106a
miR-17-5p, -21, -106a, -106b
let-7a
miR-200c
miR-21, let-7g
miR-31, -92a, -181b, -203
miR-21
miR-378, -21
miR-1268, -1290, -1308, -181b, -181d, -1915, 483-5p, -638, -1224-5p
Let 7a, miR-23a, -1229, -1246, -150, -21, -223
Sample
(Cases
/Controls)
Stage (Ⅰ/Ⅱ/Ⅲ/
Ⅳ)
Assay methods
Age (year) (Cases
/Controls)
36/36
0/0/13/23
RT-qPCR
56(48-61)/59(48-61)
114/56
104/65
88/142
57/58
31/15
80/70
20/190
64/64
90/90
94/103
180/80
20/20
30/29
40/17
17/25/34/38
66/14/15/9
88/0/0/0
NA
NA
76/4/0/0
NA
NA
15/20/40/15
NA
40/29/93/18
1/1/7/4
11(I-II)/19(III-IV)
8/13/4/5
NA/NA
65.6(38-94)/NA
NA/NA
NA/43
NA/(28-43)
56.7/58.9
63.7(44-85)/29.94(18-69)
67.9/68.4
46.2±10.6/46.1±11.9
60.2(27-80)/59.1(23-80)
58.1/58.9
60.9/NA
58(36-84) /46
65.3±9.7/NA
10-Jul
2/1/3/1
52/15
56/30
9(I-II)/12/31
NA
RT-qPCR
RT-qPCR
TLDA/RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-PCR
Microarray
Microarray / RTqPCR
RT-qPCR
RT-qPCR
70/70
12/11/36/11
RT-qPCR
54 (30–77)/51(26–75)
68/68
NA
RT-qPCR
60.4±7.5/60.3±7.5
16(I-II)/37(III-IV)
29/56/48/23
NA
RT-qPCR
RT-qPCR
RT-PCR
NA/NA
60.2 ± 10.2/60.0 ± 10.4
62.3±9.8/NA
69/30
38/13/14/4
RT-qPCR
NA/NA
182/24
NA
RT-qPCR
67±10.4/64±12.9
113/89
19/43/38/13
RT-qPCR
55±7.6/57±10.4
49/49
65/70
0/42/7/0
NA
RT-qPCR
RT-qPCR
61.1±12.7/61.7±12.6
NA/NA
88/11
20/20/36/12
Microarray
52.9±7.8/51.0±9.2
101/19
27/20/42/12
Microarray
53/20
164/127
41/27
/
RT-
56.3±12.7/53.7±9.8
65.9 (42–85)/65.3(49-74)
NA/NA
(35-70)/(35-65)
qPCR
Wang 2014,(30)
China
CRC
Plasma
Up
Down
Down
Yong 2013,(31)
Malaysia
CRC
Blood
Up
miR-409-3p
miR-7, -93, -345, -25, -331-3p
miR-1274b, -130a*, -3122, -4267, -520a-3p, 548u, -92a-2*, -150, -342-3p
miR-122, -122* -1245, -18b*, -2116*, -296-5p, 3183, -409-5p, -513a-3p, -587
77/84
NA
112/50
25/32/31/24
Spain
CRC
Serum
Up
Luo 2013,(33)
Germany
CRC
Plasma
Up
Giráldez 2013,(34)
Spain
CRC
Plasma
Up
Kanaan 2013,(35)
USA
CRC
Plasma
Up
Greenberg 2013,(36)
Israel
CRC
Serum
Liu 2013,(37)
Toiyama 2013,(38)
Zhang 2013,(39)
Wang 2012,(14)
Wang 2012,(40)
Wang 2012,(41)
Kanaan 2012,(42)
Nugent 2012,(43)
Cheng 2011,(44)
Pu,2010,(45)
China
Japan
China
China
China
China
USA
Ireland
USA
China
CRC
CRC
CRC
CRC
CRC
CRC
CRC
CRC
CRC
CRC
Serum
Serum
Plasma
Serum
Serum
Plasma
Plasma
WB
Plasma
Plasma
Heneghan 2010,(46)
Ireland
CRC
Plasma
Huang 2010,(47)
China
CRC
Plasma
CRC
Plasma
Up
Zhang 2014,(49)
