Download Date of Document: March 24, 2017 CURRICULUM VITAE

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

Transcript
Date of Document: August 13, 2017
CURRICULUM VITAE
Muthusamy Kunnimalaiyaan PhD
Assistant Professor
Department of Surgery
Division of Surgical Oncology
OFFICE ADDRESS:
Translational and Biomedical Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-2840
Fax: 414-955-6059
Email: [email protected]
PLACE OF BIRTH: Kalugumalai, Tamil Nadu, India
CITIZENSHIP: U.S.A.
EDUCATION:
08/1980 - 07/1983 B.S., Madurai Kamaraj University, Madurai, TN
08/1983 - 08/1985 M.S., Madurai Kamaraj University, Madurai, TN
09/1987 - 02/1992 Ph.D., Indian Agricultural Research Institute, New Delhi, India
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1994 - 1996 Research Fellow, International Center for Genetic Engineering and Biotechnology, New Delhi,
India
1996 - 1997 Visiting Research Fellow, Auburn University, Auburn, Alabama
1997 - 2001 Research Assistant Professor/Research Associate, Department of Biology, Northern Illinois
University, DeKalb, Illinois
2001 - 2003 Assistant Scientist, Department of Surgery, Division of General Surgery, University of Wisconsin,
Madison, Wisconsin
2003 - 2007 Associate Scientist, Department of Surgery, Division of General Surgery, University of
Wisconsin, Madison, Wisconsin
2005 - 2012 Director, Endocrine Surgery Research Laboratories, Department of Surgery, University of
Wisconsin, Madison, Wisconsin
2007 - 2012 Senior Scientist, Department of Surgery, University of Wisconsin, Madison, Wisconsin
FACULTY APPOINTMENTS:
12/01/2012 - Present Assistant Professor, Department of Surgery, Division of Surgical Oncology, Medical
College of Wisconsin, and Milwaukee
AWARDS AND HONORS:
1992 Jawaharlal Nehru award (National Award) for outstanding Ph.D thesis, given by Indian Council of
Agricultural Research, India. [Single award was given for the entire Nation in the field of Plant
Physiology during 1992].
2004 Academic Staff Professional Development award, University of Wisconsin
2005 Robert Draper Technology Innovation award, University of Wisconsin
2006 Rising Star Award, North American Neuroendocrine Society
2007 Carcinoid Cancer Foundation Research Award, Carcinoid Cancer Foundation
2007 Wisconsin Alumni Research Foundation Lead discovery research initiative award, Wisconsin Alumni
Research Foundation
2009 Carcinoid Cancer Foundation Research award, Carcinoid Cancer Foundation
2012 Mirus Bio Research Award, Mirus
2016 Outstanding Poster presentation Award, Medical College of Wisconsin
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1985 - Present Association of Microbiologists of India (Life member)
1991 - 1993 Sigma Xi- Scientific Research Society (Past Member)
1992 - Present Society for plant Biochemistry and Biotechnology (Life member)
1993 - Present American Association for the Advancement of Science (Member)
2002 - Present American Association for Cancer Research, AACR- Active member (Member)
2004 - Present Association for Academic Surgery, AAS-Active member (Member)
2006 - 2012 European Neuroendocrine Tumor Society, ENETS- Member (Member)
2007 - Present North American Neuroendocrine Tumor Society, NANETS- Member (Member)
2010 - Present Association of Endocrine Surgeons- Member (Member)
2014 - Present Americas Hepatobiliary Pancreato-Biliary Association (Member)
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
2006 - 2008 International Journal of Cancer Research
2010 - 2012 Global Journal of Biochemistry
2013 - Present Science Letters
01/01/2015 - Present Hepatoma Research
2016 - Present World Journal of Gastrointestinal Surgery
2016 - Present PLoS ONE
Journal Review
2009 - Present Cancer Research
2009 - Present Molecular Cancer Therapeutics
2011 - Present Journal of Surgical Research
2014 - Present Cancer Cell International
2015 - Present Oncotargets and Therapy
2016 - Present Scientific Reports
2016 - Present Oncotarget
Ad-Hoc Reviewer
2015 - Present Journal of Experimental and Clinical Cancer Research
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
01/01/2014 - Present Member, Program Committee, Americas Hepatobiliary Pancreato Association
01/01/2015 - 12/30/2017 Member, Research Committee, Americas Hepatobiliary Pancreato Association
