Download Hyaluronic Acid in Ear, Nose and Throat (ENT) Hyaluronic acid and

Hyaluronic Acid in Ear, Nose and Throat (ENT)
Hyaluronic acid and the respiratory system
Hyaluronic acid is universally recognised as being the main molecular component of the
extracellular matrix. In the respiratory apparatus it is synthesized by rhinopharyngeal and
pulmonary interstitial fibroblasts, the tracheobronchial submucosal glands, and the goblet
cells of the lining epithelium, which add it to the mucus that covers and protects the
respiratory airways. As a result of this distribution, hyaluronic acid has a central role to play
in respiratory physiology, and is involved in many homeostatic mechanisms.
Hyaluronic acid administered via inhaler penetrates rapidly and becomes integrated in the
pulmonary interstice, preventing diffusion of macromolecules and regulating the migration
of the cell populations involved in phlogistic reactions. Its highly hydrophobic properties
also allows it to hydrate the entire respiratory tree, facilitating removal of catabolites and
allergens. As a result of its ability to form part of the glycoprotein component covering the
upper respiratory mucosa it is involved in regulating mucociliary clearance by disrupting
potential impairing allergenic or inflammatory factors, either from the environment or
endogenous.
THE IBSA TREATMENT PROPOSAL (YABRO®)
The IBSA range offers an innovative, effective and safe approach for phlogistic
pathologies in the ENT field, aimed at restoring and maintaining the physiological
conditions of the damaged interstice and pulmonary mucous membranes occurring in
chronic bronchial phlogosis, assisting with disorders of the upper respiratory airways and
improving restoration of the functions of the mucous membrane in the post-operative
phase of endonasal interventions, together with therapeutic treatments which have already
been prescribed.
This is a medical device containing a sterile, isotonic solution of 0.3% hyaluronic acid salt,
to be administered by nebulizer.