Hong
Kong
China
HCC
Serum
Giray 2014,(50)
Turkey
HCC
Plasma
Chiu 2013,(51)
Xie 2014,(52)
Shen 2013,(53)
Fu 2013,(54)
HCC
HCC
HCC
HCC
Serum
Serum
Plasma
Serum
HCC
Serum
Up
Tomimaru 2012,(56)
Taiwan
China
USA
China
Hong
Kong
Japan
Up
Up
Down
Up
Down
Up
Up
HCC
Plasma
Qi 2011,(57)
China
HCC
Serum
Up
Up
Down
Ng 2009,(48)
Hepatocellular cancer
Down
Up
Up
Up
Up
Up
Up
Down
Up
Down
Down
Up
Down
Up
Up
Down
Liu 2012,(55)
64/44
Microarray
64.4±9.0/61.5±9.3
30/26
0/0/30/0
Microarray
PCR
RT-qPCR
80/114
22/25/26/5
RT-qPCR
68.0±10.4/62.5±7.5
42/53
8/13/16/5
RT-qPCR
62.8/62.1
45/26
3/12/15/15
RT-qPCR
61.2(31-86)/60(29-85)
20/20
NA
RT-qPCR
55.5(24-70)/NA
200/80
186/53
78/86
32/29
114/0
90/58
30/30
63/45
74/28
103/37
18/96/64/22
45/57/43/41
36(I-II)/42(III-IV)
19(I-II)/13(III-IV)
0/27/70/20
26/25/29/10
3/4/15/4
5/22/19/16
8/14/17/35
7/38/40/18
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
Microfluidic array
RT-qPCR
RT-qPCR
RT-qPCR
57.9 (20-89)/57.5(28-89)
67.5/64
61.4/60.3
63(45-80)/46
28-82
61(21-84)/56(36-85)
60(43-76)/60(42-78)
71.2(35-90)/53.4(27-89)
54.2/55.3
58(39-84)/32(17-77)
30/63
7/13/9/1
RT-qPCR
68.8(45-88)/52.1(24-80)
100/59
27/25/38/10
RT-qPCR
61(26–84)/56(27–81)
miR-17-3p, -92
130/75
6/35/39/50
RT-qPCR
71(42–91)/69(45–85)
miR-143, -215
miR-125b-5p, -92a-3p, -122-5p
miR-223-3p
miR-130b
miR-101
miR-483-5p
miR-101
95/127
37/29/16/3
RT-qPCR
54.21±6.95/52.58±6.98
20/28
NA
RT-qPCR
60.4±2.57/49.58±2.002
20-Jun
67/30
49/49
25/20
NA
42/6/19(III-IV)
19(I-II)/30(III-IV)
6/14/5/0
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
NA/NA
51.69/37.26
61.1±11.7/61.5±11.0
NA/NA
miR-15b, -130b, -21, -183
57/59
45(I-II)/11(III-IV)
RT-qPCR
NA/NA
miR-21
miR-122, -222, -223
miR-21
126/50
67/16/43/0
RT-qPCR
63±10/62±8
70/34
8/36/20/6
RT-qPCR
49/38
miR-338-5p, -23b, -483-3p, -193a-3p, -23a
Brunet 2013,(32)
RT-qPCR
miR-18a, -29a
miR-145, -18a, -20a, -21, -29a, -92a, -106b, 133a, -143
miR-18a, -19a, -19b, -15b, -29a, -335
miR-25, -192, -431, -15b, -139-3p, -21, -331, 423-5p, -339-3p, -142-3p
miR-29c
miR-324-3p
miR-92a, -21
miR-21
miR-200c, -18a
miR-21
miR-29a
miR-601, -760
miR-21
miR-34a
miR-92
miR-221
miR-10b, -145, -155
let-7a
miR-29a, -92a
miR-25
/
RT68.1±11/64.1±7.4
Gui 2011,(58)
Xu 2011,(59)
Qu 2011,(60)
China
China
USA
HCC
HCC
HCC
Serum
Serum
Serum
Zhou 2011,(61)
China
HCC
Plasma
Up
Up
