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Stereotyped B-cell receptors in one-third of chronic
lymphocytic leukemia: a molecular classification with
implications for targeted therapies
by Andreas Agathangelidis, Nikos Darzentas, Anastasia Hadzidimitriou, Xavier
Brochet, Fiona Murray, Xiao-Jie Yan, Zadie Davis, Ellen J. van Gastel-Mol, Cristina
Tresoldi, Charles C. Chu, Nicola Cahill, Veronique Giudicelli, Boris Tichy, Lone Bredo
Pedersen, Letizia Foroni, Lisa Bonello, Agnieszka Janus, Karin Smedby, Achilles
Anagnostopoulos, Helene Merle-Beral, Nikolaos Laoutaris, Gunnar Juliusson, Paola
Francia di Celle, Sarka Pospisilova, Jesper Jurlander, Christian Geisler, Athanasios
Tsaftaris, Marie-Paule Lefranc, Anton W. Langerak, David Graham Oscier, Nicholas
Chiorazzi, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, and
Kostas Stamatopoulos
Blood
Volume 119(19):4467-4475
May 10, 2012
©2012 by American Society of Hematology
A limited number of major subsets accounts for a sizeable proportion of the CLL Ig repertoire.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology
Sequence logos of selected major subsets in CLL. (A) Subset 6 comprises 68 unmutated IGHV169/IGHD3-16/IGHJ3 rearrangements, characterized by pronounced overall similarity.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology
Two types of subset-defining VH CDR3 sequence patterns.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology
Stereotypes in CLL are disease-biased.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology
CLL Ig repertoire: one-third stereotyped, two-thirds heterogeneous.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology
Intriguing sequence similarities between different high-level subsets.
Andreas Agathangelidis et al. Blood 2012;119:4467-4475
©2012 by American Society of Hematology