04/13/2015 - 04/12/2016 Teleconference Reviewer, Translational Team Science - Gastrointestinal Cancers - 1,
USAMRMC/CDMRP
05/01/2015 - 08/01/2015 Ad-hoc reviewer, ZRG1 EMNR D 55R (Special emphasis panel), NIH-CSR
2015 - Present Member, Research Affairs Committee, Medical College of Wisconsin
2016 Reviewer, Reviewer, St. Baldrick's Foundation
2016 - Present Study section-Member, Peer Reviewed Cancer Research Program- Liver Cancer, DODPRCRP-CDMRP
2016 - Present Member, Mentor Program, Medical College of Wisconsin
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2006 - 2007 Reviewer, Research grant, Star-fellowship- Singapore
2008 - Present Member and Reviewer, Travel Fellowship, Union for International Cancer Control
2009 - 2010 Thesis reviewer, Ph.D thesis, All Inida Institute of Medical Sciences, India
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Prior
Peer Review
Title:
Source:
Role:
Dates:
Direct Funds:
Determination of xanthohumol inhibits Notch signaling in vivo and increases
the survival and reduces tumor progression in HCC liver xenograft
Americas Hepato-pancreatic-biliary Association
Mentor
Muthusamy Kunnimalaiyaan
07/01/2016 - 06/30/2017
$30,000
Targeted inhibition and molecular profiling of neuroblastoma using
xanthohumol
St. Baldrick's Foundation
Mentor
Muthusamy Kunnimalaiyaan
07/01/2016 - 12/30/2016
$5,000
Travel Grant
University of Wisconsin
Principal Investigator
2004 - Present
$900
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Regulating Neuroendocrine Phenotype in Cancer
NIH/NCI
Co-Investigator
Herbert Chen
2006 - 2012
$710,000
Title:
Source:
Role:
Dates:
Identification of Notch activator using high throughput assayWisconsin Alumi Research Foundation
Principal Investigator
2006 - 2009
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Phase II clinical trial utilizing lithium for patients with neuroendocrine
tumors
NIH/NCI
Scientist
Herbert Chen
2007 - 2009
$342,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Combination of Raf-1 activation and Octreotide in Neuroendocrine cancer
Novartis
Co-Investigator
Herbert Chen
2008 - 2009
$54,000
Title:
Source:
Role:
Dates:
Direct Funds:
Pilot Studies on Pancreatic Cancer
University of Wisconsin
Principal Investigator
2008 - 2009
$25,000
Title:
Source:
Role:
Dates:
Direct Funds:
Pilot studies on targeting focal adhesion kinase in carcinoid
University of Wisconsin
Principal Investigator
2009 - 2010
$25,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
GSK-3 beta Signaling in Medullary Thyroid Cancer
NIH/NCI
Co-Investigator
Herbert Chen
2009 - 2014
$700,000
Title:
Source:
Role:
Dates:
Direct Funds:
Travel Grant
University of Wisconsin
Principal Investigator
2010 - Present
$900
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Role of GSK-3 in pancreatic cancer
NIH
Principal Investigator
Kunnimalaiyaan
07/01/2011 - 06/30/2013
$100,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Notch signalling in Medullary Thyroid Cancer
American Cancer Society
Co-Investigator
Herbert Chen
2011 - 2016
$1,000,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Signaling based therapy for HCC
Froedtert Hospital Foundation
Principal Investigator
Muthusamy Kunnimalaiyaan
01/01/2013 - 06/30/2014
$22,500
Title:
Source:
Role:
Interactions of Notch and GSK-3 proteins in pancreatic cancer
American Cancer Society Pilot Research Project Grant
Principal Investigator
PI:
Dates:
Direct Funds:
Muthusamy Kunnimalaiyaan
08/01/2013 - 07/31/2014
$30,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Role of Notch3 in HCC
Digestive Disease Center-MCW
Prinicpal Investigator
Muthusamy Kunnimalaiyaan
10/01/2013 - 09/30/2014
$12,000
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Role of ASCL1 in neuroblastoma
St. Baldrick's Foundation
Mentor
Muthusamy Kunnimalaiyaan
06/01/2015 - 12/30/2015
$5,000
Title:
Preclinical Studies on Pancreati Cancer
We Care Fund for Medical Innovation and Research Award-Department of
Surgery
Principal Investigator
Kunnimalaiyaan
09/01/2015 - 08/30/2016
$20,000
Source:
Role:
PI:
Dates:
Direct Funds:
Non-Peer Review
Title:
Source:
Role:
PI:
Dates:
Direct Funds:
Interaction of Notch1 and GSK-3 in Pancreatic cancer
Cancer Center
Principal Investigator
Muthusamy Kunnimalaiyaan
07/01/2014 - 06/30/2015
$20,000