Down
Up
Down
Down
Ganepola,2014,(62)
USA
PCC
Plasma
Lung cancer
Pancreatic cancer
Up
miR-885-5p
miR-21, -122, -223
miR-195, -16, -199a
miR-194, -23b, -122, -192, -21, -801
miR-26a, -27a, -223
miR-486-5p, -18b, -1288, -486-3p, -18a, -7, 26b, -646, -1295, -301a, -106b, let-7i, -16, -20b,
-93, -106a, -17, -19b, -1468, -29b, -15b, -186, 10b, -143, -181a, -222, -221, -210, -21
miR-3184, -1909, -3154, -711, -3125, -4253, 762, -3188, -194, -193b
Up
miR-642b, -885-5p, -22
miR-196a, -196b
miR-21, -483-3p
miR-205, -210, -492, -1427
miR-744*, -1290, -628-3p, -550, -1825, -24, 134, -146a, -200c, -378, -484, -625, -22, -210
miR-221
miR-27a-3p, -16-5p, -15-5p
miR-375, -141, -548b-5p, -513a-3p
miR-222, -92a, -221
miR-20a, -21, -24, -25, -99a, -185, -191
miR-210, -16, -21, -155, -181a, -181b, -196a
miR-100a, -10
miR-18a
miR-200a, -200b
miR-21, -210, -155, -196a
Slater 2014,(63)
Abue 2014,(64)
Wang 2014,(30)
Germany
Japan
USA
PCC
PCC
PCC
Serum
Plasma
PJ
Up
Up
Up
Li 2013,(31)
USA
PCC
Serum
Up
Kawaguchi 2013,(65)
Frampton 2013,(66)
Japan
UK
PCC
PCC
Plasma
PBMC
Carlsen 2013,(67)
Denmark
PCC
Plasma
Liu R 2012,(68)
Liu J 2012,(69)
LaConti 2011,(70)
Morimura 2011,(71)
Li 2010,(72)
Wang 2009,(73)
China
China
USA
Japan
USA
USA
Serum
Plasma
Plasma
Plasma
Serum
Plasma
Krysan2014,(74)
USA
Plasma
Up
Shin 2014,(75)
Korea
PE
Yu 2014,(76)
China
Plasma
Franchina2014,(77)
Italy
PCC
PCC
PCC
PCC
PCC
PCC
NSCL
C
LADC
NSCL
C
NSCL
C
NSCL
C
Up
Up
Up
Down
Up
Up
Up
Up
Up
Up
46/24
101/89
105/71
NA
NA
NA
204/68
NA
RT-qPCR
RT-qPCR
RT-qPCR
Microarray
qPCR
11-Aug
NA
54.2/50.6
NA/NA
55(25-80)/NA
/
RT-
53/44
Microarray
64 (57-65)/46 (42-49)
Microarray
qPCR
RT-qPCR
RT-qPCR
RT-qPCR
Microarray
PCR
RT-qPCR
RT-qPCR
/
RT-
11-Nov
NA
19/10
32/30
50/19
2/7/0/10
1/8/10/13
NA
41/19
6/28/7/0
47/30
129/60
NA
NA
48/47
6/21/2021
RT-qPCR
65.49/59.53
95/81
138/68
8-Jun
36/30
45/32
49/36
NA
27/39/17/55
1/5/0/0
1/20/0/8
NA
NA
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-PCR
RT-qPCR
62.57/58.39
61.8/60.5
68.0/50.9
68(42-84)/NA
64.4 ± 10.0/44.3 ± 10.2
NA/NA
NA/(25-50)
70.6(48-89)/74.6(61-89)
NA/NA
/
RT-
65.2±10.1/43.8±11.5
67(42-84)/NA
NA/NA
miR-17, -18a, -19a, -19b, -20a, -92a
30/30
NA
Sequencing
NA/NA
Down
miR-134, -185, -22
45/42
NA
RT-qPCR
68 (33-92)/61 (22-92)
Down
miR-375
30/42/58/34
RT-qPCR
58.02±9.75/58.89±9.32
0/0/6/16
RT-qPCR
