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CHIRAL PRIMARY, SECONDARY AND TERTIARY AMINES AS ORGANOCATALYSTS IN ASYMMETRIC CASCADE REACTIONS Dr. Carlos Arróniz The field of organocatalysis has evolved rapidly in the last decade and the use of chiral amines as catalysts has become a powerful strategy in stereoselective synthesis. The seminar will present asymmetric multi-step reactions promoted by chiral amines. The first part of the talk will focus on the ability of primary amino alcohols to perform a domino Michael-aldol reaction via iminium and enamine activation.1 The seminar will then move on to the cooperative catalysis between chiral amines and transition metals in multicatalytic cascades sequences. In particular, this second part will be centred on the combination of iminium, enamine and Lewis acid catalysis for a carbocyclization of aldehydes with alkynes;2 and on the combination of ammonium and Lewis acid catalysis for a formal [3+2] cycloaddition reaction.3 Multicatalytic Cascade Sequences Org. Biomol. Chem. 2011, 9, 5079–5085. 2 Chem. Eur. J. 2010, 16, 1750–1753. 3 Eur. J. Org. Chem. 2011, 3755–3760.