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Conservation of Notch1 signaling in neuroendocrine tumors, Department of Surgery Research Forum,
Madison, WI, 2004
Role of MEK1 in carcinoids, Department of Surgery Research Forum, Madison, WI, 2009
Invited lecture, Department of Surgery Research Summit, Madison, WI, 2011
Exploring signaling based targeted therapy for Hepato-pancreato-Biliary cancers, Cancer Biology Research
Forum, Medical College of Wisconsin, Milwaukee, WI, 2014
Regional
Targeting Glycogen Synthase Kinase-3 beta in neuroendocrine cancers, La Crosse Bio research forum, La
Crosse, WI, 2011
Signaling based therapy for pancreatic cancer, Invited Lecture, UIC-Rockford, 10/14/2015
National
Carcinoid and neuroendocrine tumor Scientific Forum, New York, NY, 2011
International
Homologous yet compatible plasmids of Bacillius megaterium QM B1551, Invited lecture, Madurai Kamaraj
University, Madurai, TN, India, 2002
Session Chair, World Cancer Congress, Kerala, India, 2010
Signaling based therapy for carcinoids, Scientific Exchange group meeting, Gothenburg, Sweeden, 2012
PEER REVIEWED WORKSHOPS/PRESENTATIONS:
National
Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M, and Gamblin TC, Targeted inhibition of the AKT pathway
in cholangiocarcinoma via MK2206, American College of Surgeons, Washington, DC, 10/07/2013 10/09/2013
Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M, and Gamblin TC, MK2206, an Allosteric Akt Inhibitor,
Reduces Proliferation in Hepatocellular Carcinoma, Academic Surgical Congress, San Diego, CA,
02/04/2014 - 02/06/2014
Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M, and Gamblin TC, Targeted inhibition of the AKT pathway
in Cholangiocarcinoma by MK2206, an allosteric AKT inhibitor, America’s Hepato-Pancreato-Biliary
Association, Miami Beach, FL, 02/19/2014 - 02/23/2014
Koprowski ST, Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Curcumin-Mediated
Notch1 Signaling: A Potential Molecular Target in Cholangiocarcinoma, American College of Surgeons,
San Francisco, CA, 10/26/2014 - 10/30/2014
Balamurugan M, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Evaluating Glycogen Synthase
Kinase-3 as a Therapeutic target in Neuroblastoma, Academic Surgical Congress, Las Vegas, NV,
01/30/2015 - 02/01/2015
Koprowski S, Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Curcumin-mediated
regulation of Notch-1/HES-1/survivin pathway signaling: A potential target for cholangiocarcinoma,
Academic Surgical Congress, Las Vegas, NV, 01/30/2015 - 02/01/2015
Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, A flavonoid and midkine. Novel
targeted therapeutic approach for hepatocellular carcinoma, Academic Surgical Congress, Las Vegas,
NV, 01/30/2015 - 02/01/2015
Sokolowski K, Kunnimalaiyaan S, Wilson JM, Gamblin TC, and Kunnimalaiyaan M, Effect of MK-2206 on
Akt and Notch pathways in hepatocellular carcinoma, Society of Black Academic Surgeons, Chapel Hill,
NC, 04/09/2015 - 04/12/2015
Balamurugan M, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Xanthohumol induces apoptosis
and reduces Notch in neuroblastoma, American Association for Cancer Research, Philadelphia, PA,
04/18/2015 - 04/22/2015
1. Sokolowski K, Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M, An update of the role of glycogen
synthase kinase 3 in cholangiocarcinoma: Molecular profiling in an inducible knockdown system,
American Association for Cancer Research, Philadelphia, PA, 04/18/2015 - 04/22/2015
Walden, D, Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Xanthohumol, a hop
plant extract, decreases Notch1 and mediates cellular anti-carcinogenic pathways in cholangiocarcinoma
cell lines, American College of Surgeons, Chicago, IL, 10/04/2015 - 10/08/2015
Walden, D, Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Xanthohumol reduces
Notch1 and inhibits proliferation in cholangiocarcinoma, Academic Surgical Congress, Jacksonville, FL,
01/30/2016 - 02/01/2016
Erickson, S, Balamurugan, M, Kunnimalaiyaan, S, Gamblin, TC, and M. Kunnimalaiyaan, ASCL1 knockdown
suppresses neuroblastoma growth through induction of apoptosis, Academic Surgical Congress,
Jacksonville, FL, 01/30/2016 - 02/01/2016
Kunnimalaiyaan M, Kunnimalaiyaan S, Sokolowski K, and Gamblin TC, Effect of Vorinostat on Notch and
STAT3 pathway in hepatocellular carcinoma, Society of Black Academic Surgeons, Columbus, OH,