63(46-78)/NA
34(I-II)/118(III-IV)
RT-qPCR
NA/NA
60/35
NA
RT-qPCR
69.8/66.4
40/40
10/10/10/10
RT-qPCR
65.5/64.2
WB
Up
Serum
Down
Up
LC
Plasma
Up
miR-22, -24, -34a
164/164
22/27
Yang 2014,(78)
China
Cazzoli 2013,(79)
Italy
Rani 2013,(80)
Ireland
LADC
Serum
Up
Down
miR-152, -148a, -148b
miR-21
miR-378a, -379, -139-5p, -200b-5p, -151a-5p, 1974, -376a-5p, -30a-3p, -154-3p, -190b, -5025p, -629, -17, -100
miR-30c-1*, -616*, -146b-3p, -566, -550, -939
miR-339-5p, -656
Han,2013(81)
South
Korea
LADC
PE
Down
miR-198
45/42
NA
Abd-ElFattah2013,(82)
Egypt
LC
Serum
Up
miR-21, -155, -182, -197
65/37
NA
152/300
Microarray
qPCR
Microarray
qPCR
/
RT-
/
RT-
68(33-92)/61(22-92)
54.1±12.8/50.1±14.2
Breast cancer
Down
miR-10a
miR-21, -30e-5p
miR-21
miR-21,-155
miR-145
miR-942, -630, -190b, -144, let-7f, -15a, -20a, 18a, -1976, -93, -20b, -320c, -17, -652, -18b
miR-1284, -720, -1290
Serum
Down
miR-625*, -361-3p
97/30
NA
RT-qPCR
65(37-84)/40(21-66)
Serum
Up
miR-21, -205, -30d, -24
82/50
45/37(II-IV)
RT-qPCR
59/NA
Serum
Up
miR-125b
193/110
24/52/54/63
RT-qPCR
NA/NA
220/220
180/40/0/0
RT-qPCR
67.5(37-88)/67.7(33-86)
200/110
60/28/82/30
RT-qPCR
59.5±10.3/58.7±8.2
Markou2013,(83)
Greece
Wang2012,(14)
China
NSCL
C
LC
Tang,2013,(84)
China
LC
Plasma
Patnaik2012,(85)
USA
LADC
WB
Roth2012,(86)
Germany
Le 2012,(87)
China
Ma 2012,(88)
China
Heegaard,2012,(89)
USA
Chen 2012,(90)
China
Hennessey 2012,(91)
USA
Silva 2011,(92)
Spain
Roth 2011,(93)
Zheng 2011,(94)
Germany
USA
Wei 2011,(95)
China
NSCL
C
NSCL
C
NSCL
C
NSCL
C
NSCL
C
NSCL
C
NSCL
C
LC
LC
NSCL
C
NSCL
C
LC
LC
NSCL
C
NSCL
C
NSCL
C
BC
Plasma
Serum
Serum
Down
Up
Up
Up
Down
Up
Down
Up
Serum
Up
Serum
Up
Plasma
Down
Serum
Plasma
Plasma
miR-146b, -221, let-7a, -155, -17-5p, -27a, 106a
miR-29c
miR-20a, -24, -25, -145, -152, -199a-5p, -221, 222, -223, -320
37/28
NA
RT-qPCR
NA/NA
31/29
4(I-II)/27(III-IV)
RT-qPCR
61(47-78)/46
62/60
21/16/25/0
RT-qPCR
64.8/66
22/23
14/2/6/0
Microarray
70.6(50-85)/59.9(36-74)
miR-27b, -15b
55/75
33/13/7/2
RT-qPCR
68.2(48–85)/65.7(38–85)
let-7f, miR-20b, -30e-3p
78/48
NA
RT-qPCR
NA
Up
Up
miR-10b, -34a, -141, -155
miR-21, -128, -183, -155, -197, -182
35/28
6-Jun
NA
NA
RT-qPCR
RT-qPCR
55(32-71)/42(21-67)
NA
Up
miR-21
63/30
18/5/5/35
RT-qPCR
61(36-83)/57(41-75)
32/29
11/8/13(III-IV)
RT-qPCR
66.2/66.5
20/10
28/19
4/4/8/4
NA
RT-qPCR
Microarray
