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Tools to Maximize a
National Investment
in the GeneXpert
July 22, 2013
There Are Four Stable, Scaling-up
Data Services Around the GeneXpert
 GxAlert
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Open source, dev in 2012 by Abt Associates using their own money
Incorporates diagnostics for TB and flu (GeneXpert) and HIV (PIMA)
Active in India and Nigeria; early stage in 5 countries
 TBGxMonitor
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Developed in 2011 by Univ. of Witwatersand in South Africa
Active in South Africa; early stage in 13 countries
 XpertSMS
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Open source, dev in 2011 by IRD Pakistan under one-time grant
Active in Pakistan, Nepal, Kenya, Zimbabwe; early stage in 5 countries
The first three were
developed out of necessity…
teams just wanted the data.
It turns out, others wanted
the data too. So these
developed into software
products.
There is some overlap, but
generally each tool fits a
different set of needs.
 RemoteXpert
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Being developed now by Cepheid, estimated launch December 2013
Pilot tested in South Africa
Abt Associates
What Does Each Software Do?
Disease Management
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Case+Population level Management
Indicator reporting
MDR treatment
Drug demand / supply
Integration into existing National
Health Information Systems
 MOH messaging
 Clinic / lab messaging
 Patient messaging
Instrument Operations
Supply Chain Management
 Errors and error rate (by user,
module, and machine)
 External Quality Assurance (EQA)
 Instrument Verification
 Pre-analytical, analytical and
post-analytical evaluation
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Cartridge expirations
Stockout management
Utilization vs. disease load
Deployment planning
Procurement, warranty, and service
planning
Abt Associates
A Look Inside…GxAlert
Abt Associates
Each is Relatively Inexpensive to
Bring to National Scale

GxAlert ~$25,000 Yr1 to roll out nationwide and tech support existing
software; Yr2 ~$10,000

XpertSMS ~$25,000 Yr1 to roll out nationwide and tech support
existing software; Yr2 ~$10,000

TBGxMonitor available to complement NHLS/Wits DCS EQA
program. Independent use cost TBD.

Cepheid’s RemoteXpert, cost TBD, Dec 2013
By leveraging these tools, you can:
1)
2)
3)
Shorten diagnostic response time from months to
seconds, getting patients into treatment faster
Reduce waste, operating costs, and stockouts
Dramatically improve data quality
Organizations can pay for
customizations if desired, but
not necessary
Each of these software is
capable of communicating
with the others so installing a
mix of software is relatively
Abt Associates
easy and inexpensive
Why Include These Tools in Your
GeneXpert Implementation?
1.
Shorten diagnostic response time from months to seconds, getting
patients into treatment faster
2.
Reduce waste, operating costs, and stockouts
3.
Dramatically improve data quality
4.
Identify drug resistance patterns of TB strains
5.
Measure program adherence to the TB algorithms
6.
Order cartridges based on real-time demand forecasts
7.
…
Abt Associates
Better patient treatment
Faster response to MDR-TB
More efficient TB logistics
Prepared by:
Martha Benezet [email protected]
Jeff Takle [email protected]
Download slide deck @ www.GxAlert.com