04/28/2016 - 04/30/2016
Engelsgjerd, S, Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M, Xanthohumol (XN) Increases Death
Receptor 5 Expression and Enhances Growth Suppression with the TNF-Related Apoptosis Inducing
Ligand (TRAIL) in Neuroblastoma Cell Lines, American College of Surgeons, Washington, DC,
10/16/2016 - 10/20/2016
Sokolowski K, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, LY2090314 suppresses
cholangiocarcinoma cell growth via apoptosis and associated with reduction in GSK-3, Academic
Surgical Congress, Las Vegas, NV, 02/06/2017 - 02/09/2017
Berger N, Ibrahim D, Kunnimalaiyaan S, Sokolowski K, Gamblin TC, and Kunnimalaiyaan M, HO-3867,
STAT3 Inhibitor, Effects on Cellular Proliferation in Hepatocellular Carcinoma., Americas HepatoPancreatico-Biliary Association, Miami Beach, FL, 03/29/2017 - 04/02/2017
Kunnimalaiyaan M, Sokolowski K, Kunnimalaiyaan S, and Gamblin TC, LY2090314, a novel agent for
potential treatment of Neuroblastoma, Society of Black Academic Surgeons, Chicago, IL, 04/27/2017 04/29/2017
Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Antiproliferative and apoptotic effect of LY2090314
in Neuroblastoma in vitro, Society of Asian Academic Surgeons, Birmingham AL, 09/21/2017 09/22/2017
International
Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M, and Gamblin TC, Targeted inhibition of the AKT pathway
in Cholangiocarcinoma by MK2206, an allosteric AKT inhibitor, International Hepato-Pancreato-Biliary
Association, Seoul Korea, 03/2014
Sokolowski K, Walden D, Kunnimalaiyaan S, Gamblin TC, and Kunnimalaiyaan M, Molecular profiling of
cholangiocarcinoma in an inducible Notch1 knockdown system., Americas Hepato-Pancreato-Biliary
Association International Conference, Sao Paulo, Brazil, 04/20/2016 - 04/23/2016
Kunnimalaiyaan M, Xanthohumol: A novel agent for the treatment of Pancreatic cancer, World Congress on
cancer research and therapy, San Diego, CA, 10/02/2017 - 10/04/2017
COMMITTEE SERVICE:
Medical College
2015 - Present Member, Research Affairs Committe, Medical College of Wisconsin
2016 - Present member, Mentor program, Medical College of Wisconsin
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Dahir Ibrahim, Medical College of Wisconsin, 05/25/2016 - 08/02/2016 Mentor
Medical Students
Jacob M Wilson, Medical College of Wisconsin, 06/01/2013 - 08/01/2013 Mentor, First place in the
Medical Student Summer Research Poster Competition at the Medical College of Wisconsin
Steven Koprowski, Medical College of Wisconsin, 06/01/2014 - 08/01/2014 Mentor, Two papers
published and received award
Daniel Walden, Medical College of Wisconsin, 06/01/2015 - 08/01/2015 Mentor
Stephen Erickson, Medical College of Wisconsin, 06/01/2015 - 08/01/2015 Mentor, St. Baldrick's Summer
Fellow Award
Samuel Engelsgjerd, Medical College of Wisconsin, 05/25/2016 - 08/12/2016 Mentor, St. Baldrick's
Summer Fellow award
Victoriana Schwartz, Medical College of Wisconsin, 2017 Mentor
Postdoctoral Students
Kevin Sokolowski, Medical College of Wisconsin, 12/01/2013 - 12/10/2016 Mentor, 5 papers published
and received various awards
Balamurugan Mariappan, Medical College of Wisconsin, 03/25/2014 - 08/01/2015 Mentor, 3 papers
published
Residents
Dr. Nicholas Berger, Medical College of Wisconsin, 07/01/2016 - 06/30/2017 Mentor, Received AHPBA
Research Award
BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Kunnimalaiyaan M, Lodha ML, Sreekumar KR. Integration ofhup cosmid pHU52 into the chromosomal DNA
ofCicer-Rhizobium using Tn5 as an homologous sequence. World J Microbiol Biotechnol. 1992 Nov;8(6):567-72.
2. Nag MK, Thai TT, Ruff EA, Selvamurugan N, Kunnimalaiyaan M, Eliceiri GL. Genes for E1, E2, and E3 small
nucleolar RNAs. Proc Natl Acad Sci U S A. 1993 Oct 01;90(19):9001-5. PMCID: PMC47489
3. Badran H, Venkatesh TV, Kunnimalaiyaan M, Sharma N, Das HK. Molecular characterization of the
Azotobacter vinelandii recF gene. Gene. 1995 Aug 30;162(1):47-51.
4. Lu Z, Kunnimalaiyaan M, Nielsen BL. Characterization of replication origins flanking the 23S rRNA gene in
tobacco chloroplast DNA. Plant Mol Biol. 1996 Nov;32(4):693-706.
5. Kunnimalaiyaan M, Shi F, Nielsen BL. Analysis of the tobacco chloroplast DNA replication origin (oriB)
downstream of the 23 S rRNA gene. J Mol Biol. 1997 May 02;268(2):273-83.
