Download TEXT: Basic and Clinical Pharmacology by

UNIVERSITY OF BELIZE
Faculty of Nursing Health Sciences and Social Work
SEMESTER 2 2008-09
CODE:
PHAR 222 (PHARMACOLOGY II)
CREDITS:
4 CREDIT HOURS
DAY AND TIME:
INSTURCTOR:
Tuesday and Thursday 8:00am-9:40am
L. HARRIS-THURTON
OFFICE HOURS: Tuesday 2:00pm-3:00pm
PREREQUISITE: PHAR 221 (C or better)
COURSE DISCRIPTION: Studies the actions and effects of drugs on the
human body. Relevant pharmacokinetics is also examined. The course
concentrates on drugs affecting the Cardiovascular System, Blood,
Metabolic and Endocrine Systems, Central Nervous System and the
Respiratory System.
RATIONAL: To present current information on drugs that is important for
rational drug therapy.
COURSE OBJECTIVES: Students will be able to
1) Discuss drugs used in the prevention, treatment and maintenance
therapy of various diseases and medical conditions.
2) Discuss effects of different classes of drugs on various organ systems
of the human body
3) Discuss the mechanisms of actions, side effects, toxicity and
metabolism of the various drug classes
4) Determine and assess information necessary for rational drug therapy
for specific disease states and individual patients.
5) Describe appropriate roles of the pharmacist and other members of
the health care team.
COURSE OUTLINE:
DRUGS AFFECTING CARDIOVASCULAR SYSTEM
1. Antihypertensive drugs (Weeks 1-2)
a. Overview
b. Diuretics
c. Beta Adrenergic Blockers
d. Angiotensin Converting Enzyme Inhibitors
e. Angiotensin II Receptor Blockers
f. Calcium Channel Blockers
g. Alpha 1 Adrenergic Blockers
h. Alpha 2 Adrenergic Agonist
i. Vasodilators
2. Drugs used in the treatment of CHF (Week 3)
a. Overview
b. Inotropic Agents
c. Diuretics
d. Vasodilators
e. Beta Blockers
f. ACE Inhibitors
3. Antianginal drugs (Week 4)
a. Nitrates
b. Beta Blockers
c. Calcium Channel Blockers
4. Antiarrhythmic drugs (Week 4-5)
a. Na+ Channel Blockers (Class I)
b. Beta Adrenergic Blockers (Class II)
c. K+ Channel Blockers (Class III)
d. Ca++ Channel Blockers (ClassIV)
e. Other Antiarrhythmic Agents
TEST 1
DRUGS AFFECTING THE BLOOD
1. Antihyperlipidemic drugs (Week 6 )
2.
3. Anticoagulants and Coagulants (Week 7)
a. Platelet Inhibitors
b. Thrombolytic Agents
c. Treatment for Bleeding
4. Treatment of Anemia
a. Treatment of Sickle Cell Anemia
DRUGS AFFECTING THE METABOLIC AND ENDOCRINE SYSTEMS
1. Thyroid Disorders (Week 9)
a. Thyroid Hormones and Treatment of Hypothyroidism
b. Drugs used in the treatment of Hyperthyroidism
2. Drugs used in the treatment of Diabetes (week 9)
a. Insulin
b. Oral Hypogylcemics
o Sulfonylureas
o Biguanides
o Alpha Glucosidase Inhibitors
o Thiazolidinediones
TEST 2
DRUGS AFFECTING THE CENTRAL NERVOUS SYSTEM
1. Antidepressants (Week 10)
 Tri-cyclic Antidepressants
 Selective Serotonin Reuptake Inhibitors
 Monoamine Oxidaze Inhibitors
 Miscellaneous Agents
2. Anxiolytics and Sedative-Hypnotics (Week 10)
 Benzodiazepine
 Barbiturates
 Newer Agents
3. Antiparkinson Agents (Week 11)
 Levodopa
 Dopamine Receptor agonists
 Monoamine Oxidase Inhibitors
 Catechol-O-Methyltransferase Inhibitors
 Acetylcholine-Blocking Drugs
4. Drugs used in Seizure Disorders (Week 12)
 Phenytoin
 Carbamazepine
 Valproic acid
 Phenobarbital
 Ethosuximide
5. Antipsychotic Agents & Lithium (Week 13)
 Phenothiazine Derivatives
 Thioxanthene Derivatives
 Butyrophenone Derivatives
 Miscellaneous
7. General and Local Anesthetics (Week 14)
TEST 3
DRUGS AFFECTING RESPIRATORY SYSTEM (Week 15)
1. Drugs Used in Treatment of Asthma
2. Drugs used in the Treatment of COPD
3. Drugs Used in the Treatment of Upper Respiratory Symptoms
a. Rhinitis
b. Decongestants (topical and oral)
c. Expectorants
d. Antitussives
TEXT: Basic and Clinical Pharmacology by Bertram G. Katzung 10th
Edition
REFERENCES: Goodman and Gilman’s The Pharmacological Basis of
Therapeutics 9TH Ed.
Merck Manual, Eighteenth Edition (Merck Medicus, Internet Access)
Lippincott’s Illustrated Reviews: Pharmacology, 2nd Edition
Assessment Strategies
QUIZZES:
Quizzes will be given to ensure that students understand and can apply the
knowledge gained from class discussions, drug profiles and assignments. These
quizzes may from time to time include pharmaceutical calculations. Quizzes
may be in the written or oral form.
Quizzes may be unannounced.
3 Test (@15%each)
45%
Quizzes
15%
Final Exam
40
Test dates to be confirmed after discussion with class
Types of questions in tests and final exam will include: Multiple Choice, True
and False, Fill in the Blanks, Short answer, Essays.
CLASS POLICIES:
Students are expected to attend classes. University policy on attendance applies
(see Student Handbook).
Students are responsible for all notes, tests and assignments.
No make up quizzes will be allowed.
Unexcused absence from a test will mean an automatic zero.
Excuses due to illness should preferably be made before the test begins and no
later than the next meeting of class.
Five points will be deducted for each day a paper or assignment is late.
Passing grade for quizzes, tests and exams is 75%.
No school bags or books allowed in test or exam room.
Cell phones should be turned off during class time
No cell phones, iPods, MP3/MP4 players, Pocket PCs, or any such electronic
device, will allowed in test or exam rooms.
Anyone caught cheating will be asked to leave the exam room and the
University’s policy on cheating will be applied (see Student Handbook).
Lecturer reserves the right to assign seating for students during test and exams
No bags, books and papers allowed during test and exams.
Students must pass with a C+ or better to be able to continue to the
Pharmacology III course