FOAD KABINEJADIAN Department of Biomedical Engineering, Tulane University, New Orleans [email protected] ; [email protected] ~ (734)780-4748 EDUCATION & CREDENTIALS Doctor of Philosophy in Mechanical Engineering NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, 2012 Master of Science in Biomedical Engineering (Biomechanics) IRAN UNIVERSITY OF SCIENCE AND TECHNOLOGY, Tehran, Iran, 2006 Bachelor of Science in Mechanical Engineering AMIRKABIR UNIVERSITY OF TECHNOLOGY, Tehran, Iran, 2003 PROFESSIONAL/RESEARCH EXPERIENCE Tulane University – New Orleans POSTDOCTORAL RESEARCH FELLOW, 1/2017 to present • Gas embolotherapy for treatment of hepatocellular carcinoma and renal carcinoma: − Conducting in vivo studies of gas embolotherapy in mice, including induction of tumor, followed by performing treatments utilizing acoustic droplet vaporization in the tumor to occlude blood flow and starve tumor. University of Michigan – Ann Arbor POSTDOCTORAL RESEARCH FELLOW, 12/2015 to 12/2016 • Gas embolotherapy for treatment of hepatocellular carcinoma and renal carcinoma: − Conducted in vivo studies of gas embolotherapy in mice, including induction of tumor, followed by performing treatments utilizing acoustic droplet vaporization in the tumor to occlude blood flow and starve tumor. − Theoretical modelling of gas micro-bubble formation and expansion due to acoustic droplet vaporization by ultrasound. National University of Singapore (NUS) – Singapore POSTDOCTORAL RESEARCH FELLOW, 4/2011 to 12/2015 Designed different novel medical devices in a number of projects funded by Agency for Science, Technology and Research (A*STAR), and by National Medical Research Council (NMRC), Singapore, at the Department of Biomedical Engineering and the Department of Surgery, NUS. Designed in vitro test methods and implemented experimental assessments. Conducted computational simulations for design optimizations. Fabricated prototypes and contributed to in vivo animal trials of the prototypes. Wrote four research grant proposals: Select projects… FOAD KABINEJADIAN Page 2 of 6 • Covered stent membrane design for treatment of atheroembolic diseases: − Designed a novel membrane for prevention of emboli and preservation of side-branch flows (PCT WO/2013/055293A1, 2013) for treatment of atheroembolic diseases, such as carotid artery stenosis and peripheral arterial diseases. − Fabricated PDMS replicas of realistic carotid artery geometries and designed and setup physiological flow loops. − Conducted Particle Image Velocimetry (PIV) to measure the flow field velocity. − Conducted in vitro evaluation of flow preservation through the novel covered stent. − Invented and made a novel ‘plaque analogue’ to mimic atherosclerotic plaques and conducted in vitro evaluation of emboli prevention by the novel covered stent. − Contributed to in vitro thrombogenicity test of the covered stent. − Contributed to in vivo animal trials of the covered stent in pig models. • An operative-adjunct device for maintaining visualization during laparoscopic surgery – Seymour Shield: − Designed two distinct devices based on different engineering concepts to address the problem. − Fabricated working prototypes. − Designed and conducted in vitro evaluations. • A Nasogastric Tube Insertion Guide – Soprano: This device is designed based on an acoustic negative feedback as well as having an anatomic geometric configuration for easier insertion to esophagus. − Designed and fabricated a variety of configurations for the device. − Fabricated PDMS replicas of realistic human respiratory and digestive tracts. − Designed and conducted in vitro evaluation of prototypes. • Development of a more accurate method for measurement of Mitral Regurgitation, utilizing ultrasound and computational fluid dynamics (CFD): Contributed essentially to the design and development of a novel method to considerably improve the accuracy of mitral regurgitation measurement by combining the patients’ ultrasound data with CFD simulations. − Performed computational reconstruction of patients’ mitral valve geometries. − Developed MATLAB codes to analyze the patients’ Doppler data to extract the patientspecific boundary conditions for the CFD simulations. − Conducted 3D CFD simulations to obtain accurate