6. Kunnimalaiyaan M, Nielsen BL. Fine mapping of replication origins (ori A and ori B) in Nicotiana tabacum
chloroplast DNA. Nucleic Acids Res. 1997 Sep 15;25(18):3681-6. PMCID: PMC146947
7. Stevenson DM, Kunnimalaiyaan M, Müller K, Vary PS. Characterization of a theta plasmid replicon with
homology to all four large plasmids of Bacillus megaterium QM B1551. Plasmid. 1998 Nov;40(3):175-89.
8. Backert S, Kunnimalaiyaan M, Börner T, Nielsen BL. In vitro replication of mitochondrial plasmid mp1 from
the higher plant Chenopodium album (L.): a remnant of bacterial rolling circle and conjugative plasmids? J Mol
Biol. 1998 Dec 11;284(4):1005-15.
9. Kunnimalaiyaan M, Stevenson DM, Zhou Y, Vary PS. Analysis of the replicon region and identification of an
rRNA operon on pBM400 of Bacillus megaterium QM B1551. Mol Microbiol. 2001 Feb;39(4):1010-21.
10. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Lagerholm S, Chen H. Raf-1 activation suppresses
neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest
Liver Physiol. 2003 Aug;285(2):G245-54.
11. Scholle MD, White CA, Kunnimalaiyaan M, Vary PS. Sequencing and characterization of pBM400 from
Bacillus megaterium QM B1551. Appl Environ Microbiol. 2003 Nov;69(11):6888-98. PMCID: PMC262321
12. Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H. The role of human achaete-scute homolog-1 in
medullary thyroid cancer cells. Surgery. 2003 Dec;134(6):866-71; discussion 871-3.
13. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ,
Nelkin BD, Chen H, Ball DW. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor
cells by notch signaling. J Clin Endocrinol Metab. 2005 Jul;90(7):4350-6.
14. Musunuru S, Carpenter JE, Sippel RS, Kunnimalaiyaan M, Chen H. A mouse model of carcinoid syndrome and
heart disease. J Surg Res. 2005 Jun 01;126(1):102-5.
15. Kunnimalaiyaan M, Vary PS. Molecular characterization of plasmid pBM300 from Bacillus megaterium QM
B1551. Appl Environ Microbiol. 2005 Jun;71(6):3068-76. PMCID: PMC1151835
16. Van Gompel JJ, Kunnimalaiyaan M, Holen K, Chen H. ZM336372, a Raf-1 activator, suppresses growth and
neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther. 2005 Jun;4(6):910-7.
17. Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal
carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G636-42.
18. Kunnimalaiyaan M, Yan S, Wong F, Zhang YW, Chen H. Hairy Enhancer of Split-1 (HES-1), a Notch1
effector, inhibits the growth of carcinoid tumor cells. Surgery. 2005 Dec;138(6):1137-42; discussion 1142.
19. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. ZM336372, a Raf-1 activator, inhibits growth of
pheochromocytoma cells. J Surg Res. 2006 Jun 01;133(1):42-5.
20. Vaccaro A, Chen H, Kunnimalaiyaan M. In-vivo activation of Raf-1 inhibits tumor growth and development in
a xenograft model of human medullary thyroid cancer. Anticancer Drugs. 2006 Aug;17(7):849-53.
21. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Overexpression of the NOTCH1 intracellular domain
inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem.
2006 Dec 29;281(52):39819-30.
22. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by
the PI3K inhibitor LY294002. Surgery. 2006 Dec;140(6):1009-14; discussion 1014-5.
23. Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H. Lithium ions: a novel treatment for pheochromocytomas
and paragangliomas. Surgery. 2007 Feb;141(2):161-5; discussion 165. PMCID: PMC1945109
24. Greenblatt DY, Kunnimalaiyaan M, Chen H. Raf-1 activation in gastrointestinal carcinoid cells decreases
tumor cell adhesion. Am J Surg. 2007 Mar;193(3):331-5; discussion 335. PMCID: PMC1838566
25. Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H. Inactivation of glycogen synthase kinase-3beta, a
downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells.
Mol Cancer Ther. 2007 Mar;6(3):1151-8.
26. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. The HDAC inhibitor trichostatin A inhibits growth of
small cell lung cancer cells. J Surg Res. 2007 Oct;142(2):219-26.
27. Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, Chen H. Valproic acid
activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist. 2007
Aug;12(8):942-51.
28. Greenblatt DY, Cayo M, Ning L, Jaskula-Sztul R, Haymart M, Kunnimalaiyaan M, Chen H. Suberoyl
bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. J
Gastrointest Surg. 2007 Nov;11(11):1515-20; discussion 1520.
29. Kunnimalaiyaan M, Ndiaye M, Chen H. Neuroendocrine tumor cell growth inhibition by ZM336372 through
alterations in multiple signaling pathways. Surgery. 2007 Dec;142(6):959-64; discussion 959-64. PMCID:
PMC2180346
30. Deming D, Geiger P, Chen H, Vaccaro A, Kunnimalaiyaan M, Holen K. ZM336372, a Raf-1 activator, causes
suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008
May;12(5):852-7.
31. Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H. Suberoyl bis-hydroxamic acid activates Notch-1
signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist. 2008 Feb;13(2):98-104.
32. Sippel RS, Kunnimalaiyaan M, Chen H. Current management of medullary thyroid cancer. Oncologist. 2008
May;13(5):539-47.
33. Pinchot SN, Pitt SC, Sippel RS, Kunnimalaiyaan M, Chen H. Novel targets for the treatment and palliation of
gastrointestinal neuroendocrine tumors. Curr Opin Investig Drugs. 2008 Jun;9(6):576-82. PMCID: PMC2905744
34. Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H. Valproic acid
activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells. Ann Surg. 2008
Jun;247(6):1036-40. PMCID: PMC2904809
35. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H. Suberoyl bishydroxamic acid activates notch1 signaling
and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann Surg Oncol. 2008
Sep;15(9):2600-5. PMCID: PMC2737668
36. Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H. Valproic acid induces Notch1 signaling in small cell
lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7. PMCID: PMC2900385
37. Ning L, Kunnimalaiyaan M, Chen H. Regulation of cell-cell contact molecules and the metastatic phenotype of
medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway. Surgery. 2008 Dec;144(6):920-4; discussion 9245. PMCID: PMC2639554
38. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Histone deacetylase inhibitors upregulate Notch-1 and
inhibit growth in pheochromocytoma cells. Surgery. 2008 Dec;144(6):956-61; discussion 961-2. PMCID:
PMC2638099
39. Pinchot SN, Adler JT, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycin suppresses growth
and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am J Surg. 2009
Mar;197(3):313-9. PMCID: PMC2664746
40. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Combination therapy with histone deacetylase inhibitors
and lithium chloride: a novel treatment for carcinoid tumors. Ann Surg Oncol. 2009 Feb;16(2):481-6. PMCID:
PMC2740795
41. Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and
tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.
Mol Cancer Ther. 2009 Apr;8(4):914-20. PMCID: PMC2670470
42. Goodell CA, Belisle JA, Gubbels JA, Migneault M, Rancourt C, Connor J, Kunnimalaiyaan M, Kravitz R,
Tucker W, Zwick M, Patankar MS. Characterization of the tumor marker muc16 (ca125) expressed by murine
ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies. J Ovarian Res. 2009
Jun 18;2(1):8. PMCID: PMC2708168
43. Pitt SC, Chen H, Kunnimalaiyaan M. Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses
tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors. Ann Surg Oncol. 2009
Oct;16(10):2936-42. PMCID: PMC2917194
44. Pitt SC, Chen H, Kunnimalaiyaan M. Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells.
J Am Coll Surg. 2009 Jul;209(1):82-8. PMCID: PMC2910111
45. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of the PI3K pathway suppresses hormonal
secretion and limits growth in pheochromocytoma cells. World J Surg. 2009 Nov;33(11):2452-7. PMCID:
PMC3088764
46. Pitt SC, Davis R, Kunnimalaiyaan M, Chen H. AKT and PTEN expression in human gastrointestinal carcinoid
tumors. Am J Transl Res. 2009 Feb 28;1(3):291-9. PMCID: PMC2776321
47. Pinchot SN, Kunnimalaiyaan M, Sippel RS, Chen H. Medullary thyroid carcinoma: targeted therapies and
future directions. J Oncol. 2009;2009:183031. PMCID: PMC2798103
48. Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H. Inhibition of growth in medullary thyroid cancer cells
with histone deacetylase inhibitors and lithium chloride. J Surg Res. 2010 Apr;159(2):640-4. PMCID:
PMC2858235
49. Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. MG-132 inhibits carcinoid growth and alters the
neuroendocrine phenotype. J Surg Res. 2010 Jan;158(1):15-9. PMCID: PMC2795050
50. Deming D, Geiger P, Chen H, Kunnimalaiyaan M, Holen K. ZM336372 induces apoptosis associated with
phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res. 2010 Jun 01;161(1):28-32.
PMCID: PMC3379885
51. Rose SL, Kunnimalaiyaan M, Drenzek J, Seiler N. Notch 1 signaling is active in ovarian cancer. Gynecol
Oncol. 2010 Apr;117(1):130-3.
52. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol inhibits the neuroendocrine
transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in
medullary thyroid cancer. Am J Surg. 2010 Mar;199(3):315-8; discussion 318. PMCID: PMC2841322
53. Cook MR, Pinchot SN, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H. Identification of a novel Raf-1
pathway activator that inhibits gastrointestinal carcinoid cell growth. Mol Cancer Ther. 2010 Feb;9(2):429-37.
