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Stress resistance in fibroblasts from animals of long-lived species. Left panel: Resistance of cultured skin fibroblasts to hydrogen peroxide as a function of
species maximum lifespan in years. Species, from left to right, are hamster, rat, rabbit, sheep, pig, cow, and human. Reproduced with permission from
Kapahi P, Boulton ME, Kirkwood TB. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med. 1999;26(5–
6):495–500. Right panel: Resistance of cultured skin fibroblasts to cadmium as a function of species maximum lifespan in years. Species, left to right, are
laboratory mouse, wild-caught mouse, rat, red squirrel, white-footed mouse, deer mouse, fox squirrel, porcupine, beaver, and little brown bat. LD50 is the
amount of hydrogen peroxide or cadmium that kills 50% of the cells. Reproduced with permission from Harper JM, Salmon AB, Leiser SF, Galecki AT,
Source: Chapter 1. Biology of Aging and Longevity, Hazzard's Geriatric Medicine and Gerontology, 6e
Miller RA. Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone.
Citation: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S. Hazzard's Geriatric Medicine and Gerontology, 6e; 2009
Aging Cell. 2007;6:1–13.
Available at: http://mhmedical.com/ Accessed: April 30, 2017
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