NA/NA
NA/NA
PB
PB
Up
Down
Up
Up
miR-21, -210
miR-486-5p
miR-21
let-7d, miR-328, -93*, -675
WB
Down
let-7a
35/30
5/1/16/13
RT-qPCR
67(48-84)/60(37-80)
Plasma
Up
Down
miR-21, -182, -210
miR-126, -486-5p
58/29
15/15/12/16
RT-qPCR
67.8/66
Serum
Up
miR-1254, -574-5p
22/31
6/14/0/0
RT-qPCR
62 (52–77)/62 (39–91)
Serum
Up
Up
Down
miR-24
miR-15a, -18a, -107, -425
miR-133a, -139-5p, -143, -145, -365
miR-186, -425, -454, -140-3p, let-7b, -483-5p, 155, -126, -146b-5p, -320, -191, -342-3p
miR-195, -486-5p, -484, -222, -574-3p, -29a
63/21
NA
RT-qPCR
58/NA
48/24
NA
RT-qPCR
58/57
miR-138
83/83
25/46/12/0
miR-29a, -181a, -223, -652
44/46
15/14/8/2
Shen(a)2011,(96)
China
Li 2011,(97)
Leidinger 2011,(98)
China
Germany
Jeong 2011,(99)
Korea
Shen(b)2010,(100)
USA
Foss 2011,(101)
USA
Sochor 2014,(102)
Czech
Kodahl 2014,(103)
Denmark
BC
Serum
Zearo 2014,(104)
Australia
BC
Serum
Plasma
Up
Waters 2014,(105)
Ireland
BC
Blood
Up
McDermott
UK
BC
Blood
Down
39/10
NA
98/25
TLDA
TLDA / RT-qPCR
Microarray / RTqPCR
RT-qPCR
58±16/60±6
57.2/57.1
59.86/44.21
2014,(106)
miR-454*, -222, -125b-2*, -1268, -200c, -15b*,
-181a-2*, -10a, -654-3p, -139-3p, -708
miR-30a, -144, -571, -93*, -487b, -1274b, 1274a, -212, -886-3p, -145, -1290, -1308, -1382*
5-Nov
NA
Up
miR-1280, -1260, -720
232/40
NA
Down
Park 2014,(107)
South
Korea
BC
WB
Up
Microarray
NA/NA
USA
Germany
Germany
Switzerla
nd
BC
BC
BC
Serum
Serum
Serum
Up
Up
Up
miR-148b, -133a
miR-373, -21, -210
miR-101, -372, -373
50/50
127/19
168/28
50(I-II)/0/0
NA
NA
Microarray
qPCR
RT-qPCR
RT-qPCR
RT-qPCR
BC
Plasma
Up
miR-373, -10b
10-Oct
NA
RT-qPCR
NA/NA
Mar-Aguilar
2013,(112)
Mexico
BC
Serum
Up
miR-10b, -21, -125b, -145, -155, -191, -382
61/10
13/14/34/0
RT-qPCR
(40-77)/NA
Cuk 2013,(113)
Germany
BC
Plasma
Up
120/60
39/55/22/2
RT-qPCR
48.6(30-77)/46.5(29-77)
Chan 2013,(114)
Singapor
e
BC
Serum
32/22
NA
RT-qPCR
50±13/47±6
Wang 2013,(115)
Zeng 2013,(116)
China
China
BC
BC
Serum
Plasma
46/58
100/64
NA
45/32/10/7
48.3(30-79)/52.0
51.4(30-84)/48.9(20-72)
Ng 2013,(117)
Hong
Kong
BC
Plasma
185/145
50/61/27/5
RT-qPCR
RT-qPCR
Microarray
Microarray
qPCR
Si 2013,(118)
China
BC
Serum
100/20
NA
RT-qPCR
NA/NA
Liu 2013,(119)
China
BC
Serum
20/10
3/10/7/0
RT-qPCR
NA/NA
Gao 2013,(120)
Wang 2012,(14)
Sun 2012,(121)
Jung 2012,(122)
van Schooneveld
2012,(123)
Schwarzenbach
2012,(124)