mitral regurgitation. − Designed an in vitro test method and fabricated the flow loop. − Conducted ultrasound measurements to validate the method. • Design, fabrication, and in vitro trials of different heart valves, including a percutaneous mitral valve, percutaneous cava valves, and tissue aortic valves: Contributed significantly to a number of projects on the design and testing of different heart valves. − Designed stents and fabricated stent valves. − Designed and fabricated test rigs and physiological flow loops. − Conducted flow measurement by Particle Image Velocimetry (PIV). − Contributed to animal trials of the valves. • A gastric device for treatment of Type II diabetes mellitus and obesity: Contributed to the design, assembly, and animal trials of the device. FOAD KABINEJADIAN Page 3 of 6 INDUSTRY CONSULTING EXPERIENCE Merlin Medical, PTE LTD – Singapore CONSULTANT, 6/2013 to 6/2014 As a Research Consultant, provided the following research services to this medical device (stent) manufacturer to obtain regulatory approval of their product: − Fabricated PDMS models of intracranial internal carotid artery with branches. − Performed in vitro testing, PIV flow measurements, and hemodynamic performance evaluation of their flow modulator covered stents for treatment of intracranial aneurysm. − Conducted computational simulations of blood flow through the porous membrane of the flow modulator covered stents in branched models of internal carotid artery. TEACHING/MENTORING EXPERIENCE Department of Biomedical Engineering, National University of Singapore (NUS), Singapore Mentor of Graduate and Undergraduate Students, 4/2011 to 12/2015 Mentored nine graduate research associates (including five PhD students) and a number of undergraduate Final-Year-Project students. Department of Mechanical and Engineering, Bangladesh University of Engineering & Technology (BUET), Dhaka, Bangladesh Invited Instructor, 6/2013 Conducted a workshop on “Experimental Biofluid Mechanics” and “Particle Image Velocimetry (PIV) Measurement Technique” as an invited instructor at Bangladesh University of Engineering and Technology (BUET). School of Mechanical and Aerospace Engineering, Nanyang Technological University (NTU), Singapore Teaching Assistant, 8/2007 to 11/2010 Taught undergraduate courses and laboratory sessions on “Thermodynamics” and “Heat Transfer” for seven consecutive semesters. RESEARCH GRANTS FUNDED Co-Investigator – S$500,000 (US$370,000), 9/2014 to 3/2016 “Prototype and Delivery System Optimization of a Novel Covered Stent for Treatment of Atheroembolic Arterial Disease”, Biomedical Engineering Programme (BEP), Agency for Science, Technology, and Research (A*STAR), Singapore. Collaborator – £192,000 (€240,000), 10/2014 to 3/2016 “Development of a Novel Flow Field Augmentation Technique to Improve the Patency of Distal Graft Anastomosis”, Engineering and Physical Sciences Research Council (EPSRC), UK. FOAD KABINEJADIAN Page 4 of 6 HONORS AND AWARDS Scholarships/Fellowships − − − Full Graduate Research Scholarship Award, Granted by Nanyang Technological University, Singapore, 1/2007 to 1/2011 Fully Subsidized Graduate Studies, Iran University of Science and Technology, Tehran, 9/2003 to 7/2006 Fully Subsidized Undergraduate Studies, Amirkabir University of Technology, Tehran, 9/1998 to 9/2003 Competition Awards − − First Prize Winner, “MIT HackMed @ SG”, the first MIT Hacking Medicine healthcare hackathon in Singapore, 7/2015 Thematic Prize Winner for best addressing the “Aging-in-Place” Challenge Statement, “MIT HackMed @ SG”, 7/2015 PATENT P. Ho, H.L. Leo, F. Cui, S.H. Ng, and F. Kabinejadian, "Membrane for covering a peripheral surface of a stent" (PCT) WO/2013/055293A1, 2013 (National phase filed in the US and Singapore). PUBLICATIONS Book and Book Chapters 1. F. Kabinejadian, D.N. Ghista, M. Kaabi Nezhadian, and H.L. Leo. “Hemodynamics of Coronary Artery Bypass Grafting: Conventional vs. Innovative Anastomotic Configuration Designs for Enhancing Patency” in “Coronary Graft Failure – State of the Art”, I.C. Tintoiu, M.J. Underwood, S.P. Cook, H. Kitabata, and A. Abbas (Editors), Springer International Publishing Switzerland, 2016 (invited chapter). 