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Honors Anatomy, Chapter 3
Cells and Tissues
Ohio State Virtual Histology
Part 2: Body Tissues
Intro
1. What are the four major tissue types?
Epithelial covers, protects, secretes and allows transport
Connective protects and transmits force
Muscular contracts
Nervous carries impulses
Epithelial Tissue
Intro
Special Characteristics of Epithelium
2. What are the special characteristics of epithelial tissue?
Highly cellular
Polarity: apical surface = top
Bottom bound to basement membrane
Avascular = no blood vessels
Regenerate easily
Classification of Epithelium
Intro
3. What two characteristics are used to classify epithelia?
Number of layers
Simple is 1 cell layer thick
Stratified is > 1 cell layer thick
Shape of the cells
Squamous are flat with flat nuclei
Cuboidal are boxy with round nuclei
Columnar are tall with stretched nuclei
4. How are the structures of simple and stratified epithelia suited for
their functions?
Simple are thin for absorption, secretion and filtration
Stratified are thick for protection
5. Exemplify and sketch each of the major types of epithelia.
Simple Epithelia
Simple Squamous
Line the air sacs in the lungs, kidney glomeruli, capillary walls
Simple Cuboidal
Kidney tubule, pancreatic ducts, sweat glands
Simple Columnar
Line the digestive tract interspersed with goblet cells
Pseudostratified Columnar
Nuclei are staggered; only looks stratified
Ciliated form lines the respiratory tract
Stratified Epithelia
Stratified Squamous
Cells get more squamous as the mature
Epidermis and the lining of the mouth
Stratified Cuboidal
Also in sweat glands, salivary gland ducts
Transitional
Stretchable: rounded cells when relaxed
Lines bladder and ureters
Glandular Epithelium
6. Compare and contrast endocrine and exocrine glands.
Both
Made up of >1 cells
Usually secrete an aqueous solution of proteins
Endocrine
Ductless; secrete directly into the blood
Ex.: thyroid, adrenals, pituitary
Exocrine
Secrete through a duct to the epithelium surface
Ex.: sweat, sebaceous, salivary, mammary
Connective tissue
Intro
Common Characteristics of Connective Tissue
7. List and describe common characteristics of connective tissue.
Variable blood supply
Cartilage and tendon have a poor supply
Bone has a good supply
Often with a large amount of extracellular matrix
Most of tendon is extracellular collagen fibers
Blood has soluble fibers stored in the plasma
Bone has mineralized protein between the cells
Adipose has little matrix
8. How is vascular supply related to the healing abilities of connective tissues?
Blood vessels deliver required materials
Contrast
Tendon: poor blood supply, heal poorly
Bone: rich blood supply, heal well
Types of Connective Tissue
9. Briefly describe the major types of connective tissue.
Bone
Mineralized protein matrix
Cells in spaces called lacunae
Cartilage
Protein matrix with reinforced various fibers
Hyaline is rubbery and smooth
Elastic is the most flexible
Fibrocartilage resists the most stress
Dense
Greatest amount of collagen fibers
Tendons, ligaments and dermis
Loose
Areolar
Watery layer right under epidermis
Adipose
Cells storing fat in large vacuoles
Reticular
Webbing reinforcing large organs like the lungs
Blood
Soluble fibrinogen makes fibers during blood clotting
Muscle Tissue
Intro
10. Contrast skeletal, cardiac, and smooth muscle.
Types of Muscle Tissue
Skeletal Muscle
In general, voluntary
Striated because of aligned myofibrils
Long and multinucleate
Pull on bones or skin
Cardiac Muscle
Involuntary
Uninucleate
Cells connected end-to-end by intercalated disks
Smooth Muscle
Involuntary
Uninucleate and spindle-shaped
Found in walls of blood vessels, bladder, digestive organs
Nervous Tissue
11. What types of cells make up nervous tissue?
Neurons conduct impulses
Supporting cells insulate, support, and protect
Tissue Repair
12. Contrast regeneration and fibrosis.
Regeneration
Replaces damaged tissue with the original type of cell
Ex.: epidermis
Fibrosis
Heals by laying down dense connective (scar) tissue
Ex.: dermis
13. Describe the phases of tissue repair.
Capillaries become permeable
Delivers clotting proteins, nutrients, white blood cells
Removes debris
Blood clot forms
Blocks blood loss
Holds edges of wound together
Isolates area so bacteria can’t spread
Granulation tissue forms
Bright pink because of budding capillaries
Reestablishes blood supply
Delivers repairing cells
Epithelium regenerates underneath the scab
Developmental Aspects of cells and Tissues
14. Explain the significance of the fact that some tissue types (muscle and nerve) are
largely amitotic after the growth stages are over.
