Download Neanderthals in Tibet

Neanderthals in Tibet
Neanderthals (with)in Tibetan people
The EPAS1 gene encodes a half of a transcription factor involved in the
induction of genes regulated by oxygen, which is induced as oxygen levels
fall (hypoxia).
From Wikipedia
Hypothesis?
Adaptation to high altitudes in Tibetans is explained by neanderthal/denisovan
introgression.
How would you demonstrate this hypothesis?
Filter Genotype data
Calculate Fst
Simulations, selection on a de-novo mutation and on standing variation
Search haplotypes in 1000 genomes database
Haplotype network.
D and S* statistics under models of no gene flow
Genome-wide FST versus maximal allele frequency difference
FST calculated for each SNP between Tibetan and Han populations.
Haplotype pattern in a region defined by SNPs that are at high frequency in Tibetans and
at low frequency in Han Chinese.
A haplotype network based on the number of pairwise differences between the 40
most common haplotypes.
Genealogical structure in a model with gene flow from Denisovans to Tibet