Wang 2012,(125)
Nugent 2012,(43)
China
China
China
USA
BC
BC
BC
BC
89/55
50/29
103/55
27/28
21/28/9/31
48(I-II)/2(III-IV)
29/36/30/8
NA
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
56(29-80)/50(28-65)
53(28–89)/46
53 (21-79)/51 (36-78)
52(21-70)/53.5(22-71)
Belgium
Shen 2014,(108)
Müller 2014,(109)
Eichelser 2014,(110)
Chen 2013,(111)
/
RT-
NA/NA
NA/NA
NA/NA
59(30-85)/NA
Serum
Serum
Serum
Plasma
Down
Up
Down
Up
Up
Down
Down
Up
Down
Up
Up
Up
Up
Up
miR-801, -127-3p, -376a, -652, -148b, -376c, 409-3p
let-7i,et-7b,miR-1, -133b, -133a, -92a, -10b, 486-5p, -423-5p, -7, -20a, -185, -16, -214, l, 144, -16-2*, -320a, -93
miR-223, -338-3p
miR-182
miR-30a
miR-27a, -150, -191, -200c, -210
miR-16, -21, -451
miR-145
miR-92a
miR-21
miR-205
miR-155
miR-21
miR-21
miR-155
miR-210, -21, -126, -29a
BC
Serum
Down
miR-411, -299-5p
75/20
19/14/22/20
RT-qPCR
NA/NA
Germany
BC
Serum
Up
miR-20a, -21, -214
102/53
NA
RT-qPCR
60(30-82)/50(20-79)
China
Ireland
BC
BC
Serum
WB
Up
Down
56/10
19/45
0/35/21/0
1/12/4/1
RT-qPCR
RT-qPCR
55(36-78)/NA
58(48-79)/53.4(27-89)
Schrauder 2012,(126)
Germany
BC
WB
Up
48/57
NA
Microarray
62 (34-89)/58
Guo 2012,(127)
China
BC
Serum
Down
miR-125b, -155, -10b
miR-34a
miR-4306, -425, -1323, -335, -497, -106b, -922,
-516b, -202, let-7a*
miR-718, -625*, -1471, -193a-3p, -182, -1915, 564, -107, -2355, -3186-3p, -24, -3130-3p, 526a, -1469, -874
miR-181a
152/75
40/79/13/16
RT-qPCR
50.38(25-83)/48.4(22-60)
Up
/
RT-
60(36-84)/61(40-85)
Cervical
cancer
Prostate cancer
Hu 2012,(128)
Wu 2012,(129)
Zhao 2012,(130)
Asaga 2011,(131)
Heneghan 2010,(46)
Roth 2010,(132)
China
China
China
USA
Ireland
Germany
BC
BC
BC
BC
BC
BC
Serum
Serum
Serum
Serum
Plasma
Serum
Up
Up
Up
Up
Up
Up
Zhao 2010,(133)
USA
BC
Plasma
Up
Chen 2013,(134)
China
CC
Serum
Up
Zhao 2013,(135)
Yu 2012,(136)
Li 2014,(137)
Wang 2014,(138)
Farina 2014,(139)
China
China
China
China
USA
CC
CC
CC
CC
PC
Serum
Serum
Serum
Serum
Serum
Cheng 2013,(140)
USA
PC
Serum
Up
Down
Down
Up
Up
Up
Down
Up
Up
Down
Up
Up
Nguyen 2013,(141)
USA
PC
Serum
Selth 2012,(142)
Shen 2012,(143)
Australia
USA
PC
PC
Serum
Plasma
Bryant 2012,(144)
USA
PC
Plasma
Chen 2012,(145)
China
PC
Plasma
Heneghan 2012,(46)
Ireland
PC
Plasma
Gonzales 2011,(146)
Brase 2011,(147)
Mitchell 2008,(148)
USA
USA
USA
PC
PC
PC
Plasma
Plasma
Serum
Up
Down
Down
Up
Down
Up
Up
Up
Up