Amitotic
= don’t divide after they mature
Cannot be replaced if damaged
Examples
Cardiac muscle cells
Neurons
Honors Anatomy, Chapter 4
Skin and Body Membranes
Intro
Classification of Body Membranes
Intro
15. Differentiate epithelial and connective tissue membranes.
Epithelial are an epithelial sheet over connective tissue
Connective tissue membranes have no epithelium
Epithelial Membranes
Intro
16. How do the different epithelial membranes function?
Cutaneous Membrane
= skin
Epidermis seals up the body from water loss and invasion
Dermis gives mechanical protection and nourishes the epidermis
Mucous Membranes
Lines body cavities open to the outside
All are moist and adapted for absorption or secretion
Serous Membranes
Line body cavities not open to outside
Simple squamous epithelium + loose connective tissue
Parietal covers the wall, visceral covers the organs
Provide fluid that lubricates organ movements
Connective Tissue Membranes
17. How do connective tissue membranes help the functioning of joints?
= synovial membranes associated with joints
Line and lubricate joint cavities, bursae, and tendon sheaths
Integumentary System (Skin)
Intro
Basic Skin Functions
18. List the important skin functions and the responsible skin components.
Protects from mechanical damage
Epidermis stratified squamous for scrapes
Dermis dense fibrous for penetration
Adipose in hypodermis cushions
Protects from chemical damage
Keratinized epidermis makes skin impermeable to water solutions
Protect from bacterial and viral damage
Epidermis keeps out bacteria and viruses
Acid mantle of sweat inhibits bacteria
Phagocytes in dermis attack bacteria that get through
Mast cells in dermis can trigger inflammation
Protect from UV
Absorbed by melanin produced by melanocytes
Protect from thermal damage
Heat and pain receptors
Protect from desiccation (drying out)
Stratified squamous seals water in
Temperature regulation
Sweat glands in dermis
Capillaries in dermis can open up or close up
Excretion of urea and uric acid
Sweat glands
Synthesizes vitamin D
Skin cells
Blood reservoir
Capillaries close up when more blood is required
Communication
Blushing
Structure of the Skin
Intro
19. Differentiate the basic structures of the epidermis, dermis and
subcutaneous tissue.
Epidermis
Stratified squamous
Nerve receptors
Melanocytes
Dermis
Areolar connective tissue
Dense fibrous connective tissue
Subcutaneous tissue (= hypodermis)
Adipose
Epidermis
20. Describe the layers of the epidermis.
Bottom = stratum basale
Where the cells divide
Has melanocytes, pigmented cells
Going up
Layers: spinosum, granulosum, lucidum
Become filled with keratin
Uppermost = corneum
Thickest
Dead cells
21. How do melanocytes produce and distribute pigment?
Sunlight stimulates melanocytes
Melanin granules made and moved to ends of processes
Phagocytized by keratinocytes
Arranged to shield the nucleus
Dermis
22. Differentiate the papillary and reticular layers of the dermis.
Projections of dermis poke up below undulating epidermis
= papillary layer
Aligned to make fingerprints
Also have sensory receptors
Below is the reticular layer
Collagen and elastic fibers provide toughness
Blood vessels and sensory receptors
23. How are the lines of tension in the skin used in surgery?
Lines of tension are the dominant direction of fibers
Cut parallel to minimize gaping and promote healing
Skin Color
24. What pigments contribute to skin color?
Brown melanin
Yellow-orange carotene
Pink oxygenated hemoglobin
25. What colors are described in medical settings?
Cyanosis = blue from lack of oxygen
Erythema = redness from blushing, fever, allergy
Pallor or blanching from stress, anemia, low blood pressure
Jaundice = yellowing from impaired liver function
Black and blue = hematoma from damage to vessels and release of
blood
Appendages of the Skin
Intro
Cutaneous Glands
26. Differentiate the functions of sebaceous and sweat glands.
Intro
Sebaceous Glands
Oil glands
Lubricates and protects hair and skin
Sweat Glands
Eccrine
Clear salty fluid with some metabolic wastes
Used for thermoregulation
Apocrine
Found in armpits
Produce sweat with fatty acids and proteins
Begin functioning at puberty
Hairs and Hair Follicles
27. Differentiate the hair shaft, root and bulb.
Shaft extends above the skin
Root is below the surface inside the follicle
Bulb at the bottom of the root
27. How do the shafts of curly hair differ from those of straight hair?
Curly: shaft is flat and ribbon-like
Straight: shaft is round
28. How do goose bumps form?
An arrector pili muscle is attached to each follicle
Various stimuli cause contraction, raise hair
Nails
29. What gives rise to finger and toenails?
Derived from epidermis
Nail bed is an extension of the stratum basale
Homeostatic Imbalances of Skin
Intro
Infections and Allergies
30. Describe common infections and allergies of skin.
Athlete’s foot: fungus causes redness and peeling
Boils: inflamed hair follicles and sebaceous glands
Cold sores
Herpes simplex infection
Small blisters triggered by fever, upset, UV
Contact dermatitis: allergy; itching, redness, blistering
Impetigo: staph infection; pink raised lesions
Psoriasis: immune reaction causes overgrowth; red, raised
Burns
31. Differentiate first-, second- and third-degree burns.
First
Redness, pain
Only affects epidermis
Second
With blistering
Affects epidermis and upper dermis
No scarring unless infected
Third
Epidermis and dermis gone or charred black
May be white from exposed dense fibrous tissue
Causes of death
Fluid loss  circulatory system collapse
Infection
Skin Cancer
Intro
32. What are the symptoms and significances of the various skin
cancers?
Basal Cell Carcinoma
Most common, least malignant
Shiny, dome-shaped nodules with beaded edges
Squamous cell Carcinoma
Scaly, reddened bumps
Can spread rapidly
Malignant Melanoma
Least common, most deadly
Caused by UV radiation
33. How is the ABCD rule applied to the recognition of melanoma?
A: asymmetrical
B: irregular borders
C: multicolored
D. diameter > 6 mm
Developmental Aspects of Skin and Body Membranes
34. How does sunlight affect skin?
Causes mutation  cancer
Breaks down elastic fibers  leathery, wrinkled, sagging skin
Bone Growth and Remodeling
35. Differentiate the development of long bones and flat bones.
Long bones
First formed as hyaline cartilage
Growth longer at epiphyseal plates between shaft and end
Plates are made of hyaline cartilage
Move outward as bone grows longer
New cartilage is added away from the center of the bone
Cartilage turns to bone toward the center
Flat bones are first formed as fibrous membranes
36. Order the four stages of bone healing.
Hematoma forms at break: clotted blood
Fibrocartilage callus
Bony callous: thick bone tissue
Remodeling
Bone tissue laid down where stresses are greatest
Removed where stresses are least