PMCID: PMC2820603
54. Chen JY, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. MG-132 inhibits carcinoid growth and alters the
neuroendocrine phenotype. J Surg Res. 2010 Jan;158(1):15-9. PMCID: PMC2795050
55. Cook MR, Luo J, Ndiaye M, Chen H, Kunnimalaiyaan M. Xanthohumol inhibits the neuroendocrine
transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in
medullary thyroid cancer. Am J Surg. 2010 Mar;199(3):315-8; discussion 318. PMCID: PMC2841322
56. Cook MR, Pinchot SN, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H. Identification of a novel Raf-1
pathway activator that inhibits gastrointestinal carcinoid cell growth. Mol Cancer Ther. 2010 Feb;9(2):429-37.
PMCID: PMC2820603
57. Ning L, Chen H, Kunnimalaiyaan M. Focal adhesion kinase, a downstream mediator of Raf-1 signaling,
suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells. Mol Cancer Res.
2010 May;8(5):775-82. PMCID: PMC2872724
58. Greenblatt DY, Ndiaye M, Chen H, Kunnimalaiyaan M. Lithium inhibits carcinoid cell growth in vitro. Am J
Transl Res. 2010 May 10;2(3):248-53. PMCID: PMC2892410
59. Alexander VM, Roy M, Steffens KA, Kunnimalaiyaan M, Chen H. Azacytidine induces cell cycle arrest and
suppression of neuroendocrine markers in carcinoids. Int J Clin Exp Med. 2010 Mar 28;3(2):95-102. PMCID:
PMC2894643
60. Meyer-Rochow GY, Jackson NE, Conaglen JV, Whittle DE, Kunnimalaiyaan M, Chen H, Westin G, Sandgren
J, Stålberg P, Khanafshar E, Shibru D, Duh QY, Clark OH, Kebebew E, Gill AJ, Clifton-Bligh R, Robinson BG,
Benn DE, Sidhu SB. MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic
and therapeutic targets. Endocr Relat Cancer. 2010 Sep;17(3):835-46.
61. Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. Resveratrol induces Notch2-mediated
apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011
May;18(5):1506-11. PMCID: PMC3078954
62. Zarebczan B, Pinchot SN, Kunnimalaiyaan M, Chen H. Hesperetin, a potential therapy for carcinoid cancer.
Am J Surg. 2011 Mar;201(3):329-32; discussion 333. PMCID: PMC3073682
63. Lubner SJ, Kunnimalaiyaan M, Holen KD, Ning L, Ndiaye M, Loconte NK, Mulkerin DL, Schelman WR,
Chen H. A preclinical and clinical study of lithium in low-grade neuroendocrine tumors. Oncologist.
2011;16(4):452-7. PMCID: PMC3119207
64. Pinchot SN, Jaskula-Sztul R, Ning L, Peters NR, Cook MR, Kunnimalaiyaan M, Chen H. Identification and
validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer.
2011 Apr 01;117(7):1386-98. PMCID: PMC3117093
65. Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M. Expression of the active Notch1
decreases MTC tumor growth in vivo. J Surg Res. 2011 Nov;171(1):23-7. PMCID: PMC3157562
66. Phan T, Yu XM, Kunnimalaiyaan M, Chen H. Antiproliferative effect of chrysin on anaplastic thyroid cancer. J
Surg Res. 2011 Sep;170(1):84-8. PMCID: PMC3154442
67. Xiao Y, Jaskula-Sztul R, Javadi A, Xu W, Eide J, Dammalapati A, Kunnimalaiyaan M, Chen H, Gong S. Codelivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer
therapy. Nanoscale. 2012 Nov 21;4(22):7185-93. PMCID: PMC3495135
68. Alhefdhi A, Burke JF, Redlich A, Kunnimalaiyaan M, Chen H. Leflunomide suppresses growth in human
medullary thyroid cancer cells. J Surg Res. 2013 Nov;185(1):212-6. PMCID: PMC3805832
69. Somnay Y, Simon K, Harrison AD, Kunnimalaiyaan S, Chen H, Kunnimalaiyaan M. Neuroendocrine
phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in
carcinoid cell lines in vitro. Anticancer Drugs. 2013 Jan;24(1):66-72. PMCID: PMC3510354
70. Yu XM, Jaskula-Sztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M, Chen H. Resveratrol induces
differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and
suppresses cell growth. Mol Cancer Ther. 2013 Jul;12(7):1276-87. PMCID: PMC3707971
71. Somnay Y, Chen H, Kunnimalaiyaan M. Synergistic effect of pasireotide and teriflunomide in carcinoids in
vitro. Neuroendocrinology. 2013;97(2):183-92. PMCID: PMC3546174
72. Burke JF, Schlosser L, Harrison AD, Kunnimalaiyaan M, Chen H. MK-2206 causes growth suppression and
reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. Ann Surg
Oncol. 2013 Nov;20(12):3862-8. PMCID: PMC3955957
73. Dilip A, Cheng G, Joseph J, Kunnimalaiyaan S, Kalyanaraman B, Kunnimalaiyaan M, Gamblin TC.
Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma.