2. F. Kabinejadian, Y. Huo, D.N. Ghista, and G.S. Kassab. “Coronary Blood Flow Analysis and Coronary Bypass Graft Design” in “Cardiology Science and Engineering”, CRC Press, Taylor & Francis Group, 2016. 3. F. Kabinejadian, D.N. Ghista, and L.P. Chua. “Coupled Sequential Anastomotic Bypass Graft (CSABG) Design” in “Cardiology Science and Engineering”, CRC Press, Taylor & Francis Group, 2016. 4. D.N. Ghista and F. Kabinejadian. “Determination of Arterial Pulse Wave Propagation Velocity and Arterial Properties” in “Cardiology Science and Engineering”, CRC Press, Taylor & Francis Group, 2016. 5. D.N. Ghista, F. Kabinejadian, K. Subbaraj, and E. Fallen. “Left Ventricular Blood Pump Analysis of Intra-LV Flow Velocity and Pressure, for Coronary Bypass Surgery Candidacy” in “Cardiology Science and Engineering”, CRC Press, Taylor & Francis Group, 2016. 6. D.N. Ghista, L. Liu, and F. Kabinejadian. “Analysis for left ventricular pressure increase during isovolumic contraction phase due to activation of myocardial fibers” in “Cardiology Science and Engineering”, CRC Press, Taylor & Francis Group, 2016. 7. F. Kabinejadian and D.N. Ghista. “Coronary Artery Bypass Grafting Design Simulations: Emphasizing a Novel CABG Design of Sequential Anastomoses”, Lambert Academic Publishing, 2012. FOAD KABINEJADIAN Page 5 of 6 Refereed Journal Articles 1. F. Kabinejadian, M. Kaabi Nezhadian, F. Cui, P. Ho, and H.L. Leo. “Covered Stent Membrane Design for Treatment of Atherosclerotic Disease at Carotid Artery Bifurcation and Prevention of Thromboembolic Stroke: An In Vitro Experimental Study”, Artificial Organs 40(2), pp. 159-168, 2016. 2. F. Kabinejadian, B. Su, D.N. Ghista, M. Ismail, S. Kim, and H.L. Leo. “Sequential venous anastomosis design to enhance patency of arterio-venous grafts for hemodialysis”, Computer Methods in Biomechanics and Biomedical Engineering, 2016. 3. F. Kabinejadian, M. McElroy, A. Ruiz-Soler, H.L. Leo, M. Slevin, L. Badimon, and A. Keshmiri. “Numerical Assessment of Novel Helical/Spiral Grafts with Improved Hemodynamics for Distal Graft Anastomoses”, PLOS ONE, 2016 (in press). 4. G.P. Kumar, F. Kabinejadian, J. Liu, P. Ho, H.L. Leo, F. Cui. “Simulated Bench Testing to Evaluate the Mechanical Performance of New Carotid Stents”, Artificial Organs, 2016. 5. M. Ismail, G.P. Kumar, F. Kabinejadian, Y.N. Nguyen, F. Cui, E.L.W. Tay, and H.L. Leo. “An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing”, Cardiovascular Engineering and Technology 7(3), pp. 254-269, 2016. 6. F. Kabinejadian, F. Cui, B. Su, A. Danpinid, P. Ho, and H.L. Leo. “Effects of a Carotid Covered Stent with a Novel Membrane Design on the Blood Flow Regime and Hemodynamic Parameters Distribution at the Carotid Artery Bifurcation”, Medical & Biological Engineering & Computing 53(2), pp. 165-177, 2015. 7. Y.H. Kuan, F. Kabinejadian, V.T. Nguyen, B. Su, A.P. Yoganathan, and H.L. Leo. “Comparison of hinge microflow fields of bileaflet mechanical heart valves implanted in different sinus shape and downstream geometry”, Computer Methods in Biomechanics and Biomedical Engineering 18(16), pp. 1785-1796, 2015. 8. B. Su, L. Zhong, F. Kabinejadian, H.Q. Phang, G.P. Kumar, F. Cui, S. Kim, R.S. Tan, J.K.F. Hon, and H.L. Leo. “Numerical modeling of intraventricular flow during diastole after implantation of BMHV”, PLOS ONE 10(5): e0126315, 2015. 9. M. Ismail, F. Kabinejadian, and H.L. Leo, “In vitro investigation of the hemodynamics of transcatheter heterotopic valves implantation in the cavo-atrial junction”, Artificial Organs 39(9), pp. 803-814, 2015. 10. F. Kabinejadian, D.N. Ghista, B. Su, M. Kaabi Nezhadian, L.P. Chua, J.H. Yeo, H.L. Leo. “In Vitro Measurements of Velocity and Wall Shear Stress in a Novel Sequential Anastomotic Graft Design Model under Pulsatile Flow Conditions”, Medical Engineering & Physics 36(10), pp. 1233-1245, 2014. 11. Y.H. Kuan, V.T. Nguyen, F. Kabinejadian, B. Su, S. Kim, A.P. Yoganathan, and H.L. Leo. “Numerical analysis of the hemodynamic performance of bileaflet mechanical heart valves at different implantation angles”, Journal of Heart Valve Disease 23, pp. 642-650, 2014. 12. B. Su, Y. Huo, G.S. Kassab, F. Kabinejadian, S. Kim, H.L. Leo, and L. Zhong. “Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenoses”, Computers in Biology and Medicine 47, pp. 130-138, 2014. 