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Transcript
Lithium 3/11/10 PY Drug Book PY Mindmaps Class – mood stabiliser Mechanism of Action - element of the alkali metal group exact mechanism of action in mania is unknown ? alters Na+ transport in muscle and nerves cells ? alters intraneuronal metabolism of catecholamines Pharmaceutics - oral tablet - available in controlled released formulation Dose - 250-1200mg in divided doses - BD for controlled released Indications - bipolar disorder Adverse Effects - toxicity (see document on lithium toxicity) - interactions: haloperidol -> encephalopathic syndrome, neuromuscular blockers -> prolonged effect, ACE, diuretics and NSAIDS -> predispose to toxicity - nephrogenic diabetes insipidus - dehydration from decreased Na+ reabsorption in renal tubules - pseudotumour cerebri (increased ICP and papilloedema) PK Absorption – bioavability = > 90% Distribution – Vd 1L/kg Metabolism – nil Elimination – t1/2 = 12-24 hrs depending on whether chronic therapy, renal Evidence Jeremy Fernando (2011)
