Download Syllabus: Advanced Topics in Biology: Population Genetics and

Biol 427
1
Syllabus: Human Diversity and Population Genetics v2
C. D. Jones.
Basic Structure: T/R 8:00AM-9:20 AM Class will include lecture and
reading/discussion. One midterm, two written assignments and one final. Potentially
homeworks and quizzes. Prerequisites: Biol 201 & 202
Lecture will introduce this subject and set up the questions that are discussed in the
paper(s) to be read. 1-3 papers or articles a week plus assignments from the textbook
(Human Evolutionary Genetics 2nd Edition).
Week1:
Week2:
Week3:
Week4:
Week5:
Week6:
Week7:
Introduction. Motivation and Questions
Coarse Overview and structure
Statistical approach to genetics
Genetic variation
Hardy-Weinberg
Assumptions
Populations and Genes
Modeling natural selection on genes
Roles of environment, evolution, and genetics
Fst -- one method of testing neutrality versus selection
Admixture and structure
Population Genetics
Neutral Theory
Quantitative genetics and humans
Heritability
Association Studies
Linkage
Association
GWAS
Trios vs Case Control
Prenatal screening
Designing GWAS
Sampling
Genotyping
Analysis
Replication
Biases
Midterm. (Start next section)
Makeup days :TBA
Students must have chosen the subjects for their presentations
NOTE: 9/24– Mid-term Exam
Genomes
Basic concepts
Population Genomics
Biol 427
Week8:
Week9:
Week10:
Week11:
Week 12
Week 13:
Week 14:
Week 15:
2
Evolutionary observations
Ancient genomes
Evolution and Humans
Genetics and Evolution
The Primates
The hominids
Admixture with Neanderthal
NOTE: 10/8-- Start-up idea due
Language & Pair Bonding
World Language and Genetic Patterns
Role of natural selection and language
FOXP2
Pair Bonding
Human population structure
Consanguinous matings
Patterns of Human Migration
Migration and language
Implications for GWAS
Evolution and Human Disease: genetic disease
Return to pedigrees for Simple traits
Sickle cell, CF
Adaptation in humans?
Diseases of Modernity
Intersection of genetics, evolution and environment
Type 2 diabetes
Heart disease
Obesity
Metagenomics
Microbiomes
The ecology of the gut
Bacteria and their role in health
Genomics of the microbiomes
External diseases and human evolution
CF, Sickle cell
HIV
NOTE: 11/19-- Grant Specific Aims due
Misc Topics
Agriculture and Biotechnology
Catch --up
Review & Perspective on directions of human study