13. F. Kabinejadian, F. Cui, Z. Zhang, P. Ho, and H.L. Leo. “A Novel Carotid Covered Stent Design: In Vitro Evaluation of Performance and Influence on the Blood Flow Regime at the Carotid Artery Bifurcation”, Annals of Biomedical Engineering 41(9), pp. 1990-2002, 2013. 14. D.N. Ghista and F. Kabinejadian*. “Coronary Artery Bypass Grafting Hemodynamics and Anastomosis Design: A Biomedical Engineering Review”, BioMedical Engineering OnLine, 12, 2013. 15. F. Kabinejadian* and D.N. Ghista. “Compliant Model of a Coupled Sequential Coronary Arterial Bypass Graft: Effects of Vessel Wall Elasticity and Non-Newtonian Rheology on Blood Flow Regime and Hemodynamic Parameters Distribution”, Medical Engineering & Physics 34, pp. 860-872, 2012. FOAD KABINEJADIAN Page 6 of 6 16. F. Kabinejadian, L.P. Chua, D.N. Ghista, M. Sankaranarayanan, and Y.S. Tan. “A Novel Coronary Artery Bypass Graft Design of Sequential Anastomoses”, Annals of Biomedical Engineering 38(10), pp. 3135-3150, 2010. 17. F. Kabinejadian, L.P. Chua, D.N. Ghista, and Y.S. Tan. “CABG Models Flow Simulation Study on the Effects of Valve Remnants in the Venous Graft”, Journal of Mechanics in Medicine and Biology 10, pp. 593-609, 2010. 18. A. Ruiz-Soler, F. Kabinejadian, and A. Keshmiri. “Optimization of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics”, under review. Select Oral Presentations / Conference Papers 1. F. Kabinejadian, M. Kaabi Nezhadian, F. Cui, P. Ho, and H.L. Leo. “Covered stent with perforated membrane for treatment of peripheral atheroembolic disease”, World Congress on Medical Physics & Biomedical Engineering, Toronto, June 7-12, 2015. 2. F. Kabinejadian, M. Kaabi Nezhadian, F. Cui, P. Ho, and H.L. Leo. “A novel covered stent design for treatment of peripheral atheroembolic disease”, International Conference on Experimental Mechanics (ICEM 2014), Singapore, November 2014. 3. F. Kabinejadian, F. Cui, H. Pei, H.L. Leo. “Evaluation of Hemodynamic Performance of a Novel Carotid Covered Stent”, The International Conference on Computational Methods (ICCM 2014), Cambridge, England, July 2014 (Invited Talk). 4. F. Kabinejadian, B. Su, H.L. Leo. “Intra-Ventricular Flow Dynamics Post-Implantation of a Bileaflet Mechanical Heart Valve”, The International Conference on Computational Methods (ICCM 2014), Cambridge, England, July 2014. 5. F. Kabinejadian, H.L. Leo. “In-Vitro Evaluation of Flow Modification by Covered Stents for Treatment th of Intracranial Aneurysms”, 15 International Conference on Biomedical Engineering, Singapore, December 4-7, 2013. 6. F. Kabinejadian, H.L. Leo, A. Danpinid, F. Cui, Z. Zhang, and P. Ho. “In Vitro Flow Measurements in th Anatomic Models of Carotid Artery Bifurcation, Using Particle Image Velocimetry (PIV) Technique”, 15 International Conference on Experimental Mechanics, Porto, July 22-27, 2012. 7. F. Kabinejadian, H.L. Leo, A. Danpinid, F. Cui, Z. Zhang, and P. Ho. “Particle Image Velocimetry (PIV) Flow Measurements of Carotid Artery Bifurcation with Application to a Novel Covered Carotid Stent Design”, World Congress on Medical Physics and Biomedical Engineering, Beijing, May 26-31, 2012. (IFMBE Proceedings Volume 39, 2013, pp. 1441-1444) 8. F. Kabinejadian, D.N. Ghista, and H.L. Leo. “Fluid-Structure Interaction Analysis of a Coupled th Sequential Coronary Arterial Bypass Graft”, 10 International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Berlin, April 11-14, 2012. 9. F. Kabinejadian, L.P. Chua, D.N. Ghista, and Y.S. Tan. “A New Coronary Artery Bypass Graft th (CABG) Distal Anastomosis Design”, 11 International Congress of the IUPESM - World Congress on Medical Physics and Biomedical Engineering, Munich, September 7-12, 2009. (IFMBE Proceedings, 2010, Volume 25/4, Pages 491-494) 10. F. Kabinejadian, L.P. Chua, D.N. Ghista, and Y.S. Tan. “Effect of Irregularities of Graft Inner Wall at th the Anastomosis of a Coronary Artery Bypass Graft”, 13 International Conference on Biomedical Engineering, Singapore, December 3-6, 2008. (IFMBE Proceedings, 2009, Volume 23, Track 5, Pages 1838-1841) 11. F. Kabinejadian, M. Alizadeh, and S. Ebrahimi. “A Blood Couette Flow Analysis, based on the Strainth Gradient Theory”, 13 Iranian Conference on Biomedical Engineering, Tehran, February 21-22, 2007.