Anticancer Drugs. 2013 Oct;24(9):881-8. PMCID: PMC4028966
74. Wilson JM, Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M. MK2206 inhibits hepatocellular carcinoma
cellular proliferation via induction of apoptosis and cell cycle arrest. J Surg Res. 2014 Oct;191(2):280-5.
75. Carter YM, Kunnimalaiyaan S, Chen H, Gamblin TC, Kunnimalaiyaan M. Specific glycogen synthase kinase-3
inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther. 2014
May;15(5):510-5. PMCID: PMC4026073
76. Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M, Gamblin TC. Inhibition of the AKT pathway in
cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis. Cancer Cell Int.
2015;15(1):13. PMCID: PMC4324843
77. Kunnimalaiyaan S, Trevino J, Tsai S, Gamblin TC, Kunnimalaiyaan M. Xanthohumol-Mediated Suppression
of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells. Mol Cancer Ther.
2015 Jun;14(6):1395-403. PMCID: PMC4554525
78. Koprowski S, Sokolowski K, Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M. Curcumin-mediated
regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma. J Surg
Res. 2015 Oct;198(2):434-40.
79. Kunnimalaiyaan S, Sokolowski KM, Balamurugan M, Gamblin TC, Kunnimalaiyaan M. Xanthohumol inhibits
Notch signaling and induces apoptosis in hepatocellular carcinoma. PLoS One. 2015;10(5):e0127464. PMCID:
PMC4444108
80. Kunnimalaiyaan S, Gamblin TC, Kunnimalaiyaan M. Glycogen synthase kinase-3 inhibitor AR-A014418
suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression. HPB (Oxford).
2015 Sep;17(9):770-6. PMCID: PMC4557650
81. Kunnimalaiyaan S, Sokolowski KM, Gamblin TC, Kunnimalaiyaan M. Suberoylanilide hydroxamic acid, a
histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines. Am J Surg.
2017 Apr;213(4):645-651. doi: 1016/j.amjsurg.2016.12.001. Epub 2016 Dec 11. PMID: 28007318
Books, Chapters, and Reviews
1. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary thyroid cancer: the functions of raf-1 and human
achaete-scute homologue-1. Thyroid. 2005 Jun;15(6):511-21.
2. Kunnimalaiyaan M, Chen H. The Raf-1 pathway: a molecular target for treatment of select neuroendocrine
tumors? Anticancer Drugs. 2006 Feb;17(2):139-42.
3. Kunnimalaiyaan M, Chen H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist.
2007 May;12(5):535-42.
4. Kunnimalaiyaan M, Haymart MR, Chen H. Tumor suppressor role of notch1 and raf-1 signaling in medullary
thyroid cancer cells. Transl Oncogenomics. 2007;2:43-7. PMCID: PMC3634621
5. Kevin M. Sokolowski, Mariappan Balamurugan, Selvi Kunnimalaiyaan, T. Clark Gamblin, Muthusamy
Kunnimalaiyaan. Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease.
Hepatoma Research. 2015 1:11-15
6. Sokolowski KM, Koprowski S, Kunnimalaiyaan S, Balamurugan M, Gamblin TC, Kunnimalaiyaan M. Potential
Molecular Targeted Therapeutics: Role of PI3-K/Akt/mTOR Inhibition in Cancer. Anticancer Agents Med Chem.
2016;16(1):29-37.
7. Sokolowski KM, Balamurugan M, Kunnimalaiyaan S, Wilson J, Gamblin TC, Kunnimalaiyaan M. Role of Akt
inhibition on Notch1 expression in hepatocellular carcinoma: potential role for dual targeted therapy. Am J Surg.
2016 Apr;211(4):755-60.
8. Somnay YR, Kunnimalaiyaan M. The Phosphatidylinositol 3-kinase/Akt Signaling Pathway in Neuroendocrine
Tumors. Glob J Biochem. 2012;3. PMCID: PMC5157925
9. Kunnimalaiyaan S, Sokolowski K, Gamblin TC, Kunnimalaiyaan M. Suberoylanilide hydroxamic Acid, a
histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines. Am J Surg.
2017 Apr;213(4):645-651.
Patents
1. Modulating Notch1 signaling pathway for treating neuroendocrine tumors. Inventors: Herbert Chen and
Muthusamy Kunnimalaiyaan Patent number US8,338,482 B2 (Dec 2012)
Similar