miR-16, -25, -222, -324-3p
miR-222
miR-10b
miR-21
miR-195, let-7a
miR-155, -10b, -34a
miR-595, -589, -504, -518b, -483-5p, -425*, 493, -187, -431*, -1231
miR-668, -377, -410, -922, -155, -340*, -432, 574-3p, -148a, -181a, -1275, -1304, -151-5p
miR-1246, -20a, -2392, -3147, -3162-5p, -4484,
-4667-5p
miR-20a, -203
miR-218
miR-1, -2
miR-646
miR-21-5p, -93-5p
miR-100, -148a, -425-5p
miR-222
miR-141, -200a, -200c, -210, -375
miR-375,-378*,-141
miR-409-3p
miR-375, -141, -298, -346
miR-20a, -21, -145
miR-107, -130b, -141, -2110, -301a, -326, -3313p, -432, -484, -574-3p, -625*
miR-181a-2*
let-7e, let-7c, -30c
miR-1285, -622
miR-145, -155
let-7a
miR-141
miR-375, -141
miR-141, -100, -125b, -143, -296
76/76
50/50
122/59
102/20
83/63
89/29
24/36/16/0
50(I-II)
22/48/20/22
31/26/22/23
14/35/18/6
NA
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
52.99/49.16
55/53
52(26-77)/50(28-72)
NA/NA
55.1(30-88)/52.1(24-80)
56(31-82)/NA
20/20
20(I-II)
Microarray
56/57
40/20
NA
RT-qPCR
NA/NA
80/20
90/50
112/85
15-Oct
6-Oct
0/80(I-II/0/0)
62/18/6/4
NA
0/9/1/0/0
NA
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
RT-qPCR
49(25-69)/45(33-57)
51.0(36-70)/NA
47.86/NA
51(34-78)/28.8(24-34)
NA/NA
25/25
NA
TLDA
NA/NA
TLDA / RT-qPCR
84/0
NR
RT-qPCR
60 (53–69)
25/25
82/0
NA
0/82(Ⅱ-Ⅲ)/0
RT-qPCR
RT-qPCR
73.5(45-86)/NA
61.2
78/28
NA
RT-qPCR
70/63
80/54
NA
RT-qPCR
73(57-94)/73(54-84)
20/63
1/10/9/0
RT-qPCR
60.6(50-68)/52.1(24-80)
21/0
137/0
25/25
NR
NR
NA
RT-qPCR
TLDA and RT-qPCR
RT-qPCR
60-77
63.1
NA/NA
Abbreviations: NSCLC, Non-small cell lung cancer; LADC, Lung adenocarcinoma; LC, Lung cancer; HCC, Hepatocellular cancer; GC, Gastric cancer; PCC, Pancreatic cancer; CRC, Colorectal
cancer; PC, Prostate cancer; BC, Breast cancer; CC,Cervical cancer; NA, not available; PE, Pleural effusion; WB, Whole blood; PJ, Pancreatic juice; PBMC,peripheral blood mononuclear cell;
PB, peripheral blood; TLDA, TaqMan low density arrays.
Supplemental Figure 1. Number of patients involved in each sample type (A) and number of
dysregulated miRNA identified in each cancer type (B).
A)
B)
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69.
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72.
73.
74.
75.
76.
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
88.
89.
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